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  4. Publikationen Angewandte Psychologie
Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29657
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dc.contributor.authorKamp, Caroline Barkholt-
dc.contributor.authorPetersen, Johanne Juul-
dc.contributor.authorFaltermeier, Pascal-
dc.contributor.authorJuul, Sophie-
dc.contributor.authorSiddiqui, Faiza-
dc.contributor.authorBarbateskovic, Marija-
dc.contributor.authorKristensen, Andreas Torp-
dc.contributor.authorMoncrieff, Joanna-
dc.contributor.authorHorowitz, Mark Abie-
dc.contributor.authorHengartner, Michael Pascal-
dc.contributor.authorKirsch, Irving-
dc.contributor.authorGluud, Christian-
dc.contributor.authorJakobsen, Janus Christian-
dc.date.accessioned2024-01-27T13:25:12Z-
dc.date.available2024-01-27T13:25:12Z-
dc.date.issued2024-
dc.identifier.issn2755-9734de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/29657-
dc.description.abstractQuestion: Tricyclic antidepressants are used to treat depression worldwide, but the adverse effects have not been systematically assessed. Our objective was to assess the beneficial and harmful effects of all tricyclic antidepressants for adults with major depressive disorder. Study selection and analysis: We conducted a systematic review with meta-analysis and trial sequential analysis. We searched CENTRAL, MEDLINE, Embase, LILACS and other sources from inception to January 2023 for randomised clinical trials comparing tricyclic antidepressants versus placebo or ‘active placebo’ for adults with major depressive disorder. The primary outcomes were depressive symptoms measured on the 17-item Hamilton Depression Rating Scale (HDRS-17), serious adverse events and quality of life. The minimal important difference was defined as three points on the HDRS-17. Findings: We included 103 trials randomising 10 590 participants. All results were at high risk of bias, and the certainty of the evidence was very low or low. All trials only assessed outcomes at the end of the treatment period at a maximum of 12 weeks after randomisation. Meta-analysis and trial sequential analysis showed evidence of a beneficial effect of tricyclic antidepressants compared with placebo (mean difference −3.77 HDRS-17 points; 95% CI −5.91 to −1.63; 17 trials). Meta-analysis showed evidence of a harmful effect of tricyclic antidepressants compared with placebo on serious adverse events (OR 2.78; 95% CI 2.18 to 3.55; 35 trials), but the required information size was not reached. Only 2 out of 103 trials reported on quality of life and t-tests showed no evidence of a difference. Conclusions: The long-term effects of tricyclic antidepressants and the effects on quality of life are unknown. Short-term results suggest that tricyclic antidepressants may reduce depressive symptoms while also increasing the risks of serious adverse events, but these results were based on low and very low certainty evidence.de_CH
dc.language.isoende_CH
dc.publisherBMJ Publishing Groupde_CH
dc.relation.ispartofBMJ Mental Healthde_CH
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/de_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.subject.ddc616.8: Neurologie und Krankheiten des Nervensystemsde_CH
dc.titleBeneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysisde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementAngewandte Psychologiede_CH
zhaw.organisationalunitPsychologisches Institut (PI)de_CH
dc.identifier.doi10.1136/bmjment-2023-300730de_CH
dc.identifier.doi10.21256/zhaw-29657-
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.starte300730de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume27de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedKlinische Psychologiede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Angewandte Psychologie

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Kamp, C. B., Petersen, J. J., Faltermeier, P., Juul, S., Siddiqui, F., Barbateskovic, M., Kristensen, A. T., Moncrieff, J., Horowitz, M. A., Hengartner, M. P., Kirsch, I., Gluud, C., & Jakobsen, J. C. (2024). Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis. BMJ Mental Health, 27(1), e300730. https://doi.org/10.1136/bmjment-2023-300730
Kamp, C.B. et al. (2024) ‘Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis’, BMJ Mental Health, 27(1), p. e300730. Available at: https://doi.org/10.1136/bmjment-2023-300730.
C. B. Kamp et al., “Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis,” BMJ Mental Health, vol. 27, no. 1, p. e300730, 2024, doi: 10.1136/bmjment-2023-300730.
KAMP, Caroline Barkholt, Johanne Juul PETERSEN, Pascal FALTERMEIER, Sophie JUUL, Faiza SIDDIQUI, Marija BARBATESKOVIC, Andreas Torp KRISTENSEN, Joanna MONCRIEFF, Mark Abie HOROWITZ, Michael Pascal HENGARTNER, Irving KIRSCH, Christian GLUUD und Janus Christian JAKOBSEN, 2024. Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis. BMJ Mental Health. 2024. Bd. 27, Nr. 1, S. e300730. DOI 10.1136/bmjment-2023-300730
Kamp, Caroline Barkholt, Johanne Juul Petersen, Pascal Faltermeier, Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Andreas Torp Kristensen, et al. 2024. “Beneficial and Harmful Effects of Tricyclic Antidepressants for Adults with Major Depressive Disorder : A Systematic Review with Meta-Analysis and Trial Sequential Analysis.” BMJ Mental Health 27 (1): e300730. https://doi.org/10.1136/bmjment-2023-300730.
Kamp, Caroline Barkholt, et al. “Beneficial and Harmful Effects of Tricyclic Antidepressants for Adults with Major Depressive Disorder : A Systematic Review with Meta-Analysis and Trial Sequential Analysis.” BMJ Mental Health, vol. 27, no. 1, 2024, p. e300730, https://doi.org/10.1136/bmjment-2023-300730.


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