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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26838
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dc.contributor.authorPinelli, Filippo-
dc.contributor.authorPizzetti, Fabio-
dc.contributor.authorVeneruso, Valeria-
dc.contributor.authorPetillo, Emilia-
dc.contributor.authorRaghunath, Michael-
dc.contributor.authorPerale, Giuseppe-
dc.contributor.authorVeglianese, Pietro-
dc.contributor.authorRossi, Filippo-
dc.date.accessioned2023-02-09T11:34:16Z-
dc.date.available2023-02-09T11:34:16Z-
dc.date.issued2022-
dc.identifier.issn2227-9059de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26838-
dc.description.abstractSpinal cord injury (SCI) is an injurious process that begins with immediate physical damage to the spinal cord and associated tissues during an acute traumatic event. However, the tissue damage expands in both intensity and volume in the subsequent subacute phase. At this stage, numerous events exacerbate the pathological condition, and therein lies the main cause of post-traumatic neural degeneration, which then ends with the chronic phase. In recent years, therapeutic interventions addressing different neurodegenerative mechanisms have been proposed, but have met with limited success when translated into clinical settings. The underlying reasons for this are that the pathogenesis of SCI is a continued multifactorial disease, and the treatment of only one factor is not sufficient to curb neural degeneration and resulting paralysis. Recent advances have led to the development of biomaterials aiming to promote in situ combinatorial strategies using drugs/biomolecules to achieve a maximized multitarget approach. This review provides an overview of single and combinatorial regenerative-factor-based treatments as well as potential delivery options to treat SCIs.de_CH
dc.language.isoende_CH
dc.publisherMDPIde_CH
dc.relation.ispartofBiomedicinesde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectHydrogelde_CH
dc.subjectInflammationde_CH
dc.subjectNanoparticlede_CH
dc.subjectRegenerationde_CH
dc.subjectSpinal cordde_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.titleBiomaterial-mediated factor delivery for spinal cord injury treatmentde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.3390/biomedicines10071673de_CH
dc.identifier.doi10.21256/zhaw-26838-
dc.identifier.pmid35884981de_CH
zhaw.funding.euNode_CH
zhaw.issue7de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start1673de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume10de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMetabolic Tissue Engineeringde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Pinelli, F., Pizzetti, F., Veneruso, V., Petillo, E., Raghunath, M., Perale, G., Veglianese, P., & Rossi, F. (2022). Biomaterial-mediated factor delivery for spinal cord injury treatment. Biomedicines, 10(7), 1673. https://doi.org/10.3390/biomedicines10071673
Pinelli, F. et al. (2022) ‘Biomaterial-mediated factor delivery for spinal cord injury treatment’, Biomedicines, 10(7), p. 1673. Available at: https://doi.org/10.3390/biomedicines10071673.
F. Pinelli et al., “Biomaterial-mediated factor delivery for spinal cord injury treatment,” Biomedicines, vol. 10, no. 7, p. 1673, 2022, doi: 10.3390/biomedicines10071673.
PINELLI, Filippo, Fabio PIZZETTI, Valeria VENERUSO, Emilia PETILLO, Michael RAGHUNATH, Giuseppe PERALE, Pietro VEGLIANESE und Filippo ROSSI, 2022. Biomaterial-mediated factor delivery for spinal cord injury treatment. Biomedicines. 2022. Bd. 10, Nr. 7, S. 1673. DOI 10.3390/biomedicines10071673
Pinelli, Filippo, Fabio Pizzetti, Valeria Veneruso, Emilia Petillo, Michael Raghunath, Giuseppe Perale, Pietro Veglianese, and Filippo Rossi. 2022. “Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment.” Biomedicines 10 (7): 1673. https://doi.org/10.3390/biomedicines10071673.
Pinelli, Filippo, et al. “Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment.” Biomedicines, vol. 10, no. 7, 2022, p. 1673, https://doi.org/10.3390/biomedicines10071673.


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