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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26098
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dc.contributor.authorLing, Ling-
dc.contributor.authorRen, Xiafei-
dc.contributor.authorCao, Xue-
dc.contributor.authorHassan, Afizah Binte Mohd-
dc.contributor.authorMah, Sophia-
dc.contributor.authorSathiyanathan, Padmapriya-
dc.contributor.authorSmith, Raymond A. A.-
dc.contributor.authorTan, Clarissa L. L.-
dc.contributor.authorEio, Michelle-
dc.contributor.authorSamsonraj, Rebekah M.-
dc.contributor.authorvan Wijnen, Andre J.-
dc.contributor.authorRaghunath, Michael-
dc.contributor.authorNurcombe, Victor-
dc.contributor.authorHui, James H.-
dc.contributor.authorCool, Simon M.-
dc.date.accessioned2022-11-17T11:44:13Z-
dc.date.available2022-11-17T11:44:13Z-
dc.date.issued2020-
dc.identifier.issn2213-6711de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26098-
dc.description.abstractHuman mesenchymal stem cell (hMSC) therapy offers significant potential for osteochondral regeneration. Such applications require their ex vivo expansion in media frequently supplemented with fibroblast growth factor 2 (FGF2). Particular heparan sulfate (HS) fractions stabilize FGF2-FGF receptor complexes. We show that an FGF2-binding HS variant (HS8) accelerates the expansion of freshly isolated bone marrow hMSCs without compromising their naivety. Importantly, the repair of osteochondral defects in both rats and pigs is improved after treatment with HS8-supplemented hMSCs (MSCHS8), when assessed histologically, biomechanically, or by MRI. Thus, supplementing hMSC culture media with an HS variant that targets endogenously produced FGF2 allows the elimination of exogenous growth factors that may adversely affect their therapeutic potency.de_CH
dc.language.isoende_CH
dc.publisherCell Pressde_CH
dc.relation.ispartofStem Cell Reportsde_CH
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/de_CH
dc.subjectHeparan sulfatede_CH
dc.subjectStemnessde_CH
dc.subjectEx vivo expansionde_CH
dc.subjectFGF2de_CH
dc.subjectOsteochondral regenerationde_CH
dc.subjectCartilage repairde_CH
dc.subjectEfficacyde_CH
dc.subjectPotencyde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleEnhancing the efficacy of stem cell therapy with glycosaminoglycansde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.stemcr.2019.12.003de_CH
dc.identifier.doi10.21256/zhaw-26098-
dc.identifier.pmid31902704de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end121de_CH
zhaw.pages.start105de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume14de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Ling, L., Ren, X., Cao, X., Hassan, A. B. M., Mah, S., Sathiyanathan, P., Smith, R. A. A., Tan, C. L. L., Eio, M., Samsonraj, R. M., van Wijnen, A. J., Raghunath, M., Nurcombe, V., Hui, J. H., & Cool, S. M. (2020). Enhancing the efficacy of stem cell therapy with glycosaminoglycans. Stem Cell Reports, 14(1), 105–121. https://doi.org/10.1016/j.stemcr.2019.12.003
Ling, L. et al. (2020) ‘Enhancing the efficacy of stem cell therapy with glycosaminoglycans’, Stem Cell Reports, 14(1), pp. 105–121. Available at: https://doi.org/10.1016/j.stemcr.2019.12.003.
L. Ling et al., “Enhancing the efficacy of stem cell therapy with glycosaminoglycans,” Stem Cell Reports, vol. 14, no. 1, pp. 105–121, 2020, doi: 10.1016/j.stemcr.2019.12.003.
LING, Ling, Xiafei REN, Xue CAO, Afizah Binte Mohd HASSAN, Sophia MAH, Padmapriya SATHIYANATHAN, Raymond A. A. SMITH, Clarissa L. L. TAN, Michelle EIO, Rebekah M. SAMSONRAJ, Andre J. VAN WIJNEN, Michael RAGHUNATH, Victor NURCOMBE, James H. HUI und Simon M. COOL, 2020. Enhancing the efficacy of stem cell therapy with glycosaminoglycans. Stem Cell Reports. 2020. Bd. 14, Nr. 1, S. 105–121. DOI 10.1016/j.stemcr.2019.12.003
Ling, Ling, Xiafei Ren, Xue Cao, Afizah Binte Mohd Hassan, Sophia Mah, Padmapriya Sathiyanathan, Raymond A. A. Smith, et al. 2020. “Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans.” Stem Cell Reports 14 (1): 105–21. https://doi.org/10.1016/j.stemcr.2019.12.003.
Ling, Ling, et al. “Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans.” Stem Cell Reports, vol. 14, no. 1, 2020, pp. 105–21, https://doi.org/10.1016/j.stemcr.2019.12.003.


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