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  2. Life Sciences und Facility Management
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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorJossen, Valentin-
dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorBroccard, Gilles-
dc.contributor.authorEibl, Dieter-
dc.date.accessioned2024-03-09T09:50:37Z-
dc.date.available2024-03-09T09:50:37Z-
dc.date.issued2023-
dc.identifier.isbn978-3-031-45668-8de_CH
dc.identifier.isbn978-3-031-45669-5de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/30136-
dc.description.abstractSingle-use systems have become increasingly important in recent years. This applies in particular to their use in the manufacture of biopharmaceutical products based on mammalian cell cultures, such as antibodies for the therapy of cancer and autoimmune diseases. Today, developers and manufacturers of such biotherapeutics can choose from a large product portfolio of single-use systems from different suppliers. For example, there are single-use versions of storage bags, filters, mixers, bioreactors, connectors, harvesting and transfer systems, membrane adsorbers, freeze- and -thaw systems, to name just a few examples. Thus, the production of clinical samples in complete single-use production facilities (upstream processing to filling) is already a reality. Based on the definition of the term and the presentation of milestones in the development of single-use technology, the book chapter discusses the most important advantages and existing limitations of the single-use systems currently available on the market. Subsequently, the current state of development of single-use technology is presented on the basis of selected product examples. The focus is on the upstream area and single-use bioreactors. Finally, approaches for process intensification up to complete continuous production resulting from the increasing implementation of single-use systems are deduced.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofBiopharmaceutical Manufacturing : Progress, Trends and Challengesde_CH
dc.relation.ispartofseriesCell Engineeringde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBiopharmaceuticalsde_CH
dc.subjectDownstreamingde_CH
dc.subjectFill & finishde_CH
dc.subjectProcess intensificationde_CH
dc.subjectSingle-usede_CH
dc.subjectUpstreamingde_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleSingle-use systems in biopharmaceutical manufacture : state of the art and recent trendsde_CH
dc.typeBuchbeitragde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeChamde_CH
dc.identifier.doi10.1007/978-3-031-45669-5_1de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end38de_CH
zhaw.pages.start3de_CH
zhaw.parentwork.editorPörtner, Ralf-
zhaw.publication.statuspublishedVersionde_CH
zhaw.series.number11de_CH
zhaw.publication.reviewEditorial reviewde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Jossen, V., Eibl-Schindler, R., Broccard, G., & Eibl, D. (2023). Single-use systems in biopharmaceutical manufacture : state of the art and recent trends. In R. Pörtner (Ed.), Biopharmaceutical Manufacturing : Progress, Trends and Challenges (pp. 3–38). Springer. https://doi.org/10.1007/978-3-031-45669-5_1
Jossen, V. et al. (2023) ‘Single-use systems in biopharmaceutical manufacture : state of the art and recent trends’, in R. Pörtner (ed.) Biopharmaceutical Manufacturing : Progress, Trends and Challenges. Cham: Springer, pp. 3–38. Available at: https://doi.org/10.1007/978-3-031-45669-5_1.
V. Jossen, R. Eibl-Schindler, G. Broccard, and D. Eibl, “Single-use systems in biopharmaceutical manufacture : state of the art and recent trends,” in Biopharmaceutical Manufacturing : Progress, Trends and Challenges, R. Pörtner, Ed. Cham: Springer, 2023, pp. 3–38. doi: 10.1007/978-3-031-45669-5_1.
JOSSEN, Valentin, Regine EIBL-SCHINDLER, Gilles BROCCARD und Dieter EIBL, 2023. Single-use systems in biopharmaceutical manufacture : state of the art and recent trends. In: Ralf PÖRTNER (Hrsg.), Biopharmaceutical Manufacturing : Progress, Trends and Challenges. Cham: Springer. S. 3–38. ISBN 978-3-031-45668-8
Jossen, Valentin, Regine Eibl-Schindler, Gilles Broccard, and Dieter Eibl. 2023. “Single-Use Systems in Biopharmaceutical Manufacture : State of the Art and Recent Trends.” In Biopharmaceutical Manufacturing : Progress, Trends and Challenges, edited by Ralf Pörtner, 3–38. Cham: Springer. https://doi.org/10.1007/978-3-031-45669-5_1.
Jossen, Valentin, et al. “Single-Use Systems in Biopharmaceutical Manufacture : State of the Art and Recent Trends.” Biopharmaceutical Manufacturing : Progress, Trends and Challenges, edited by Ralf Pörtner, Springer, 2023, pp. 3–38, https://doi.org/10.1007/978-3-031-45669-5_1.


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