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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Differential alterations in resting state functional connectivity associated with depressive symptoms and early life adversity
Authors: Fadel, Eleonora
Boeker, Heinz
Gaertner, Matti
Richter, Andre
Kleim, Birgit
Seifritz, Erich
Grimm, Simone
Wade-Bohleber, Laura Maria
et. al: No
DOI: 10.3390/brainsci11050591
Published in: Brain Sciences
Volume(Issue): 11
Issue: 5
Page(s): 591
Issue Date: May-2021
Publisher / Ed. Institution: MDPI
ISSN: 2076-3425
Language: English
Subjects: Depression; Early life adversity; Functional connectivity; Resting state fMRI
Subject (DDC): 616.8: Neurology, diseases of nervous system
Abstract: Depression and early life adversity (ELA) are associated with aberrant resting state functional connectivity (FC) of the default mode (DMN), salience (SN), and central executive networks (CEN). However, the specific and differential associations of depression and ELA with FC of these networks remain unclear. Applying a dimensional approach, here we analyzed associations of FC between major nodes of the DMN, SN, and CEN with severity of depressive symptoms and ELA defined as childhood abuse and neglect in a sample of 83 healthy and depressed subjects. Depressive symptoms were linked to increased FC within the SN and decreased FC of the SN with the DMN and CEN. Childhood abuse was associated with increased FC within the SN, whereas childhood neglect was associated with decreased FC within the SN and increased FC between the SN and the DMN. Our study thus provides evidence for differential associations of depressive symptoms and ELA with resting state FC and contributes to a clarification of previously contradictory findings. Specific FC abnormalities may underlie specific cognitive and emotional impairments. Future research should link specific clinical symptoms resulting from ELA to FC patterns thereby characterizing depression subtypes with specific neurobiological signatures.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Applied Psychology
Organisational Unit: Psychological Institute (PI)
Appears in collections:Publikationen Angewandte Psychologie

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