1. ZHAW digitalcollection
  2. Life Sciences und Facility Management
  3. Publikationen
  4. Publikationen Life Sciences und Facility Management
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMiron, A.-
dc.contributor.authorAelenei, P.-
dc.contributor.authorTrifan, A.-
dc.contributor.authorRimbu, C.M.-
dc.contributor.authorHorhogea, C.E.-
dc.contributor.authorLuca, S.V.-
dc.contributor.authorNeagu, A.N.-
dc.contributor.authorWolfram, E.-
dc.contributor.authorAprotosoaie, A.C.-
dc.date.accessioned2024-03-27T12:30:44Z-
dc.date.available2024-03-27T12:30:44Z-
dc.date.issued2019-09-04-
dc.identifier.issn1439-0221de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/30381-
dc.description.abstractCombination of conventional antibiotics with natural products represents a promising strategy in overcoming antibiotic resistance. The aim of this work was to assess the interactions between plant-derived products and several antibiotics in order to identify potential synergistic antibacterial combinations. Both extracts and pure phytochemicals were included in this study. The effects of the combinations were evaluated against Gram-positive including methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria. Our studies on essential oils showed that coriander essential oil and its major constituent, linalool, acted synergistically with several antibiotics (oxacillin, gentamicin, tetracycline, ciprofloxacin) against both Gram-positive and Gram-negative bacteria with coriander essential oil reversing tetracycline resistance of Staphylococcus epidermitis [2]. Despite its moderate antibacterial activity, white mulberry leaf ethanolic extract was found to reverse oxacillin resistance of MRSA and to act synergistically with gentamicin against MRSA. Additionally, the extract showed synergy with gentamicin and tetracycline against Staphylococcus epidermitis [3]. Two of its constituents, namely morusin and kuwanon G, also reversed oxacillin resistance of MRSA and acted synergistically with gentamicin, tetracycline and ciprofloxacin against MRSA. Morusin also reversed tetracycline resistance of Staphylococcus epidermitis. Both morusin and kuwanon G increased the permeability of the bacterial membrane as shown by fluorescence and differential interference contrast microscopy. Conclusion: Plant-derived products are promising candidates for the development of novel treatment strategies in bacterial infections.de_CH
dc.language.isoende_CH
dc.publisherThiemede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titlePlant-derived products as antibiotic enhancers and antibiotic-resistance modifying agentsde_CH
dc.typeKonferenz: Sonstigesde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1055/s-0039-3399721de_CH
zhaw.conference.details67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP, Innsbruck, Austria, 1-5 September 2019de_CH
zhaw.funding.euNode_CH
zhaw.issue18de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start1422de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume85de_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
zhaw.title.proceedingsPlanta Medicade_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.
Show simple item record
Miron, A., Aelenei, P., Trifan, A., Rimbu, C. M., Horhogea, C. E., Luca, S. V., Neagu, A. N., Wolfram, E., & Aprotosoaie, A. C. (2019). Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents [Conference presentation]. Planta Medica, 85(18), 1422. https://doi.org/10.1055/s-0039-3399721
Miron, A. et al. (2019) ‘Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents’, in Planta Medica. Thieme, p. 1422. Available at: https://doi.org/10.1055/s-0039-3399721.
A. Miron et al., “Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents,” in Planta Medica, Sep. 2019, vol. 85, no. 18, p. 1422. doi: 10.1055/s-0039-3399721.
MIRON, A., P. AELENEI, A. TRIFAN, C.M. RIMBU, C.E. HORHOGEA, S.V. LUCA, A.N. NEAGU, E. WOLFRAM und A.C. APROTOSOAIE, 2019. Plant-derived products as antibiotic enhancers and antibiotic-resistance modifying agents. In: Planta Medica. Conference presentation. Thieme. 4 September 2019. S. 1422
Miron, A., P. Aelenei, A. Trifan, C.M. Rimbu, C.E. Horhogea, S.V. Luca, A.N. Neagu, E. Wolfram, and A.C. Aprotosoaie. 2019. “Plant-Derived Products as Antibiotic Enhancers and Antibiotic-Resistance Modifying Agents.” Conference presentation. In Planta Medica, 85:1422. Thieme. https://doi.org/10.1055/s-0039-3399721.
Miron, A., et al. “Plant-Derived Products as Antibiotic Enhancers and Antibiotic-Resistance Modifying Agents.” Planta Medica, vol. 85, no. 18, Thieme, 2019, p. 1422, https://doi.org/10.1055/s-0039-3399721.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.