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https://doi.org/10.21256/zhaw-1692| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor |
| Authors: | Fischer, Thomas Riedl, Rainer |
| DOI: | 10.3390/molecules22091548 10.21256/zhaw-1692 |
| Published in: | Molecules |
| Volume(Issue): | 22 |
| Issue: | 9 |
| Issue Date: | 2017 |
| Publisher / Ed. Institution: | MDPI |
| ISSN: | 1420-3049 1433-1373 |
| Language: | English |
| Subjects: | Medicinal chemistry; Drug discovery; Inhibitor |
| Subject (DDC): | 615: Pharmacology and therapeutics |
| Abstract: | Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan. MMP-7 is a validated target for the development of small molecule drugs against cancer. MMP-13 is within the enzyme class the most efficient contributor to type II collagen degeneration and is a validated target in arthritis and cancer. We have developed the dual MMP-7/-13 inhibitor ZHAWOC6941 with IC50-values of 2.2 M (MMP-7) and 1.2 M (MMP-13) that is selective over a broad range of MMP isoforms. It spares MMP-1, -2, -3, -8, -9, -12 and -14, making it a valuable modulator for targeted polypharmacology approaches. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2895 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2017_Fischer_Development of a non-hydroxamate dual matrix metalloproteinase_Molecules.pdf | 1.83 MB | Adobe PDF |  View/Open |
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Fischer, T., & Riedl, R. (2017). Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor. Molecules, 22(9). https://doi.org/10.3390/molecules22091548
Fischer, T. and Riedl, R. (2017) ‘Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor’, Molecules, 22(9). Available at: https://doi.org/10.3390/molecules22091548.
T. Fischer and R. Riedl, “Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor,” Molecules, vol. 22, no. 9, 2017, doi: 10.3390/molecules22091548.
FISCHER, Thomas und Rainer RIEDL, 2017. Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor. Molecules. 2017. Bd. 22, Nr. 9. DOI 10.3390/molecules22091548
Fischer, Thomas, and Rainer Riedl. 2017. “Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.” Molecules 22 (9). https://doi.org/10.3390/molecules22091548.
Fischer, Thomas, and Rainer Riedl. “Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.” Molecules, vol. 22, no. 9, 2017, https://doi.org/10.3390/molecules22091548.
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