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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-27765
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dc.contributor.authorKoch, Franziska-
dc.contributor.authorWolff, Anne-
dc.contributor.authorMathes, Stephanie-
dc.contributor.authorPieles, Uwe-
dc.contributor.authorSaxer, Sina S.-
dc.contributor.authorKreikemeyer, Bernd-
dc.contributor.authorPeters, Kirsten-
dc.date.accessioned2023-04-28T13:17:07Z-
dc.date.available2023-04-28T13:17:07Z-
dc.date.issued2018-
dc.identifier.issn1176-9114de_CH
dc.identifier.issn1178-2013de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/27765-
dc.description.abstractBackground: The regeneration of tissue defects at the interface between soft and hard tissue, eg, in the periodontium, poses a challenge due to the divergent tissue requirements. A class of biomaterials that may support the regeneration at the soft-to-hard tissue interface are self-assembling peptides (SAPs), as their physicochemical and mechanical properties can be rationally designed to meet tissue requirements. Materials and methods: In this work, we investigated the effect of two single-component and two complementary β-sheet forming SAP systems on their hydrogel properties such as nanofibrillar architecture, surface charge, and protein adsorption as well as their influence on cell adhesion, morphology, growth, and differentiation. Results: We showed that these four 11-amino acid SAP (P11-SAP) hydrogels possessed physicochemical characteristics dependent on their amino acid composition that allowed variabilities in nanofibrillar network architecture, surface charge, and protein adsorption (eg, the single-component systems demonstrated an ~30% higher porosity and an almost 2-fold higher protein adsorption compared with the complementary systems). Cytocompatibility studies revealed similar results for cells cultured on the four P11-SAP hydrogels compared with cells on standard cell culture surfaces. The single-component P11-SAP systems showed a 1.7-fold increase in cell adhesion and cellular growth compared with the complementary P11-SAP systems. Moreover, significantly enhanced osteogenic differentiation of human calvarial osteoblasts was detected for the single-component P11-SAP system hydrogels compared with standard cell cultures. Conclusion: Thus, single-component system P11-SAP hydrogels can be assessed as suitable scaffolds for periodontal regeneration therapy, as they provide adjustable, extracellular matrix-mimetic nanofibrillar architecture and favorable cellular interaction with periodontal cells.de_CH
dc.language.isoende_CH
dc.publisherDove Medical Pressde_CH
dc.relation.ispartofInternational Journal of Nanomedicinede_CH
dc.rightshttp://creativecommons.org/licenses/by-nc/3.0/de_CH
dc.subjectP11-SAP hydrogelde_CH
dc.subjectSAPde_CH
dc.subjectCell proliferationde_CH
dc.subjectOsteogenic differentiationde_CH
dc.subjectperiodontal tissue regenerationde_CH
dc.subjectProtein adsorptionde_CH
dc.subjectSelf-assembling peptidede_CH
dc.subjectSurface chargede_CH
dc.subjectAmino acidde_CH
dc.subjectCell adhesionde_CH
dc.subjectCell differentiationde_CH
dc.subjectCells, culturedde_CH
dc.subjectExtracellular matrixde_CH
dc.subjectHumande_CH
dc.subjectHydrogelde_CH
dc.subjectIn vitro techniquede_CH
dc.subjectNanofiberde_CH
dc.subjectNeural stem cellde_CH
dc.subjectOsteoblastde_CH
dc.subjectPeptide fragmentde_CH
dc.subjectPeriodontiumde_CH
dc.subjectOsteogenesisde_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.titleAmino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitrode_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.2147/IJN.S173702de_CH
dc.identifier.doi10.21256/zhaw-27765-
dc.identifier.pmid30425485de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end6733de_CH
zhaw.pages.start6717de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume13de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Koch, F., Wolff, A., Mathes, S., Pieles, U., Saxer, S. S., Kreikemeyer, B., & Peters, K. (2018). Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro. International Journal of Nanomedicine, 13, 6717–6733. https://doi.org/10.2147/IJN.S173702
Koch, F. et al. (2018) ‘Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro’, International Journal of Nanomedicine, 13, pp. 6717–6733. Available at: https://doi.org/10.2147/IJN.S173702.
F. Koch et al., “Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro,” International Journal of Nanomedicine, vol. 13, pp. 6717–6733, 2018, doi: 10.2147/IJN.S173702.
KOCH, Franziska, Anne WOLFF, Stephanie MATHES, Uwe PIELES, Sina S. SAXER, Bernd KREIKEMEYER und Kirsten PETERS, 2018. Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro. International Journal of Nanomedicine. 2018. Bd. 13, S. 6717–6733. DOI 10.2147/IJN.S173702
Koch, Franziska, Anne Wolff, Stephanie Mathes, Uwe Pieles, Sina S. Saxer, Bernd Kreikemeyer, and Kirsten Peters. 2018. “Amino Acid Composition of Nanofibrillar Self-Assembling Peptide Hydrogels Affects Responses of Periodontal Tissue Cells in Vitro.” International Journal of Nanomedicine 13: 6717–33. https://doi.org/10.2147/IJN.S173702.
Koch, Franziska, et al. “Amino Acid Composition of Nanofibrillar Self-Assembling Peptide Hydrogels Affects Responses of Periodontal Tissue Cells in Vitro.” International Journal of Nanomedicine, vol. 13, 2018, pp. 6717–33, https://doi.org/10.2147/IJN.S173702.


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