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DC Field | Value | Language |
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dc.contributor.author | Gatti, Lorenzo | - |
dc.contributor.author | Zhang, Jitao David | - |
dc.contributor.author | Anisimova, Maria | - |
dc.contributor.author | Schutten, Martin | - |
dc.contributor.author | Osterhaus, Albert | - |
dc.contributor.author | van der Vries, Erhard | - |
dc.date.accessioned | 2018-07-10T12:56:34Z | - |
dc.date.available | 2018-07-10T12:56:34Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/7796 | - |
dc.description.abstract | Several human pathogens exhibit distinct patterns of seasonality and circulate as pairs of discrete strains. For instance, the activity of the two co-circulating influenza A virus subtypes oscillates and peaks during winter seasons of the worlds temperate climate zones. These periods of increased activity are usually caused by a single dominant subtype. Alternation of dominant strains in successive influenza seasons makes epidemic forecasting a major challenge. From the start of the 2009 influenza pandemic we enrolled influenza A virus infected patients (n = 2,980) in a global prospective clinical study. Complete hemagglutinin (HA) sequences were obtained from 1,078 A/H1N1 and 1,033 A/H3N2 viruses and were linked to patient data. We then used phylodynamics to construct high resolution spatio-temporal phylogenetic HA trees and estimated global influenza A effective reproductive numbers (R) over time (2009-2013). We demonstrate that R, a parameter to define host immunity, oscillates around R = 1 with a clear opposed alternation pattern between phases of the A/H1N1 and A/H3N2 subtypes. Moreover, we find a similar alternation pattern for the number of global virus migration events between the sampled geographical locations. Both observations suggest a between-strain competition for susceptible hosts on a global level. Extrinsic factors that affect person-to-person transmission are a major driver of influenza seasonality, which forces influenza epidemics to coincide with winter seasons. The data presented here indicate that also cross-reactive host immunity is a key intrinsic driver of global influenza seasonality, which determines the outcome of competition between influenza A virus strains at the onset of each epidemic season. | de_CH |
dc.language.iso | en | de_CH |
dc.rights | Licence according to publishing contract | de_CH |
dc.subject.ddc | 003: Systeme | de_CH |
dc.subject.ddc | 610: Medizin und Gesundheit | de_CH |
dc.title | Cross-reactive immunity drives global oscillation and opposed alternation patterns of seasonal influenza A viruses | de_CH |
dc.type | Weiteres (textuelles Material) | de_CH |
dcterms.type | Text | de_CH |
zhaw.departement | Life Sciences und Facility Management | de_CH |
zhaw.organisationalunit | Institut für Computational Life Sciences (ICLS) | de_CH |
dc.identifier.doi | 10.1101/226613 | de_CH |
zhaw.funding.eu | No | de_CH |
zhaw.originated.zhaw | Yes | de_CH |
zhaw.publication.status | submittedVersion | de_CH |
zhaw.webfeed | Computational Genomics | de_CH |
Appears in collections: | Publikationen Life Sciences und Facility Management |
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Gatti, L., Zhang, J. D., Anisimova, M., Schutten, M., Osterhaus, A., & van der Vries, E. (2017). Cross-reactive immunity drives global oscillation and opposed alternation patterns of seasonal influenza A viruses. https://doi.org/10.1101/226613
Gatti, L. et al. (2017) Cross-reactive immunity drives global oscillation and opposed alternation patterns of seasonal influenza A viruses. Available at: https://doi.org/10.1101/226613.
L. Gatti, J. D. Zhang, M. Anisimova, M. Schutten, A. Osterhaus, and E. van der Vries, Cross-reactive immunity drives global oscillation and opposed alternation patterns of seasonal influenza A viruses. 2017. doi: 10.1101/226613.
GATTI, Lorenzo, Jitao David ZHANG, Maria ANISIMOVA, Martin SCHUTTEN, Albert OSTERHAUS und Erhard VAN DER VRIES, 2017. Cross-reactive immunity drives global oscillation and opposed alternation patterns of seasonal influenza A viruses
Gatti, Lorenzo, Jitao David Zhang, Maria Anisimova, Martin Schutten, Albert Osterhaus, and Erhard van der Vries. 2017. Cross-Reactive Immunity Drives Global Oscillation and Opposed Alternation Patterns of Seasonal Influenza A Viruses. https://doi.org/10.1101/226613.
Gatti, Lorenzo, et al. Cross-Reactive Immunity Drives Global Oscillation and Opposed Alternation Patterns of Seasonal Influenza A Viruses. 2017, https://doi.org/10.1101/226613.
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