From nature to industry : harnessing enzymes for biocatalysis

Buller, R.; Lutz, S.; Kazlauskas, R. J.; Snajdrova, R.; Moore, J. C.; Bornscheuer, U. T.

doi:10.1126/science.adh8615

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	From nature to industry : harnessing enzymes for biocatalysis
Authors:	Buller, R. Lutz, S. Kazlauskas, R. J. Snajdrova, R. Moore, J. C. Bornscheuer, U. T.
et. al:	No
DOI:	10.1126/science.adh8615
Published in:	Science
Volume(Issue):	382
Issue:	6673
Page(s):	eadh8615
Issue Date:	24-Nov-2023
Publisher / Ed. Institution:	American Association for the Advancement of Science
ISSN:	0036-8075 1095-9203
Language:	English
Subjects:	Methanol; Technology; Substrate specificity; Biocatalysis; Enzyme; Protein engineering
Subject (DDC):	660.6: Biotechnology
Abstract:	Biocatalysis harnesses enzymes to make valuable products. This green technology is used in countless applications from bench scale to industrial production and allows practitioners to access complex organic molecules, often with fewer synthetic steps and reduced waste. The last decade has seen an explosion in the development of experimental and computational tools to tailor enzymatic properties, equipping enzyme engineers with the ability to create biocatalysts that perform reactions not present in nature. By using (chemo)-enzymatic synthesis routes or orchestrating intricate enzyme cascades, scientists can synthesize elaborate targets ranging from DNA and complex pharmaceuticals to starch made in vitro from CO2-derived methanol. In addition, new chemistries have emerged through the combination of biocatalysis with transition metal catalysis, photocatalysis, and electrocatalysis. This review highlights recent key developments, identifies current limitations, and provides a future prospect for this rapidly developing technology.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29457
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

Files in This Item:

There are no files associated with this item.

Show full item record

Buller, R., Lutz, S., Kazlauskas, R. J., Snajdrova, R., Moore, J. C., & Bornscheuer, U. T. (2023). From nature to industry : harnessing enzymes for biocatalysis. Science, 382(6673), eadh8615. https://doi.org/10.1126/science.adh8615

Buller, R. et al. (2023) ‘From nature to industry : harnessing enzymes for biocatalysis’, Science, 382(6673), p. eadh8615. Available at: https://doi.org/10.1126/science.adh8615.

R. Buller, S. Lutz, R. J. Kazlauskas, R. Snajdrova, J. C. Moore, and U. T. Bornscheuer, “From nature to industry : harnessing enzymes for biocatalysis,” Science, vol. 382, no. 6673, p. eadh8615, Nov. 2023, doi: 10.1126/science.adh8615.

BULLER, R., S. LUTZ, R. J. KAZLAUSKAS, R. SNAJDROVA, J. C. MOORE und U. T. BORNSCHEUER, 2023. From nature to industry : harnessing enzymes for biocatalysis. Science. 24 November 2023. Bd. 382, Nr. 6673, S. eadh8615. DOI 10.1126/science.adh8615

Buller, R., S. Lutz, R. J. Kazlauskas, R. Snajdrova, J. C. Moore, and U. T. Bornscheuer. 2023. “From Nature to Industry : Harnessing Enzymes for Biocatalysis.” Science 382 (6673): eadh8615. https://doi.org/10.1126/science.adh8615.

Buller, R., et al. “From Nature to Industry : Harnessing Enzymes for Biocatalysis.” Science, vol. 382, no. 6673, Nov. 2023, p. eadh8615, https://doi.org/10.1126/science.adh8615.