Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo

Silva Oliveira, Ana Gabriela; Andrade Rocha, Marina; Santos de Azevedo, Lucas; Thaynara de Moura Coelho, Aline; Russo Chagas, Rafael César; Batista Santos, Hélio; Gruppi Thomé, Ralph; Peter, Samuel; Wolfram, Evelyn; Kim, Bonglee; Reis, Rui Manuel; de Azambuja Ribeiro, Rosy Iara Maciel

doi:10.1055/a-2181-2569

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo
Authors:	Silva Oliveira, Ana Gabriela Andrade Rocha, Marina Santos de Azevedo, Lucas Thaynara de Moura Coelho, Aline Russo Chagas, Rafael César Batista Santos, Hélio Gruppi Thomé, Ralph Peter, Samuel Wolfram, Evelyn Kim, Bonglee Reis, Rui Manuel de Azambuja Ribeiro, Rosy Iara Maciel
et. al:	No
DOI:	10.1055/a-2181-2569
Published in:	Planta Medica
Volume(Issue):	90
Issue:	1
Page(s):	13
Pages to:	24
Issue Date:	2023
Publisher / Ed. Institution:	Thieme
ISSN:	0032-0943 1439-0221
Language:	English
Subjects:	Plant extract; Angiogenesis; Apoptosis; Cell line, Tumor; Glioblastoma; Plants, Medicinal; Antineoplastic agent
Subject (DDC):	615: Pharmacology and therapeutics
Abstract:	Glioblastoma is the most frequent primary malignant brain tumor without effective treatment, which makes this work extremely relevant. The study of the bioactive compounds from medicinal plants plays an important role in the discovery of new drugs.This research investigated the constituents of Tapirira guianensis and its antitumor potential (in vitro and in vivo) in glioblastoma. The T. guianensis extracts were characterized by mass spectrometry. The ethyl acetate partition (01ID) and its fractions 01ID-F2 and 01ID-F4 from T. guianensis showed potential antitumor treatment evidenced by selective cytotoxicity for GAMG with IC50 14.1 µg/mL, 83.07 µg/mL, 59.27 µg/mL and U251 with IC50 25.92 µg/mL, 37.3 µg/mL and 18.84 µg/mL. Fractions 01ID-F2 and 01ID-F4 were 10 times more selective when compared to TMZ and 01ID for the two evaluated cell lines. T. guianensis also reduced matrix metalloproteinases 2 - 01ID-F2 (21.84%), 01ID-F4 (29.6%) and 9 - 01ID-F4 (73.42%), ID-F4 (53.84%) activities, and induced apoptosis mainly through the extrinsic pathway. Furthermore, all treatments significantly reduced tumor size (01ID p < 0,01, 01ID-F2 p < 0,01 and 01ID-F4 p < 0,0001) and caused blood vessels to shrink in vivo. The present findings highlight that T. guianensis exhibits considerable antitumor potential in preclinical studies of glioblastoma. This ability may be related to the phenolic compounds and sesquiterpene derivatives identified in the extracts. This study deserves further in vivo research, followed by clinical investigation.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29641
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Silva Oliveira, A. G., Andrade Rocha, M., Santos de Azevedo, L., Thaynara de Moura Coelho, A., Russo Chagas, R. C., Batista Santos, H., Gruppi Thomé, R., Peter, S., Wolfram, E., Kim, B., Reis, R. M., & de Azambuja Ribeiro, R. I. M. (2023). Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo. Planta Medica, 90(1), 13–24. https://doi.org/10.1055/a-2181-2569

Silva Oliveira, A.G. et al. (2023) ‘Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo’, Planta Medica, 90(1), pp. 13–24. Available at: https://doi.org/10.1055/a-2181-2569.

A. G. Silva Oliveira et al., “Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo,” Planta Medica, vol. 90, no. 1, pp. 13–24, 2023, doi: 10.1055/a-2181-2569.

SILVA OLIVEIRA, Ana Gabriela, Marina ANDRADE ROCHA, Lucas SANTOS DE AZEVEDO, Aline THAYNARA DE MOURA COELHO, Rafael César RUSSO CHAGAS, Hélio BATISTA SANTOS, Ralph GRUPPI THOMÉ, Samuel PETER, Evelyn WOLFRAM, Bonglee KIM, Rui Manuel REIS und Rosy Iara Maciel DE AZAMBUJA RIBEIRO, 2023. Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo. Planta Medica. 2023. Bd. 90, Nr. 1, S. 13–24. DOI 10.1055/a-2181-2569

Silva Oliveira, Ana Gabriela, Marina Andrade Rocha, Lucas Santos de Azevedo, Aline Thaynara de Moura Coelho, Rafael César Russo Chagas, Hélio Batista Santos, Ralph Gruppi Thomé, et al. 2023. “Tapirira Guianensis Is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in Vivo.” Planta Medica 90 (1): 13–24. https://doi.org/10.1055/a-2181-2569.

Silva Oliveira, Ana Gabriela, et al. “Tapirira Guianensis Is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in Vivo.” Planta Medica, vol. 90, no. 1, 2023, pp. 13–24, https://doi.org/10.1055/a-2181-2569.