Influence of interfacial force models and population balance models on the kLa value in stirred bioreactors

Seidel, Stefan; Eibl, Dieter

doi:10.3390/pr9071185

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-22798

Full metadata record

DC Field	Value	Language
dc.contributor.author	Seidel, Stefan	-
dc.contributor.author	Eibl, Dieter	-
dc.date.accessioned	2021-07-09T07:33:54Z	-
dc.date.available	2021-07-09T07:33:54Z	-
dc.date.issued	2021-07-07	-
dc.identifier.issn	2227-9717	de_CH
dc.identifier.uri	https://digitalcollection.zhaw.ch/handle/11475/22798	-
dc.description.abstract	Optimal oxygen supply is vitally important for the cultivation of aerobically growing cells, as it has a direct influence on cell growth and product formation. A process engineering parameter directly related to oxygen supply is the volumetric oxygen mass transfer coefficient kLa. It is the influences on kLa and computing time of different interfacial force and population balance models in stirred bioreactors that have been evaluated in this study. For this investigation, the OpenFOAM 7 open-source toolbox was utilized. Firstly, the Euler–Euler model with a constant bubble diameter was applied to a 2L scale bioreactor to statistically examine the influence of different interfacial models on the kLa value. It was shown that the kL model and the constant bubble diameter have the greatest influence on the calculated kLa value. To eliminate the problem of a constant bubble diameter and to take effects such as bubble breakup and coalescence into account, the Euler–Euler model was coupled with population balance models (PBM). For this purpose, four coalescence and five bubble breakup models were examined. Ultimately, it was established that, for all of the models tested, coupling computational fluid dynamics (CFD) with PBM resulted in better agreement with the experimental data than using the Euler–Euler model. However, it should be noted that the higher accuracy of the PBM coupled models requires twice the computation time.	de_CH
dc.language.iso	en	de_CH
dc.publisher	MDPI	de_CH
dc.relation.ispartof	Processes	de_CH
dc.rights	http://creativecommons.org/licenses/by/4.0/	de_CH
dc.subject	Bioreactor characterization	de_CH
dc.subject	CFD simulation	de_CH
dc.subject	Drag force	de_CH
dc.subject	Interfacial force	de_CH
dc.subject	kLa value	de_CH
dc.subject	Multiphase modeling	de_CH
dc.subject	Oxygen transfer rate	de_CH
dc.subject	Population balance model	de_CH
dc.subject.ddc	660: Technische Chemie	de_CH
dc.title	Influence of interfacial force models and population balance models on the kLa value in stirred bioreactors	de_CH
dc.type	Beitrag in wissenschaftlicher Zeitschrift	de_CH
dcterms.type	Text	de_CH
zhaw.departement	Life Sciences und Facility Management	de_CH
zhaw.organisationalunit	Institut für Chemie und Biotechnologie (ICBT)	de_CH
dc.identifier.doi	10.3390/pr9071185	de_CH
dc.identifier.doi	10.21256/zhaw-22798	-
zhaw.funding.eu	No	de_CH
zhaw.issue	7	de_CH
zhaw.originated.zhaw	Yes	de_CH
zhaw.pages.start	1185	de_CH
zhaw.publication.status	publishedVersion	de_CH
zhaw.volume	9	de_CH
zhaw.publication.review	Peer review (Publikation)	de_CH
zhaw.webfeed	Verfahrenstechnik	de_CH
zhaw.author.additional	No	de_CH
zhaw.display.portrait	Yes	de_CH
zhaw.monitoring.costperiod	2021	de_CH
Appears in collections:	Publikationen Life Sciences und Facility Management

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Seidel, S., & Eibl, D. (2021). Influence of interfacial force models and population balance models on the kLa value in stirred bioreactors. Processes, 9(7), 1185. https://doi.org/10.3390/pr9071185

Seidel, S. and Eibl, D. (2021) ‘Influence of interfacial force models and population balance models on the kLa value in stirred bioreactors’, Processes, 9(7), p. 1185. Available at: https://doi.org/10.3390/pr9071185.

S. Seidel and D. Eibl, “Influence of interfacial force models and population balance models on the kLa value in stirred bioreactors,” Processes, vol. 9, no. 7, p. 1185, Jul. 2021, doi: 10.3390/pr9071185.

SEIDEL, Stefan und Dieter EIBL, 2021. Influence of interfacial force models and population balance models on the kLa value in stirred bioreactors. Processes. 7 Juli 2021. Bd. 9, Nr. 7, S. 1185. DOI 10.3390/pr9071185

Seidel, Stefan, and Dieter Eibl. 2021. “Influence of Interfacial Force Models and Population Balance Models on the kLa Value in Stirred Bioreactors.” Processes 9 (7): 1185. https://doi.org/10.3390/pr9071185.

Seidel, Stefan, and Dieter Eibl. “Influence of Interfacial Force Models and Population Balance Models on the kLa Value in Stirred Bioreactors.” Processes, vol. 9, no. 7, July 2021, p. 1185, https://doi.org/10.3390/pr9071185.