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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Anticipating control over aversive stimuli is mediated by the medial prefrontal cortex : an fMRI study with healthy adults
Authors: Wade-Bohleber, Laura Maria
Haugg, Amelie
Huber, Sabrina
Ernst, Jutta
Grimm, Simone
Recher, Dominique
Richter, Andre
Seifritz, Erich
Boeker, Heinz
Northoff, Georg
et. al: No
DOI: 10.1002/hbm.25549
Published in: Human Brain Mapping
Volume(Issue): 42
Issue: 13
Page(s): 4327
Pages to: 4335
Issue Date: 2021
Publisher / Ed. Institution: Wiley
ISSN: 1065-9471
Language: English
Subjects: Aversion; Control anticipation; Functional magnetic resonance imaging; Medial prefrontal cortex
Subject (DDC): 616.8: Neurology, diseases of nervous system
Abstract: The anticipation of control over aversive events in life is relevant for our mental health. Insights on the underlying neural mechanisms remain limited. We developed a new functional magnetic resonance imaging (fMRI) task that uses auditory stimuli to explore the neural correlates of (1) the anticipation of control over aversion and (2) the processing of aversion. In a sample of 25 healthy adults, we observed increased neural activation in the medial prefrontal cortex (ventromedial prefrontal cortex and rostral anterior cingulate cortex), other brain areas relevant for reward anticipation (ventral striatum, brainstem [ventral tegmental area], midcingulate cortex), and the posterior cingulate cortex when they anticipated control over aversion compared with anticipating no control (1). The processing of aversive sounds compared to neutral sounds (2) was associated with increased neural activation in the bilateral posterior insula. Our findings provide evidence for the important role of medial prefrontal regions in control anticipation and highlight the relevance of conceiving the neural mechanisms involved within a reward-based framework.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Applied Psychology
Organisational Unit: Psychological Institute (PI)
Appears in collections:Publikationen Angewandte Psychologie

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