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|dc.contributor.author||Zhang, Jitao David||-|
|dc.contributor.author||van der Vries, Erhard||-|
|dc.description.abstract||Several human pathogens exhibit distinct patterns of seasonality and circulate as pairs of discrete strains. For instance, the activity of the two co-circulating influenza A virus subtypes oscillates and peaks during winter seasons of the worlds temperate climate zones. These periods of increased activity are usually caused by a single dominant subtype. Alternation of dominant strains in successive influenza seasons makes epidemic forecasting a major challenge. From the start of the 2009 influenza pandemic we enrolled influenza A virus infected patients (n = 2,980) in a global prospective clinical study. Complete hemagglutinin (HA) sequences were obtained from 1,078 A/H1N1 and 1,033 A/H3N2 viruses and were linked to patient data. We then used phylodynamics to construct high resolution spatio-temporal phylogenetic HA trees and estimated global influenza A effective reproductive numbers (R) over time (2009-2013). We demonstrate that R, a parameter to define host immunity, oscillates around R = 1 with a clear opposed alternation pattern between phases of the A/H1N1 and A/H3N2 subtypes. Moreover, we find a similar alternation pattern for the number of global virus migration events between the sampled geographical locations. Both observations suggest a between-strain competition for susceptible hosts on a global level. Extrinsic factors that affect person-to-person transmission are a major driver of influenza seasonality, which forces influenza epidemics to coincide with winter seasons. The data presented here indicate that also cross-reactive host immunity is a key intrinsic driver of global influenza seasonality, which determines the outcome of competition between influenza A virus strains at the onset of each epidemic season.||de_CH|
|dc.rights||Licence according to publishing contract||de_CH|
|dc.subject.ddc||610: Medizin und Gesundheit||de_CH|
|dc.title||Cross-reactive immunity drives global oscillation and opposed alternation patterns of seasonal influenza A viruses||de_CH|
|dc.type||Weiteres (textuelles Material)||de_CH|
|zhaw.departement||Life Sciences und Facility Management||de_CH|
|zhaw.organisationalunit||Institut für Computational Life Sciences (ICLS)||de_CH|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
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