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dc.contributor.authorRohrer, Jack-
dc.contributor.authorSchweizer, Anja-
dc.contributor.authorJohnson, Karl F.-
dc.contributor.authorKornfeld, Stuart-
dc.date.accessioned2018-06-13T09:32:56Z-
dc.date.available2018-06-13T09:32:56Z-
dc.date.issued1995-09-15-
dc.identifier.issn0021-9525de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/6831-
dc.description.abstractThe bovine cation-dependent mannose 6-phosphate receptor (CD-MPR) is a type 1 transmembrane protein that cycles between the trans-Golgi network, endosomes, and the plasma membrane. When the terminal 40 residues were deleted from the 67-amino acid cytoplasmic tail of the CD-MPR, the half-life of the receptor was drastically decreased and the mutant receptor was recovered in lysosomes. Analysis of additional cytoplasmic tail truncation mutants and alanine-scanning mutants implicated amino acids 34-39 as being critical for avoidance of lysosomal degradation. The cytoplasmic tail of the CD-MPR was partially effective in preventing the lysosomal membrane protein Lamp1 from entering lysosomes. Complete exclusion required both the CD-MPR cytoplasmic tail and transmembrane domain. The transmembrane domain alone had just a minor effect on the distribution of Lamp1. These findings indicate that the cytoplasmic tail of the CD-MPR contains a signal that prevents the receptor from trafficking to lysosomes. The transmembrane domain of the CD-MPR also contributes to this function.de_CH
dc.language.isoende_CH
dc.publisherRockefeller University Pressde_CH
dc.relation.ispartofJournal of Cell Biologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleA determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
dc.identifier.doi10.1083/jcb.130.6.1297de_CH
zhaw.funding.euNode_CH
zhaw.issue6de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1306de_CH
zhaw.pages.start1297de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume130de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Rohrer, J., Schweizer, A., Johnson, K. F., & Kornfeld, S. (1995). A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes. Journal of Cell Biology, 130(6), 1297–1306. https://doi.org/10.1083/jcb.130.6.1297
Rohrer, J. et al. (1995) ‘A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes’, Journal of Cell Biology, 130(6), pp. 1297–1306. Available at: https://doi.org/10.1083/jcb.130.6.1297.
J. Rohrer, A. Schweizer, K. F. Johnson, and S. Kornfeld, “A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes,” Journal of Cell Biology, vol. 130, no. 6, pp. 1297–1306, Sep. 1995, doi: 10.1083/jcb.130.6.1297.
ROHRER, Jack, Anja SCHWEIZER, Karl F. JOHNSON und Stuart KORNFELD, 1995. A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes. Journal of Cell Biology. 15 September 1995. Bd. 130, Nr. 6, S. 1297–1306. DOI 10.1083/jcb.130.6.1297
Rohrer, Jack, Anja Schweizer, Karl F. Johnson, and Stuart Kornfeld. 1995. “A Determinant in the Cytoplasmic Tail of the Cation-Dependent Mannose 6-Phosphate Receptor Prevents Trafficking to Lysosomes.” Journal of Cell Biology 130 (6): 1297–1306. https://doi.org/10.1083/jcb.130.6.1297.
Rohrer, Jack, et al. “A Determinant in the Cytoplasmic Tail of the Cation-Dependent Mannose 6-Phosphate Receptor Prevents Trafficking to Lysosomes.” Journal of Cell Biology, vol. 130, no. 6, Sept. 1995, pp. 1297–306, https://doi.org/10.1083/jcb.130.6.1297.


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