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dc.contributor.authorRaghunath, Michael-
dc.contributor.authorZeugolis, Dimitrios I.-
dc.date.accessioned2023-02-24T13:28:05Z-
dc.date.available2023-02-24T13:28:05Z-
dc.date.issued2021-
dc.identifier.issn0968-0004de_CH
dc.identifier.issn1362-4326de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/27135-
dc.description.abstractIn multicellular organisms, the intracellular and extracellular spaces are considerably packed with a diverse range of macromolecular species. Yet, standard eukaryotic cell culture is performed in dilute, and deprived of macromolecules culture media, that barely imitate the density and complex macromolecular composition of tissues. Essentially, we drown cells in a sea of media and then expect them to perform physiologically. Herein, we argue the use of macromolecular crowding (MMC) in eukaryotic cell culture for regenerative medicine and drug discovery purposes.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofTrends in Biochemical Sciencesde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectCell culturede_CH
dc.subjectDrug discoveryde_CH
dc.subjectExcluded volume effectde_CH
dc.subjectExtracellular matrixde_CH
dc.subjectMacromolecular crowdingde_CH
dc.subjectRegenerative medicinede_CH
dc.subjectMacromolecular substancede_CH
dc.subjectEukaryotic Cellde_CH
dc.subjectExtracellular Matrixde_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.titleTransforming eukaryotic cell culture with macromolecular crowdingde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.tibs.2021.04.006de_CH
dc.identifier.pmid33994289de_CH
zhaw.funding.euNode_CH
zhaw.issue10de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end811de_CH
zhaw.pages.start805de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume46de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMetabolic Tissue Engineeringde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Raghunath, M., & Zeugolis, D. I. (2021). Transforming eukaryotic cell culture with macromolecular crowding. Trends in Biochemical Sciences, 46(10), 805–811. https://doi.org/10.1016/j.tibs.2021.04.006
Raghunath, M. and Zeugolis, D.I. (2021) ‘Transforming eukaryotic cell culture with macromolecular crowding’, Trends in Biochemical Sciences, 46(10), pp. 805–811. Available at: https://doi.org/10.1016/j.tibs.2021.04.006.
M. Raghunath and D. I. Zeugolis, “Transforming eukaryotic cell culture with macromolecular crowding,” Trends in Biochemical Sciences, vol. 46, no. 10, pp. 805–811, 2021, doi: 10.1016/j.tibs.2021.04.006.
RAGHUNATH, Michael und Dimitrios I. ZEUGOLIS, 2021. Transforming eukaryotic cell culture with macromolecular crowding. Trends in Biochemical Sciences. 2021. Bd. 46, Nr. 10, S. 805–811. DOI 10.1016/j.tibs.2021.04.006
Raghunath, Michael, and Dimitrios I. Zeugolis. 2021. “Transforming Eukaryotic Cell Culture with Macromolecular Crowding.” Trends in Biochemical Sciences 46 (10): 805–11. https://doi.org/10.1016/j.tibs.2021.04.006.
Raghunath, Michael, and Dimitrios I. Zeugolis. “Transforming Eukaryotic Cell Culture with Macromolecular Crowding.” Trends in Biochemical Sciences, vol. 46, no. 10, 2021, pp. 805–11, https://doi.org/10.1016/j.tibs.2021.04.006.


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