1. ZHAW digitalcollection
  2. Life Sciences und Facility Management
  3. Publikationen
  4. Publikationen Life Sciences und Facility Management
Full metadata record
DC FieldValueLanguage
dc.contributor.authorStehlin, Jonas-
dc.contributor.authorPeter, Samuel-
dc.contributor.authorAlbert, Ina-
dc.contributor.authorVahekeni, Nina-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorFrei-Haller, Barbara-
dc.contributor.authorLardos, Andreas-
dc.date.accessioned2024-02-15T13:01:20Z-
dc.date.available2024-02-15T13:01:20Z-
dc.date.issued2023-
dc.identifier.issn0032-0943de_CH
dc.identifier.issn1439-0221de_CH
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/29912-
dc.description.abstractAn ex vivo screening effort using plants from the “Arzneibuch von Hallwyl” (ABvH), an influential recipe text from 16th-century Switzerland, was carried out with the goal of exploring the immunomodulatory potential of medicinal plants that have largely fallen out of use in modern practice. An ex vivo screening model using a human whole blood assay (WBA) stimulated with LPS was chosen to measure perturbation of IL-6 release in 21 preparations, 5 of which were directly based on recipes from the ABvH. Candidates with promising activity were then to be tested in LPS-activated human PBMC for comparison with the results of the WBA. MTT assay was chosen to characterise the cytotoxic profile of active extracts. Eight of the 21 tested samples showed heterogenous effects on IL-6 release in the WBA. In the PBMC assay the 80% EtOH extract from the roots of Vincetoxicum hirundinaria Medik. (VHR) showed the strongest ex vivo inhibition with an IC50 of 3.62±0.47 μg/mL. Results of the MTT assay in NIH-3T3 fibroblasts suggest a minor cytotoxic potential of most samples. The data gathered during this study points to promising ex vivo immunomodulatory activity exhibited by the active samples and rationalises further screening efforts based on plants from the ABvH.de_CH
dc.language.isoende_CH
dc.publisherThiemede_CH
dc.relation.ispartofPlanta Medicade_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectPflanzede_CH
dc.subjectArzneimittelde_CH
dc.subjectSchweizde_CH
dc.subject16. Jahrhundertde_CH
dc.subject.ddc580: Pflanzen (Botanik)de_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleImmunomodulatory studies on selected plants from the Hallwyl "Kräuterbuch" : an influential recipe text from 16th century Switzerlandde_CH
dc.typeKonferenz: Posterde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.conference.details71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Dublin, Ireland, 2–5 July 2023de_CH
zhaw.funding.euNode_CH
zhaw.issue14de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1393de_CH
zhaw.pages.start1392de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume89de_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
zhaw.webfeedPhytopharmaziede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.
Show simple item record
Stehlin, J., Peter, S., Albert, I., Vahekeni, N., Wolfram, E., Frei-Haller, B., & Lardos, A. (2023). Immunomodulatory studies on selected plants from the Hallwyl “Kräuterbuch” : an influential recipe text from 16th century Switzerland [Conference poster]. Planta Medica, 89(14), 1392–1393. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171
Stehlin, J. et al. (2023) ‘Immunomodulatory studies on selected plants from the Hallwyl ‘Kräuterbuch’ : an influential recipe text from 16th century Switzerland’, in Planta Medica. Thieme, pp. 1392–1393. Available at: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171.
J. Stehlin et al., “Immunomodulatory studies on selected plants from the Hallwyl “Kräuterbuch” : an influential recipe text from 16th century Switzerland,” in Planta Medica, 2023, vol. 89, no. 14, pp. 1392–1393. [Online]. Available: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171
STEHLIN, Jonas, Samuel PETER, Ina ALBERT, Nina VAHEKENI, Evelyn WOLFRAM, Barbara FREI-HALLER und Andreas LARDOS, 2023. Immunomodulatory studies on selected plants from the Hallwyl „Kräuterbuch“ : an influential recipe text from 16th century Switzerland. In: Planta Medica [online]. Conference poster. Thieme. 2023. S. 1392–1393. Verfügbar unter: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171
Stehlin, Jonas, Samuel Peter, Ina Albert, Nina Vahekeni, Evelyn Wolfram, Barbara Frei-Haller, and Andreas Lardos. 2023. “Immunomodulatory Studies on Selected Plants from the Hallwyl “Kräuterbuch” : An Influential Recipe Text from 16th Century Switzerland.” Conference poster. In Planta Medica, 89:1392–93. Thieme. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171.
Stehlin, Jonas, et al. “Immunomodulatory Studies on Selected Plants from the Hallwyl “Kräuterbuch” : An Influential Recipe Text from 16th Century Switzerland.” Planta Medica, vol. 89, no. 14, Thieme, 2023, pp. 1392–93, https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.