Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis

Chen, Wenjia; Anothaisintawee, Thunyarat; Butani, Dimple; Wang, Yi; Zemlyanska, Yaroslava; Wong, Chong Boon Nigel; Virabhak, Suchin; Hrishikesh, M. A.; Teerawattananon, Yot

doi:10.1136/bmjopen-2021-057537

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29246

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis
Authors:	Chen, Wenjia Anothaisintawee, Thunyarat Butani, Dimple Wang, Yi Zemlyanska, Yaroslava Wong, Chong Boon Nigel Virabhak, Suchin Hrishikesh, M. A. Teerawattananon, Yot
et. al:	No
DOI:	10.1136/bmjopen-2021-057537 10.21256/zhaw-29246
Published in:	BMJ Open
Volume(Issue):	12
Issue:	4
Page(s):	e057537
Issue Date:	5-Apr-2022
Publisher / Ed. Institution:	BMJ Publishing Group
ISSN:	2044-6055
Language:	English
Subjects:	Genetics; Health economics; Public health; Cost-benefit analysis
Subject (DDC):	362.1041: Health economics
Abstract:	Introduction: Precision medicine (PM) involves gene testing to identify disease risk, enable early diagnosis or guide therapeutic choice, and targeted gene therapy. We aim to perform a systematic review and meta-analysis to quantify the cost-effectiveness profile of PM stratified by intervention type, identify sources of heterogeneity in the value-for-money of PM. Methods and analysis: We will perform a systematic search in Embase, MEDLINE, EconLit and CRD databases for studies published in English language or with translation in English between 1 January 2011 and 8 July 2021 on the topic of cost-effectiveness analysis of PM interventions. The focus will be on studies that reported health and economic outcomes. Study quality will be assessed using the Biases in Economic Studies checklist. The incremental net benefit of PM screening, diagnostic, treatment-targeting and therapeutic interventions over conventional strategies will be respectively pooled across studies using a random-effect model if heterogeneity is present, otherwise a fixed-effect model. Subgroup analyses will be performed based on disease area, WHO region and World Bank country-income level. Additionally, we will identify the potential sources of heterogeneity with random-effect meta-regressions. Finally, biases will be detected using jackknife sensitivity analysis, funnel plot assessment and Egger’s tests. Ethics and dissemination: For this type of study ethics approval or formal consent is not required. The results will be disseminated at various presentations and feedback sessions, in conference abstracts and manuscripts that will be submitted to peer-reviewed journals.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29246
Fulltext version:	Published version
License (according to publishing contract):	CC BY-NC 4.0: Attribution - Non commercial 4.0 International
Departement:	School of Management and Law
Organisational Unit:	Winterthur Institute of Health Economics (WIG)
Appears in collections:	Publikationen School of Management and Law

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Chen, W., Anothaisintawee, T., Butani, D., Wang, Y., Zemlyanska, Y., Wong, C. B. N., Virabhak, S., Hrishikesh, M. A., & Teerawattananon, Y. (2022). Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis. BMJ Open, 12(4), e057537. https://doi.org/10.1136/bmjopen-2021-057537

Chen, W. et al. (2022) ‘Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis’, BMJ Open, 12(4), p. e057537. Available at: https://doi.org/10.1136/bmjopen-2021-057537.

W. Chen et al., “Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis,” BMJ Open, vol. 12, no. 4, p. e057537, Apr. 2022, doi: 10.1136/bmjopen-2021-057537.

CHEN, Wenjia, Thunyarat ANOTHAISINTAWEE, Dimple BUTANI, Yi WANG, Yaroslava ZEMLYANSKA, Chong Boon Nigel WONG, Suchin VIRABHAK, M. A. HRISHIKESH und Yot TEERAWATTANANON, 2022. Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis. BMJ Open. 5 April 2022. Bd. 12, Nr. 4, S. e057537. DOI 10.1136/bmjopen-2021-057537

Chen, Wenjia, Thunyarat Anothaisintawee, Dimple Butani, Yi Wang, Yaroslava Zemlyanska, Chong Boon Nigel Wong, Suchin Virabhak, M. A. Hrishikesh, and Yot Teerawattananon. 2022. “Assessing the Cost-Effectiveness of Precision Medicine : Protocol for a Systematic Review and Meta-Analysis.” BMJ Open 12 (4): e057537. https://doi.org/10.1136/bmjopen-2021-057537.

Chen, Wenjia, et al. “Assessing the Cost-Effectiveness of Precision Medicine : Protocol for a Systematic Review and Meta-Analysis.” BMJ Open, vol. 12, no. 4, Apr. 2022, p. e057537, https://doi.org/10.1136/bmjopen-2021-057537.