Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review

Seidel, Stefan; Schirmer, Cedric; Maschke, Rüdiger; Rossi, Lia; Eibl-Schindler, Regine; Eibl, Dieter

doi:10.5772/intechopen.109848

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29536

Full metadata record

DC Field	Value	Language
dc.contributor.author	Seidel, Stefan	-
dc.contributor.author	Schirmer, Cedric	-
dc.contributor.author	Maschke, Rüdiger	-
dc.contributor.author	Rossi, Lia	-
dc.contributor.author	Eibl-Schindler, Regine	-
dc.contributor.author	Eibl, Dieter	-
dc.date.accessioned	2024-01-10T15:35:48Z	-
dc.date.available	2024-01-10T15:35:48Z	-
dc.date.issued	2023-02-14	-
dc.identifier.isbn	978-1-80355-654-3	de_CH
dc.identifier.isbn	978-1-80355-655-0	de_CH
dc.identifier.uri	https://digitalcollection.zhaw.ch/handle/11475/29536	-
dc.description.abstract	Computational fluid dynamics (CFD) is a widely used tool for investigating fluid flows in bioreactors. It has been used in the biopharmaceutical industry for years and has established itself as an important tool for process engineering characterisation. As a result, CFD simulations are increasingly being used to complement classical process engineering investigations in the laboratory with spatially and temporally resolved results, or even replace them when laboratory investigations are not possible. Parameters that can be determined include the specific power input, Kolmogorov length, hydrodynamic stress, mixing time, oxygen transfer rate, and for cultivations with microcarriers, the NS1 criterion. In the first part of this series, a literature review illustrates how these parameters can be determined using CFD and how they can be validated experimentally. In addition, an overview of the hardware and software typically used for bioreactor characterisation will also be provided, including process engineering parameter investigations from the literature. In the second part of this series, the authors’ research results will be used to show how the process engineering characterisation of mechanically driven bioreactors for the biopharmaceutical industry (stirred, orbitally shaken, and wave-mixed) can be determined and validated using CFD.	de_CH
dc.language.iso	en	de_CH
dc.publisher	IntechOpen Limited	de_CH
dc.relation.ispartof	Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications	de_CH
dc.rights	http://creativecommons.org/licenses/by/3.0/	de_CH
dc.subject	Mixing time	de_CH
dc.subject	Oxygen mass transfer	de_CH
dc.subject	Power input	de_CH
dc.subject	Process engineering characterisation	de_CH
dc.subject	Single-use bioreactor	de_CH
dc.subject	Validation	de_CH
dc.subject	Verfahrenstechnik	de_CH
dc.subject.ddc	660: Technische Chemie	de_CH
dc.title	Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review	de_CH
dc.type	Buchbeitrag	de_CH
dcterms.type	Text	de_CH
zhaw.departement	Life Sciences und Facility Management	de_CH
zhaw.organisationalunit	Institut für Chemie und Biotechnologie (ICBT)	de_CH
zhaw.publisher.place	London	de_CH
dc.identifier.doi	10.5772/intechopen.109848	de_CH
dc.identifier.doi	10.21256/zhaw-29536	-
zhaw.funding.eu	No	de_CH
zhaw.originated.zhaw	Yes	de_CH
zhaw.pages.end	82	de_CH
zhaw.pages.start	53	de_CH
zhaw.parentwork.editor	Ji, Guozhao	-
zhaw.parentwork.editor	Dong, Jingliang	-
zhaw.publication.status	publishedVersion	de_CH
zhaw.publication.review	Peer review (Publikation)	de_CH
zhaw.author.additional	No	de_CH
zhaw.display.portrait	Yes	de_CH
Appears in collections:	Publikationen Life Sciences und Facility Management

Files in This Item:

File	Description	Size	Format
2023_Seidel-etal_CFD-Bioreactors-PartI-Literature-Review_IntechOpen.pdf		4.23 MB	Adobe PDF	View/Open

Show simple item record

Seidel, S., Schirmer, C., Maschke, R., Rossi, L., Eibl-Schindler, R., & Eibl, D. (2023). Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review. In G. Ji & J. Dong (Eds.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications (pp. 53–82). IntechOpen Limited. https://doi.org/10.5772/intechopen.109848

Seidel, S. et al. (2023) ‘Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review’, in G. Ji and J. Dong (eds) Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications. London: IntechOpen Limited, pp. 53–82. Available at: https://doi.org/10.5772/intechopen.109848.

S. Seidel, C. Schirmer, R. Maschke, L. Rossi, R. Eibl-Schindler, and D. Eibl, “Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review,” in Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, G. Ji and J. Dong, Eds. London: IntechOpen Limited, 2023, pp. 53–82. doi: 10.5772/intechopen.109848.

SEIDEL, Stefan, Cedric SCHIRMER, Rüdiger MASCHKE, Lia ROSSI, Regine EIBL-SCHINDLER und Dieter EIBL, 2023. Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review. In: Guozhao JI und Jingliang DONG (Hrsg.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications. London: IntechOpen Limited. S. 53–82. ISBN 978-1-80355-654-3

Seidel, Stefan, Cedric Schirmer, Rüdiger Maschke, Lia Rossi, Regine Eibl-Schindler, and Dieter Eibl. 2023. “Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry : Part I: Literature Review.” In Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, edited by Guozhao Ji and Jingliang Dong, 53–82. London: IntechOpen Limited. https://doi.org/10.5772/intechopen.109848.

Seidel, Stefan, et al. “Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry : Part I: Literature Review.” Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, edited by Guozhao Ji and Jingliang Dong, IntechOpen Limited, 2023, pp. 53–82, https://doi.org/10.5772/intechopen.109848.