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dc.contributor.authorNatsch, Andreas-
dc.contributor.authorKern, Susanne-
dc.contributor.authorCorbi, Elise-
dc.contributor.authorPérès, Christophe-
dc.contributor.authorNägelin, Marco-
dc.contributor.authorLeijs, Hans-
dc.contributor.authorvon Strien, Michel-
dc.contributor.authorCalandra, Michael J.-
dc.contributor.authorWang, Ying-
dc.date.accessioned2022-01-14T13:27:28Z-
dc.date.available2022-01-14T13:27:28Z-
dc.date.issued2018-04-22-
dc.identifier.issn0882-5734de_CH
dc.identifier.issn1099-1026de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/23921-
dc.description.abstractThe fragrant terpenes limonene and linalool can form skin-sensitizing hydroperoxides (HPs) upon prolonged exposure to air. Sources of exposure of consumers to sensitizing doses of HPs have not been identified, and it is not clear whether fragranced products are a relevant source. Previously this question was addressed via analytical studies on fine fragrances; however, linalool and limonene are widely used in different consumer products, especially in other leave-on toiletries. Hence, analytical methods also need to be able to detect potential HPs in more complex consumer product matrices. Here we applied different simple extraction methods and a toolbox of analytical methods to creams and lotions. Blinded samples of a commercial skin cream and a body lotion were spiked with four different HPs at different doses. Five laboratories analysed the samples with a method based on HP reduction in the sample, followed by Extrelut® NT extraction and GC-MS to quantify the formed alcohols. This method found an average recovery of spiked levels of 80–105%, with a relative standard deviation between laboratories of 11–25% in samples spiked with 100–200 μg g−1. Quantification was also possible in samples spiked with 20–50 μg mL−1, with a relative standard deviation between laboratories of 11–38%. Thus, this method can indirectly detect low levels of HPs in complex bases. In parallel, the same samples were analysed with three LC-based methods directly detecting the parent HPs: LC coupled with chemiluminescence, LC-Q-TOF-MS, and LC-orbitrap-MS. On average, the different analytes were detected with a recovery of 80–143%. No HPs were detected in the non-spiked products, despite the fact that they do contain linalool and limonene. Results of these studies indicate that consumer exposure can now be studied routinely in different product types as the required methods are ready for roll-out.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofFlavour and Fragrance Journalde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectCreamde_CH
dc.subjectGC-MSde_CH
dc.subjectLC-MSde_CH
dc.subjectLotionde_CH
dc.subjectQuantificationde_CH
dc.subjectSkin allergyde_CH
dc.subjectTerpene hydroperoxidesde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleInterlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic basesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/ffj.3451de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end330de_CH
zhaw.pages.start322de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume33de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Natsch, A., Kern, S., Corbi, E., Pérès, C., Nägelin, M., Leijs, H., von Strien, M., Calandra, M. J., & Wang, Y. (2018). Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases. Flavour and Fragrance Journal, 33(4), 322–330. https://doi.org/10.1002/ffj.3451
Natsch, A. et al. (2018) ‘Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases’, Flavour and Fragrance Journal, 33(4), pp. 322–330. Available at: https://doi.org/10.1002/ffj.3451.
A. Natsch et al., “Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases,” Flavour and Fragrance Journal, vol. 33, no. 4, pp. 322–330, Apr. 2018, doi: 10.1002/ffj.3451.
NATSCH, Andreas, Susanne KERN, Elise CORBI, Christophe PÉRÈS, Marco NÄGELIN, Hans LEIJS, Michel VON STRIEN, Michael J. CALANDRA und Ying WANG, 2018. Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases. Flavour and Fragrance Journal. 22 April 2018. Bd. 33, Nr. 4, S. 322–330. DOI 10.1002/ffj.3451
Natsch, Andreas, Susanne Kern, Elise Corbi, Christophe Pérès, Marco Nägelin, Hans Leijs, Michel von Strien, Michael J. Calandra, and Ying Wang. 2018. “Interlaboratory Evaluation of Methods to Quantify Skin-Sensitizing Hydroperoxides of Limonene and Linalool (II) : Analysis in Cosmetic Bases.” Flavour and Fragrance Journal 33 (4): 322–30. https://doi.org/10.1002/ffj.3451.
Natsch, Andreas, et al. “Interlaboratory Evaluation of Methods to Quantify Skin-Sensitizing Hydroperoxides of Limonene and Linalool (II) : Analysis in Cosmetic Bases.” Flavour and Fragrance Journal, vol. 33, no. 4, Apr. 2018, pp. 322–30, https://doi.org/10.1002/ffj.3451.


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