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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-28453
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dc.contributor.authorWade-Bohleber, Laura-
dc.contributor.authorZoelch, Niklaus-
dc.contributor.authorLehmann, Mick-
dc.contributor.authorErnst, Jutta-
dc.contributor.authorRichter, André-
dc.contributor.authorSeifritz, Erich-
dc.contributor.authorBoeker, Heinz-
dc.contributor.authorGrimm, Simone-
dc.date.accessioned2023-08-11T14:29:48Z-
dc.date.available2023-08-11T14:29:48Z-
dc.date.issued2023-06-15-
dc.identifier.issn0302-282Xde_CH
dc.identifier.issn1423-0224de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/28453-
dc.description.abstractIntroduction: Psychodynamic psychotherapy is an effective and widely used treatment for major depressive disorder (MDD); however, little is known about neurobiological changes associated with induced symptom improvement. Methods: Proton magnetic resonance spectroscopy with a two-dimensional J-resolved sequence served to test the relationship between glutamate (Glu) and glutamine (Gln) levels, measured separately in pregenual anterior cingulate cortex (pgACC) and the anterior midcingulate cortex (aMCC) as a control region, with change in depression symptoms after 6 months of weekly psychodynamic psychotherapy sessions in MDD patients. Depressed (N = 45) and healthy (N = 30) subjects participated in a baseline proton magnetic resonance spectroscopy measurement and a subgroup of MDD subjects (N = 21) then received once-a-week psychodynamic psychotherapy and participated in a second proton magnetic resonance spectroscopy measurement after 6 months. Change in depression symptoms was assessed using the Hamilton Depression Rating Scale (HAMD). Results: Higher pretreatment pgACC Gln concentrations in MDD patients compared to healthy controls were associated with symptom severity. Patients and controls did not differ regarding Gln levels in aMCC nor regarding Glu levels in both regions. The association of pgACC Gln concentration and severity of depressive symptoms was reversed after 6 months of psychotherapy in MDD subjects. Regarding Gln in aMCC as well as Glu in both regions, there were no significant associations with improvement of depressive symptoms in the course of psychotherapy. Discussion: Findings indicate specific regional effects of psychodynamic psychotherapy on glutamatergic neurotransmission and thereby highlight the key role of the pgACC in both depression pathophysiology and recovery.de_CH
dc.language.isoende_CH
dc.publisherKargerde_CH
dc.relation.ispartofNeuropsychobiologyde_CH
dc.rightshttps://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectDepressionde_CH
dc.subjectGlutamatede_CH
dc.subjectGlutaminede_CH
dc.subjectProton magnetic resonance spectroscopyde_CH
dc.subjectPsychotherapyde_CH
dc.subject.ddc616.89: Psychische Störungen, klinische Psychologie und Psychiatriede_CH
dc.titleEffects of psychotherapy on glutamatergic neurotransmissionde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementAngewandte Psychologiede_CH
zhaw.organisationalunitPsychologisches Institut (PI)de_CH
dc.identifier.doi10.1159/000530312de_CH
dc.identifier.doi10.21256/zhaw-28453-
dc.identifier.pmid37321187de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end209de_CH
zhaw.pages.start203de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume82de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
zhaw.relation.referenceshttps://doi.org/10.48573/kfpv-pt95de_CH
Appears in collections:Publikationen Angewandte Psychologie

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Wade-Bohleber, L., Zoelch, N., Lehmann, M., Ernst, J., Richter, A., Seifritz, E., Boeker, H., & Grimm, S. (2023). Effects of psychotherapy on glutamatergic neurotransmission. Neuropsychobiology, 82(4), 203–209. https://doi.org/10.1159/000530312
Wade-Bohleber, L. et al. (2023) ‘Effects of psychotherapy on glutamatergic neurotransmission’, Neuropsychobiology, 82(4), pp. 203–209. Available at: https://doi.org/10.1159/000530312.
L. Wade-Bohleber et al., “Effects of psychotherapy on glutamatergic neurotransmission,” Neuropsychobiology, vol. 82, no. 4, pp. 203–209, Jun. 2023, doi: 10.1159/000530312.
WADE-BOHLEBER, Laura, Niklaus ZOELCH, Mick LEHMANN, Jutta ERNST, André RICHTER, Erich SEIFRITZ, Heinz BOEKER und Simone GRIMM, 2023. Effects of psychotherapy on glutamatergic neurotransmission. Neuropsychobiology. 15 Juni 2023. Bd. 82, Nr. 4, S. 203–209. DOI 10.1159/000530312
Wade-Bohleber, Laura, Niklaus Zoelch, Mick Lehmann, Jutta Ernst, André Richter, Erich Seifritz, Heinz Boeker, and Simone Grimm. 2023. “Effects of Psychotherapy on Glutamatergic Neurotransmission.” Neuropsychobiology 82 (4): 203–9. https://doi.org/10.1159/000530312.
Wade-Bohleber, Laura, et al. “Effects of Psychotherapy on Glutamatergic Neurotransmission.” Neuropsychobiology, vol. 82, no. 4, June 2023, pp. 203–9, https://doi.org/10.1159/000530312.


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