Circle of Willis configurations in stroke patients

Musio, Fabio; Juchler, Norman; Yang, Kaiyuan; Menze, Björn; Hirsch, Sven

Publication type:	Conference other
Type of review:	Peer review (abstract)
Title:	Circle of Willis configurations in stroke patients
Authors:	Musio, Fabio Juchler, Norman Yang, Kaiyuan Menze, Björn Hirsch, Sven
et. al:	No
Conference details:	19th Interdisciplinary Cerebrovascular Symposium, Geneva, Switzerland, 17-19 August 2023
Issue Date:	18-Aug-2023
Language:	English
Subjects:	Circle of Willis; Ischemic Stroke; Vessel Segmentation; Virtual reality
Subject (DDC):	006: Special computer methods 610: Medicine and health
Abstract:	Aims: The Circle of Willis (CoW) is an arterial anastomotic system formed by the principal arteries in the brain. Anatomical variants of the CoW are frequent and occur in a large part of the general population [1]. Not only does the length and caliber of vessel segments change, also the topology of the vessel tree is subject to variation. It is hypothesized that CoW variants can have an impact on the severity of stroke [2; 3]. As a first step in studying this relation we present a pipeline for annotating and extracting the CoW vessels in 3D angiographies and show some preliminary results on the topological variability in a stroke cohort. Methods: Leveraging the power of virtual reality (VR) we developed an efficient protocol for the 3D anatomical annotation of the CoW in MRA and CTA. This way we carefully annotated the CoW in a cohort of 115 stroke patients with dual imaging modalities, allowing us to analyze the CoW topological variability. Results: The results are twofold: (1) We present our dataset containing complete CoW vessel annotations on two common angiographic imaging modalities. This dataset is made publicly available [4] to help facilitate future CoW research. (2) As part of our preliminary analysis on the CoW topological variability we find all types of variants in our stroke cohort. The most common one was the absence of the posterior communicating arteries (Pcom). A complete CoW was found in less than 30% of the cohort. Outlook: We believe that our dataset can be of benefit to both clinicians and medical imaging researchers. Good quality data is critical for large-scale CoW characterization and the study of the effect of the angioarchitecture on cerebrovascular diseases.
Further description:	References: [1] Lars B. Hindenes et al. Variations in the circle of willis in a large population sample using 3D TOF angiography: The tromsø study. PLoS One, 15(11), 2020. [2] A. W. J. Hoksbergen et al. Absent collateral function of the circle of willis as risk factor for ischemic stroke. Cerebrovascular Diseases, 16(3):191–198, 2003. [3] T. van Seeters et al. Completeness of the circle of willis and risk of ischemic stroke in patients without cerebrovascular disease. Neuroradiology, 57:1247–1251, 2015. [4] Topcow: Topology-aware anatomical segmentation of the circle of willis for CTA and MRA. MICCAI 2023. https://topcow23.grand-challenge.org/topcow23/.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29854
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Computational Life Sciences (ICLS)
Published as part of the ZHAW project:	Deep Brain Vessel Profiler
Appears in collections:	Publikationen Life Sciences und Facility Management

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Musio, F., Juchler, N., Yang, K., Menze, B., & Hirsch, S. (2023, August 18). Circle of Willis configurations in stroke patients. 19th Interdisciplinary Cerebrovascular Symposium, Geneva, Switzerland, 17-19 August 2023.

Musio, F. et al. (2023) ‘Circle of Willis configurations in stroke patients’, in 19th Interdisciplinary Cerebrovascular Symposium, Geneva, Switzerland, 17-19 August 2023.

F. Musio, N. Juchler, K. Yang, B. Menze, and S. Hirsch, “Circle of Willis configurations in stroke patients,” in 19th Interdisciplinary Cerebrovascular Symposium, Geneva, Switzerland, 17-19 August 2023, Aug. 2023.

MUSIO, Fabio, Norman JUCHLER, Kaiyuan YANG, Björn MENZE und Sven HIRSCH, 2023. Circle of Willis configurations in stroke patients. In: 19th Interdisciplinary Cerebrovascular Symposium, Geneva, Switzerland, 17-19 August 2023. Conference presentation. 18 August 2023

Musio, Fabio, Norman Juchler, Kaiyuan Yang, Björn Menze, and Sven Hirsch. 2023. “Circle of Willis Configurations in Stroke Patients.” Conference presentation. In 19th Interdisciplinary Cerebrovascular Symposium, Geneva, Switzerland, 17-19 August 2023.

Musio, Fabio, et al. “Circle of Willis Configurations in Stroke Patients.” 19th Interdisciplinary Cerebrovascular Symposium, Geneva, Switzerland, 17-19 August 2023, 2023.