Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-24909Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Cadosch, Dominique | - |
| dc.contributor.author | Garcia, Victor | - |
| dc.contributor.author | Jensen, Jørgen S. | - |
| dc.contributor.author | Low, Nicola | - |
| dc.contributor.author | Althaus, Christian L. | - |
| dc.date.accessioned | 2022-04-29T15:31:58Z | - |
| dc.date.available | 2022-04-29T15:31:58Z | - |
| dc.date.issued | 2020-06-16 | - |
| dc.identifier.issn | 2167-8359 | de_CH |
| dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/24909 | - |
| dc.description.abstract | Background: The rapid spread of azithromycin resistance in sexually transmitted Mycoplasma genitalium infections is a growing concern. It is not yet clear to what degree macrolide resistance in M. genitalium results from the emergence of de novo mutations or the transmission of resistant strains. Methods: We developed a compartmental transmission model to investigate the contribution of de novo macrolide resistance mutations to the spread of antimicrobial-resistant M. genitalium. We fitted the model to resistance data from France, Denmark and Sweden, estimated the time point of azithromycin introduction and the rates at which infected individuals receive treatment, and projected the future spread of resistance. Results: The high probability of de novo resistance in M. genitalium accelerates the early spread of antimicrobial resistance. The relative contribution of de novo resistance subsequently decreases, and the spread of resistant infections in France, Denmark and Sweden is now mainly driven by transmitted resistance. If treatment with single-dose azithromycin continues at current rates, macrolide-resistant M. genitalium infections will reach 25% (95% confidence interval, CI [9–30]%) in France, 84% (95% CI [36–98]%) in Denmark and 62% (95% CI [48–76]%) in Sweden by 2025. Conclusions: Blind treatment of urethritis with single-dose azithromycin continues to select for the spread of macrolide resistant M. genitalium. Clinical management strategies for M. genitalium should limit the unnecessary use of macrolides. | de_CH |
| dc.language.iso | en | de_CH |
| dc.publisher | PeerJ | de_CH |
| dc.relation.ispartof | PeerJ | de_CH |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | de_CH |
| dc.subject | Antibiotic resistance | de_CH |
| dc.subject | Mathematical model | de_CH |
| dc.subject | Mycoplasma genitalium | de_CH |
| dc.subject | Sexually transmitted infection | de_CH |
| dc.subject.ddc | 616: Innere Medizin und Krankheiten | de_CH |
| dc.title | Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium | de_CH |
| dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
| dcterms.type | Text | de_CH |
| zhaw.departement | Life Sciences und Facility Management | de_CH |
| zhaw.organisationalunit | Institut für Computational Life Sciences (ICLS) | de_CH |
| dc.identifier.doi | 10.7717/peerj.8913 | de_CH |
| dc.identifier.doi | 10.21256/zhaw-24909 | - |
| dc.identifier.pmid | 32292658 | de_CH |
| zhaw.funding.eu | No | de_CH |
| zhaw.originated.zhaw | Yes | de_CH |
| zhaw.pages.start | e8913 | de_CH |
| zhaw.publication.status | publishedVersion | de_CH |
| zhaw.volume | 8 | de_CH |
| zhaw.publication.review | Peer review (Publikation) | de_CH |
| zhaw.webfeed | Applied Mathematical Biology | de_CH |
| zhaw.funding.zhaw | Exploring the silent fitness landscape | de_CH |
| zhaw.author.additional | No | de_CH |
| zhaw.display.portrait | Yes | de_CH |
| Appears in collections: | Publikationen Life Sciences und Facility Management | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2020_Cadosch_Understanding_the_spread_of_de_novo_PeerJ.pdf | 347.29 kB | Adobe PDF |  View/Open |
Show simple item record
Cadosch, D., Garcia, V., Jensen, J. S., Low, N., & Althaus, C. L. (2020). Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium. PeerJ, 8, e8913. https://doi.org/10.7717/peerj.8913
Cadosch, D. et al. (2020) ‘Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium’, PeerJ, 8, p. e8913. Available at: https://doi.org/10.7717/peerj.8913.
D. Cadosch, V. Garcia, J. S. Jensen, N. Low, and C. L. Althaus, “Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium,” PeerJ, vol. 8, p. e8913, Jun. 2020, doi: 10.7717/peerj.8913.
CADOSCH, Dominique, Victor GARCIA, Jørgen S. JENSEN, Nicola LOW und Christian L. ALTHAUS, 2020. Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium. PeerJ. 16 Juni 2020. Bd. 8, S. e8913. DOI 10.7717/peerj.8913
Cadosch, Dominique, Victor Garcia, Jørgen S. Jensen, Nicola Low, and Christian L. Althaus. 2020. “Understanding the Spread of de Novo and Transmitted Macrolide-Resistance in Mycoplasma Genitalium.” PeerJ 8 (June): e8913. https://doi.org/10.7717/peerj.8913.
Cadosch, Dominique, et al. “Understanding the Spread of de Novo and Transmitted Macrolide-Resistance in Mycoplasma Genitalium.” PeerJ, vol. 8, June 2020, p. e8913, https://doi.org/10.7717/peerj.8913.
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