LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach

Trifan, Adriana; Zengin, Gokhan; Sinan, Kouadio Ibrahime; Wolfram, Evelyn; Skalicka-Woźniak, Krystyna; Luca, Simon Vlad

doi:10.1016/j.jpba.2021.114283

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach
Authors:	Trifan, Adriana Zengin, Gokhan Sinan, Kouadio Ibrahime Wolfram, Evelyn Skalicka-Woźniak, Krystyna Luca, Simon Vlad
et. al:	No
DOI:	10.1016/j.jpba.2021.114283
Published in:	Journal of Pharmaceutical and Biomedical Analysis
Volume(Issue):	204
Page(s):	114283
Issue Date:	10-Sep-2021
Publisher / Ed. Institution:	Elsevier
ISSN:	07317085 1873-264X
Language:	English
Subjects:	Comfrey; Enzyme inhibitor; LC-HRMS/MS; Symphytum officinale; Antioxidant; Anchusa ochroleuca
Subject (DDC):	572: Biochemistry
Abstract:	This study was aimed at providing a comprehensive phytochemical characterization and multi-biological assessment of Symphytum officinale L., a medicinal plant with a noteworthy traditional use, and Anchusa ochroleuca M. Bieb., a Boraginaceae species from the Romanian flora. The dichloromethane, methanol and 65 % ethanol extracts obtained from the roots and aerial parts of both plants revealed the presence of numerous phenolic acids, oxygenated fatty acids, pyrrolizidine alkaloids (PAs) and flavonoids, as assessed by LC-HRMS/MS analysis. Consistent with their higher total phenolic content, the polar aerial part extracts of S. officinale and root extracts of A. ochroleuca showed the most significant antioxidant activities, as evaluated by DPPH (173.22-216.98 mg TE/g) and ABTS (219.41-311.97 mg TE/g) radical scavenging, CUPRAC (387.18-626.40 mg TE/g), FRAP (199.36-299.86 mg TE/g) and total antioxidant capacity (2.28-2.68 mmol TE/g). Furthermore, both plants exhibited good tyrosinase (19.11-43.89 mg KAE/g) and α-glucosidase (2.45-12.54 mmol ACAE/g) inhibitory effects. The orthogonal projections to latent structures discriminant analysis (OPLS-DA) allowed the objective differentiation between the roots and aerial parts of the two investigated species based on their phytochemical and biological profiles. The partial least square (PLS) analysis showed that several individual phenolic acids, such as danshensu, rabdosiin and rosmarinic acid, significantly contributed to the antioxidant potential of both Boraginaceae species, whilst the relative levels of sucrose were positively correlated with the anti-enzymatic properties. Overall, S. officinale and A. ochroleuca could be regarded as rich sources of bioactive phytochemicals that could further lead to developing novel phyto-pharmaceutical commodities.
URI:	https://digitalcollection.zhaw.ch/handle/11475/28374
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Trifan, A., Zengin, G., Sinan, K. I., Wolfram, E., Skalicka-Woźniak, K., & Luca, S. V. (2021). LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach. Journal of Pharmaceutical and Biomedical Analysis, 204, 114283. https://doi.org/10.1016/j.jpba.2021.114283

Trifan, A. et al. (2021) ‘LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach’, Journal of Pharmaceutical and Biomedical Analysis, 204, p. 114283. Available at: https://doi.org/10.1016/j.jpba.2021.114283.

A. Trifan, G. Zengin, K. I. Sinan, E. Wolfram, K. Skalicka-Woźniak, and S. V. Luca, “LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach,” Journal of Pharmaceutical and Biomedical Analysis, vol. 204, p. 114283, Sep. 2021, doi: 10.1016/j.jpba.2021.114283.

TRIFAN, Adriana, Gokhan ZENGIN, Kouadio Ibrahime SINAN, Evelyn WOLFRAM, Krystyna SKALICKA-WOŹNIAK und Simon Vlad LUCA, 2021. LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach. Journal of Pharmaceutical and Biomedical Analysis. 10 September 2021. Bd. 204, S. 114283. DOI 10.1016/j.jpba.2021.114283

Trifan, Adriana, Gokhan Zengin, Kouadio Ibrahime Sinan, Evelyn Wolfram, Krystyna Skalicka-Woźniak, and Simon Vlad Luca. 2021. “LC-HRMS/MS Phytochemical Profiling of Symphytum Officinale L. And Anchusa Ochroleuca M. Bieb. (Boraginaceae) : Unveiling Their Multi-Biological Potential via an Integrated Approach.” Journal of Pharmaceutical and Biomedical Analysis 204 (September): 114283. https://doi.org/10.1016/j.jpba.2021.114283.

Trifan, Adriana, et al. “LC-HRMS/MS Phytochemical Profiling of Symphytum Officinale L. And Anchusa Ochroleuca M. Bieb. (Boraginaceae) : Unveiling Their Multi-Biological Potential via an Integrated Approach.” Journal of Pharmaceutical and Biomedical Analysis, vol. 204, Sept. 2021, p. 114283, https://doi.org/10.1016/j.jpba.2021.114283.