| Publication type: | Conference poster |
| Type of review: | Not specified |
| Title: | Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor |
| Authors: | Rossi, Lia Schirmer, Cedric Teale, Misha Kurt, Fabienne Rosenthal, Florian Eibl, Dieter |
| et. al: | No |
| Conference details: | BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019 |
| Issue Date: | Jul-2019 |
| Publisher / Ed. Institution: | ZHAW Zürcher Hochschule für Angewandte Wissenschaften |
| Language: | English |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | Single-use systems have become an essential part of research and the production of biopharmaceuticals. The use of single-use systems (also called "disposables") offers a high level of biosafety and process reliability. Currently, one of the most common disposable bioreactors is a wave-mixed system. They are mainly used in cell culture technology for the cultivation of mammalian cells. The oxygen mass transfer coefficient is a limiting factor in wave-bag cultivation systems due to surface aeration. We therefore propose wave-mixed systems as a potential tool for the cultivation of strictly anaerobic microorganisms. In cooperation with PharmaBiome AG, a feasibility study for the cultivation of strictly anaerobic intestinal bacteria was carried out. The recording of the redox potential is essential for the process control of anaerobic cultivation. In addition, anaerobic inoculation methods have to be feasible, even outside the anaerobic workbench. Therefore, the modification of the wave-bag included the installation of a redox probe and an anaerobic inoculation method. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/26136 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Not specified |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Published as part of the ZHAW project: | Microbiome therapeutics |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Rossi, L., Schirmer, C., Teale, M., Kurt, F., Rosenthal, F., & Eibl, D. (2019, July). Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.
Rossi, L. et al. (2019) ‘Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor’, in BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019. ZHAW Zürcher Hochschule für Angewandte Wissenschaften.
L. Rossi, C. Schirmer, M. Teale, F. Kurt, F. Rosenthal, and D. Eibl, “Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor,” in BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019, Jul. 2019.
ROSSI, Lia, Cedric SCHIRMER, Misha TEALE, Fabienne KURT, Florian ROSENTHAL und Dieter EIBL, 2019. Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor. In: BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019. Conference poster. ZHAW Zürcher Hochschule für Angewandte Wissenschaften. Juli 2019
Rossi, Lia, Cedric Schirmer, Misha Teale, Fabienne Kurt, Florian Rosenthal, and Dieter Eibl. 2019. “Proof of Concept Study for Cultivation of Strict Anaerobes in a Single-Use Wave-Mixed Bioreactor.” Conference poster. In BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019. ZHAW Zürcher Hochschule für Angewandte Wissenschaften.
Rossi, Lia, et al. “Proof of Concept Study for Cultivation of Strict Anaerobes in a Single-Use Wave-Mixed Bioreactor.” BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019, ZHAW Zürcher Hochschule für Angewandte Wissenschaften, 2019.
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