Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3881
Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Darwin and Fisher meet at biotech : on the potential of computational molecular evolution in industry
Authors: Anisimova, Maria
DOI: 10.21256/zhaw-3881
10.1186/s12862-015-0352-y
Published in: BMC Evolutionary Biology
Volume(Issue): 15
Page(s): 76
Pages to: 85
Issue Date: 2015
Publisher / Ed. Institution: BioMed Central
ISSN: 1471-2148
Language: English
Subjects: Animal; Biotechnology; Computational biology; Human; Metabolome; Proteins; Genetic selection; Molecular evolution; Genomics
Subject (DDC): 570: Biology
660.6: Biotechnology
Abstract: Today computational molecular evolution is a vibrant research field that benefits from the availability of large and complex new generation sequencing data - ranging from full genomes and proteomes to microbiomes, metabolomes and epigenomes. The grounds for this progress were established long before the discovery of the DNA structure. Specifically, Darwin's theory of evolution by means of natural selection not only remains relevant today, but also provides a solid basis for computational research with a variety of applications. But a long-term progress in biology was ensured by the mathematical sciences, as exemplified by Sir R. Fisher in early 20th century. Now this is true more than ever: The data size and its complexity require biologists to work in close collaboration with experts in computational sciences, modeling and statistics.
URI: 
https://digitalcollection.zhaw.ch/handle/11475/8257
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Computational Life Sciences (ICLS)
Appears in collections:Publikationen Life Sciences und Facility Management

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