| Publication type: | Book part |
| Type of review: | Editorial review |
| Title: | Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up |
| Authors: | Löffelholz, Christian Kaiser, Stephan C. Kraume, Matthias Eibl, Dieter Eibl-Schindler, Regine |
| DOI: | 10.1007/10_2013_187 |
| Published in: | Disposable bioreactors II |
| Editors of the parent work: | Eibl, Dieter Eibl-Schindler, Regine |
| Page(s): | 1 |
| Pages to: | 41 |
| Issue Date: | 2014 |
| Series: | Advances in Biochemical Engineering/Biotechnology |
| Series volume: | 138 |
| Publisher / Ed. Institution: | Springer |
| Publisher / Ed. Institution: | Berlin |
| ISBN: | 978-3-642-45157-7 978-3-642-45158-4 |
| Language: | English |
| Subjects: | Computational fluid dynamics; Engineering characteristics; Main applications; Scale-up; Single-use bioreactor types |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | During the past 10 years, single-use bioreactors have been well accepted in modern biopharmaceutical production processes targeting high-value products. Up to now, such processes have mainly been small- or medium-scale mammalian cell culture-based seed inoculum, vaccine or antibody productions. However, recently first attempts have been made to modify existing single-use bioreactors for the cultivation of plant cells and tissue cultures, and microorganisms. This has even led to the development of new single-use bioreactor types. Moreover, due to safety issues it has become clear that single-use bioreactors are the “must have” for expanding human stem cells delivering cell therapeutics, the biopharmaceuticals of the next generation. So it comes as no surprise that numerous different dynamic single-use bioreactor types, which are suitable for a wide range of applications, already dominate the market today. Bioreactor working principles, main applications, and bioengineering data are presented in this review, based on a current overview of greater than milliliter-scale, commercially available, dynamic single-use bioreactors. The focus is on stirred versions, which are omnipresent in R&D and manufacturing, and in particular Sartorius Stedim’s BIOSTAT family. Finally, we examine development trends for single-use bioreactors, after discussing proven approaches for fast scaling-up processes. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2263 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Löffelholz, C., Kaiser, S. C., Kraume, M., Eibl, D., & Eibl-Schindler, R. (2014). Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up. In D. Eibl & R. Eibl-Schindler (Eds.), Disposable bioreactors II (pp. 1–41). Springer. https://doi.org/10.1007/10_2013_187
Löffelholz, C. et al. (2014) ‘Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up’, in D. Eibl and R. Eibl-Schindler (eds) Disposable bioreactors II. Berlin: Springer, pp. 1–41. Available at: https://doi.org/10.1007/10_2013_187.
C. Löffelholz, S. C. Kaiser, M. Kraume, D. Eibl, and R. Eibl-Schindler, “Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up,” in Disposable bioreactors II, D. Eibl and R. Eibl-Schindler, Eds. Berlin: Springer, 2014, pp. 1–41. doi: 10.1007/10_2013_187.
LÖFFELHOLZ, Christian, Stephan C. KAISER, Matthias KRAUME, Dieter EIBL und Regine EIBL-SCHINDLER, 2014. Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up. In: Dieter EIBL und Regine EIBL-SCHINDLER (Hrsg.), Disposable bioreactors II. Berlin: Springer. S. 1–41. ISBN 978-3-642-45157-7
Löffelholz, Christian, Stephan C. Kaiser, Matthias Kraume, Dieter Eibl, and Regine Eibl-Schindler. 2014. “Dynamic Single-Use Bioreactors Used in Modern Liter- and M3-Scale Biotechnological Processes : Engineering Characteristics and Scaling Up.” In Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, 1–41. Berlin: Springer. https://doi.org/10.1007/10_2013_187.
Löffelholz, Christian, et al. “Dynamic Single-Use Bioreactors Used in Modern Liter- and M3-Scale Biotechnological Processes : Engineering Characteristics and Scaling Up.” Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, Springer, 2014, pp. 1–41, https://doi.org/10.1007/10_2013_187.
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