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dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorEibl, Dieter-
dc.date.accessioned2018-01-30T13:02:34Z-
dc.date.available2018-01-30T13:02:34Z-
dc.date.issued2009-
dc.identifier.isbn978-3-540-69356-7de_CH
dc.identifier.isbn978-3-540-69357-4de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2269-
dc.description.abstractIn order to increase process efficiency, many pharmaceutical and biotechnology companies have introduced disposable bag technology over the last 10 years. Because this technology also greatly reduces the risk of cross-contamination, disposable bags are preferred in applications in which an absolute or improved process safety is a necessity, namely the production of functional tissue for implantation (tissue engineering), the production of human cells for the treatment of cancer and immune system diseases (cellular therapy), the production of viruses for gene therapies, the production of therapeutic proteins, and veterinary as well as human vaccines. Bioreactors with a pre-sterile cultivation bag made of plastic material are currently used in both development and manufacturing processes primarily operating with animal and human cells at small- and middle-volume scale. Because of their scalability, hydrodynamic expertise and the convincing results of oxygen transport efficiency studies, wave-mixed bioreactors are the most used, together with stirred bag bioreactors and static bags, which have the longest tradition. Starting with a general overview of disposable bag bioreactors and their main applications, this chapter summarizes the working principles and engineering aspects of bag bioreactors suitable for cell expansion, formation of functional tissue and production of therapeutic agents. Furthermore, results from selected cultivation studies are presented and discussed.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofBioreactor systems for tissue engineeringde_CH
dc.relation.ispartofseriesAdvances in Biochemical Engineering/Biotechnologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectKeywords Cell expansionde_CH
dc.subjectDisposable bag bioreactorde_CH
dc.subjectFunctional tissuede_CH
dc.subjectStem cellsde_CH
dc.subjectTherapeutic agentsde_CH
dc.subject.ddc610: Medizin und Gesundheitde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleApplication of disposable bag-bioreactors in tissue engineering and for production of therapeutic agentsde_CH
dc.typeBuchbeitragde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeBerlinde_CH
dc.identifier.doi10.1007/10_2008_23de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end207de_CH
zhaw.pages.start183de_CH
zhaw.parentwork.editorKasper, Cornelia-
zhaw.parentwork.editorvan Griensven, Martijn-
zhaw.parentwork.editorPörtner, Ralf-
zhaw.publication.statuspublishedVersionde_CH
zhaw.series.number112de_CH
zhaw.publication.reviewEditorial reviewde_CH
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Eibl-Schindler, R., & Eibl, D. (2009). Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents. In C. Kasper, M. van Griensven, & R. Pörtner (Eds.), Bioreactor systems for tissue engineering (pp. 183–207). Springer. https://doi.org/10.1007/10_2008_23
Eibl-Schindler, R. and Eibl, D. (2009) ‘Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents’, in C. Kasper, M. van Griensven, and R. Pörtner (eds) Bioreactor systems for tissue engineering. Berlin: Springer, pp. 183–207. Available at: https://doi.org/10.1007/10_2008_23.
R. Eibl-Schindler and D. Eibl, “Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents,” in Bioreactor systems for tissue engineering, C. Kasper, M. van Griensven, and R. Pörtner, Eds. Berlin: Springer, 2009, pp. 183–207. doi: 10.1007/10_2008_23.
EIBL-SCHINDLER, Regine und Dieter EIBL, 2009. Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents. In: Cornelia KASPER, Martijn VAN GRIENSVEN und Ralf PÖRTNER (Hrsg.), Bioreactor systems for tissue engineering. Berlin: Springer. S. 183–207. ISBN 978-3-540-69356-7
Eibl-Schindler, Regine, and Dieter Eibl. 2009. “Application of Disposable Bag-Bioreactors in Tissue Engineering and for Production of Therapeutic Agents.” In Bioreactor Systems for Tissue Engineering, edited by Cornelia Kasper, Martijn van Griensven, and Ralf Pörtner, 183–207. Berlin: Springer. https://doi.org/10.1007/10_2008_23.
Eibl-Schindler, Regine, and Dieter Eibl. “Application of Disposable Bag-Bioreactors in Tissue Engineering and for Production of Therapeutic Agents.” Bioreactor Systems for Tissue Engineering, edited by Cornelia Kasper et al., Springer, 2009, pp. 183–207, https://doi.org/10.1007/10_2008_23.


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