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  2. Life Sciences und Facility Management
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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorInfanger, Sophia-
dc.contributor.authorHämmerli, Alexander-
dc.contributor.authorIliev, Simona-
dc.contributor.authorBaier, Andrea-
dc.contributor.authorStoyanov, Edmont-
dc.contributor.authorQuodbach, Julian-
dc.date.accessioned2023-11-01T16:26:27Z-
dc.date.available2023-11-01T16:26:27Z-
dc.date.issued2018-
dc.identifier.issn0378-5173de_CH
dc.identifier.issn1873-3476de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/29006-
dc.description.abstract3D-printing is a promising tool to pave the way to the widespread adaption of individualized medicine. Several printing techniques have been investigated and introduced to pharmaceutical research. Until now, only one 3D-printed medicine is approved on the US market. The medicine is manufactured via drop-on-powder deposition, which uses inkjet printing to jet a liquid binder on a powder bed to create 3D objects. However, inkjet processes are prone to nozzle clogging when binders or active pharmaceutical ingredients (APIs) are included in the printing ink. This renders the formulation development of the ink the most challenging step. In this study, different hydroxypropyl cellulose (HPC) grades were investigated as solid binders in the powder formulation on a commercially available DoP printer. The printed ink only consisted of a water/ethanol mixture. Formulations containing 70% caffeine as model API were developed and tablets printed. It was found that the friability of the tablets greatly depends on the particle size of the employed binder, whereas disintegration time and dissolution properties mainly depend on the viscosity of the employed binders. Higher viscous binders led to slower disintegration and dissolution whereas lower viscous binders led to faster disintegration and dissolution. The study demonstrates that HPC is a suitable solid binder for DoP printing and that 3D-DoP printing can be used to print robust dosage forms.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofInternational Journal of Pharmaceuticsde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject3D-printingde_CH
dc.subjectBinder freede_CH
dc.subjectDrop-on-powderde_CH
dc.subjectDrop-on-solidde_CH
dc.subjectIndividualized medicinede_CH
dc.subjectInkjetde_CH
dc.subjectChemistry, pharmaceuticalde_CH
dc.subjectDrug liberationde_CH
dc.subjectSurface propertyde_CH
dc.subjectTechnology, pharmaceuticalde_CH
dc.subjectDrug delivery systemde_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.titlePowder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binderde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.ijpharm.2018.11.048de_CH
dc.identifier.pmid30458260de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end206de_CH
zhaw.pages.start198de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume555de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPharmazeutische Technologiede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Infanger, S., Hämmerli, A., Iliev, S., Baier, A., Stoyanov, E., & Quodbach, J. (2018). Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder. International Journal of Pharmaceutics, 555, 198–206. https://doi.org/10.1016/j.ijpharm.2018.11.048
Infanger, S. et al. (2018) ‘Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder’, International Journal of Pharmaceutics, 555, pp. 198–206. Available at: https://doi.org/10.1016/j.ijpharm.2018.11.048.
S. Infanger, A. Hämmerli, S. Iliev, A. Baier, E. Stoyanov, and J. Quodbach, “Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder,” International Journal of Pharmaceutics, vol. 555, pp. 198–206, 2018, doi: 10.1016/j.ijpharm.2018.11.048.
INFANGER, Sophia, Alexander HÄMMERLI, Simona ILIEV, Andrea BAIER, Edmont STOYANOV und Julian QUODBACH, 2018. Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder. International Journal of Pharmaceutics. 2018. Bd. 555, S. 198–206. DOI 10.1016/j.ijpharm.2018.11.048
Infanger, Sophia, Alexander Hämmerli, Simona Iliev, Andrea Baier, Edmont Stoyanov, and Julian Quodbach. 2018. “Powder Bed 3D-Printing of Highly Loaded Drug Delivery Devices with Hydroxypropyl Cellulose as Solid Binder.” International Journal of Pharmaceutics 555: 198–206. https://doi.org/10.1016/j.ijpharm.2018.11.048.
Infanger, Sophia, et al. “Powder Bed 3D-Printing of Highly Loaded Drug Delivery Devices with Hydroxypropyl Cellulose as Solid Binder.” International Journal of Pharmaceutics, vol. 555, 2018, pp. 198–206, https://doi.org/10.1016/j.ijpharm.2018.11.048.


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