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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-28264
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dc.contributor.authorBächinger, David-
dc.contributor.authorFilidoro, Noemi-
dc.contributor.authorNaville, Marc-
dc.contributor.authorJuchler, Norman-
dc.contributor.authorKurtcuoglu, Vartan-
dc.contributor.authorNadol, Joseph B.-
dc.contributor.authorSchuknecht, Bernhard-
dc.contributor.authorKleinjung, Tobias-
dc.contributor.authorVeraguth, Dorothe-
dc.contributor.authorEckhard, Andreas H.-
dc.date.accessioned2023-07-20T13:00:24Z-
dc.date.available2023-07-20T13:00:24Z-
dc.date.issued2023-06-26-
dc.identifier.issn2045-2322de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/28264-
dc.description.abstractWe aimed to determine the prevalence of radiological temporal bone features that in previous studies showed only a weak or an inconsistent association with the clinical diagnosis of Meniere's disease (MD), in two groups of MD patients (n = 71) with previously established distinct endolymphatic sac pathologies; i.e. the group MD-dg (ES degeneration) and the group MD-hp (ES hypoplasia). Delayed gadolinium-enhanced MRI and high-resolution CT data were used to determine and compare between and within (affected vs. non-affected side) groups geometric temporal bone features (lengths, widths, contours), air cell tract volume, height of the jugular bulb, sigmoid sinus width, and MRI signal intensity alterations of the ES. Temporal bone features with significant intergroup differences were the retrolabyrinthine bone thickness (1.04 ± 0.69 mm, MD-hp; 3.1 ± 1.9 mm, MD-dg; p < 0.0001); posterior contour tortuosity (mean arch-to-chord ratio 1.019 ± 0.013, MD-hp; 1.096 ± 0.038, MD-dg; p < 0.0001); and the pneumatized volume (1.37 [0.86] cm3, MD-hp; 5.25 [3.45] cm3, MD-dg; p = 0.03). Features with differences between the affected and non-affected sides within the MD-dg group were the sigmoid sinus width (6.5 ± 1.7 mm, affected; 7.6 ± 2.1 mm, non-affected; p = 0.04) and the MRI signal intensity of the endolymphatic sac (median signal intensity, affected vs. unaffected side, 0.59 [IQR 0.31-0.89]). Radiological temporal bone features known to be only weakly or inconsistently associated with the clinical diagnosis MD, are highly prevalent in either of two MD patient groups. These results support the existence of diverse-developmental and degenerative-disease etiologies manifesting with distinct radiological temporal bone abnormalities.de_CH
dc.language.isoende_CH
dc.publisherNature Publishing Groupde_CH
dc.relation.ispartofScientific Reportsde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectHumande_CH
dc.subjectTemporal bonede_CH
dc.subjectRadiographyde_CH
dc.subjectMagnetic resonance imagingde_CH
dc.subjectMeniere diseasede_CH
dc.subjectEndolymphatic sacde_CH
dc.subject.ddc617: Chirurgiede_CH
dc.titleRadiological feature heterogeneity supports etiological diversity among patient groups in Meniere's diseasede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1038/s41598-023-36479-5de_CH
dc.identifier.doi10.21256/zhaw-28264-
dc.identifier.pmid37365255de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start10303de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume13de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBiomedical Simulationde_CH
zhaw.webfeedDigital Health Labde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Bächinger, D., Filidoro, N., Naville, M., Juchler, N., Kurtcuoglu, V., Nadol, J. B., Schuknecht, B., Kleinjung, T., Veraguth, D., & Eckhard, A. H. (2023). Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease. Scientific Reports, 13(1), 10303. https://doi.org/10.1038/s41598-023-36479-5
Bächinger, D. et al. (2023) ‘Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease’, Scientific Reports, 13(1), p. 10303. Available at: https://doi.org/10.1038/s41598-023-36479-5.
D. Bächinger et al., “Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease,” Scientific Reports, vol. 13, no. 1, p. 10303, Jun. 2023, doi: 10.1038/s41598-023-36479-5.
BÄCHINGER, David, Noemi FILIDORO, Marc NAVILLE, Norman JUCHLER, Vartan KURTCUOGLU, Joseph B. NADOL, Bernhard SCHUKNECHT, Tobias KLEINJUNG, Dorothe VERAGUTH und Andreas H. ECKHARD, 2023. Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease. Scientific Reports. 26 Juni 2023. Bd. 13, Nr. 1, S. 10303. DOI 10.1038/s41598-023-36479-5
Bächinger, David, Noemi Filidoro, Marc Naville, Norman Juchler, Vartan Kurtcuoglu, Joseph B. Nadol, Bernhard Schuknecht, Tobias Kleinjung, Dorothe Veraguth, and Andreas H. Eckhard. 2023. “Radiological Feature Heterogeneity Supports Etiological Diversity among Patient Groups in Meniere’s Disease.” Scientific Reports 13 (1): 10303. https://doi.org/10.1038/s41598-023-36479-5.
Bächinger, David, et al. “Radiological Feature Heterogeneity Supports Etiological Diversity among Patient Groups in Meniere’s Disease.” Scientific Reports, vol. 13, no. 1, June 2023, p. 10303, https://doi.org/10.1038/s41598-023-36479-5.


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