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dc.contributor.authorGarcia, Victor-
dc.contributor.authorGlassberg, Emily C.-
dc.contributor.authorHarpak, Arbel-
dc.contributor.authorFeldman, Marcus W.-
dc.date.accessioned2018-06-28T14:55:43Z-
dc.date.available2018-06-28T14:55:43Z-
dc.date.issued2018-03-21-
dc.identifier.issn1742-5689de_CH
dc.identifier.issn1742-5662de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/7498-
dc.description.abstractWithin-host adaptation of pathogens such as human immunodeficiency virus (HIV) often occurs at more than two loci. Multiple beneficial mutations may arise simultaneously on different genetic backgrounds and interfere, affecting each other's fixation trajectories. Here, we explore how these evolutionary dynamics are mirrored in multilocus linkage disequilibrium (MLD), a measure of multi-way associations between alleles. In the parameter regime corresponding to HIV, we show that deterministic early infection models induce MLD to oscillate over time in a wavelet-like fashion. We find that the frequency of these oscillations is proportional to the rate of adaptation. This signature is robust to drift, but can be eroded by high variation in fitness effects of beneficial mutations. Our findings suggest that MLD oscillations could be used as a signature of interference among multiple equally advantageous mutations and may aid the interpretation of MLD in data.de_CH
dc.language.isoende_CH
dc.publisherThe Royal Societyde_CH
dc.relation.ispartofJournal of the Royal Society Interfacede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectGenetic interferencede_CH
dc.subjectHuman immunodeficiency virusde_CH
dc.subjectMultilocus linkage disequilibriumde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleClonal interference can cause wavelet-like oscillations of multilocus linkage disequilibriumde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1098/rsif.2017.0921de_CH
dc.identifier.pmid29563246de_CH
zhaw.funding.euNode_CH
zhaw.issue140de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume15de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.funding.snfP2EZP3_162257de_CH
zhaw.webfeedApplied Mathematical Biologyde_CH
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Garcia, V., Glassberg, E. C., Harpak, A., & Feldman, M. W. (2018). Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium. Journal of the Royal Society Interface, 15(140). https://doi.org/10.1098/rsif.2017.0921
Garcia, V. et al. (2018) ‘Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium’, Journal of the Royal Society Interface, 15(140). Available at: https://doi.org/10.1098/rsif.2017.0921.
V. Garcia, E. C. Glassberg, A. Harpak, and M. W. Feldman, “Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium,” Journal of the Royal Society Interface, vol. 15, no. 140, Mar. 2018, doi: 10.1098/rsif.2017.0921.
GARCIA, Victor, Emily C. GLASSBERG, Arbel HARPAK und Marcus W. FELDMAN, 2018. Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium. Journal of the Royal Society Interface. 21 März 2018. Bd. 15, Nr. 140. DOI 10.1098/rsif.2017.0921
Garcia, Victor, Emily C. Glassberg, Arbel Harpak, and Marcus W. Feldman. 2018. “Clonal Interference Can Cause Wavelet-like Oscillations of Multilocus Linkage Disequilibrium.” Journal of the Royal Society Interface 15 (140). https://doi.org/10.1098/rsif.2017.0921.
Garcia, Victor, et al. “Clonal Interference Can Cause Wavelet-like Oscillations of Multilocus Linkage Disequilibrium.” Journal of the Royal Society Interface, vol. 15, no. 140, Mar. 2018, https://doi.org/10.1098/rsif.2017.0921.


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