Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3888
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dc.contributor.authorRech, Gabriel E.-
dc.contributor.authorSanz-Martín, José M.-
dc.contributor.authorAnisimova, Maria-
dc.contributor.authorSukno, Serenella A.-
dc.contributor.authorThon, Michael R.-
dc.date.accessioned2018-07-17T15:16:11Z-
dc.date.available2018-07-17T15:16:11Z-
dc.date.issued2014-
dc.identifier.issn1759-6653de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/8275-
dc.description.abstractNatural selection leaves imprints on DNA, offering the opportunity to identify functionally important regions of the genome. Identifying the genomic regions affected by natural selection within pathogens can aid in the pursuit of effective strategies to control diseases. In this study, we analyzed genome-wide patterns of selection acting on different classes of sequences in a worldwide sample of eight strains of the model plant-pathogenic fungus Colletotrichum graminicola. We found evidence of selective sweeps, balancing selection, and positive selection affecting both protein-coding and noncoding DNA of pathogenicity-related sequences. Genes encoding putative effector proteins and secondary metabolite biosynthetic enzymes show evidence of positive selection acting on the coding sequence, consistent with an Arms Race model of evolution. The 5′ untranslated regions (UTRs) of genes coding for effector proteins and genes upregulated during infection show an excess of high-frequency polymorphisms likely the consequence of balancing selection and consistent with the Red Queen hypothesis of evolution acting on these putative regulatory sequences. Based on the findings of this work, we propose that even though adaptive substitutions on coding sequences are important for proteins that interact directly with the host, polymorphisms in the regulatory sequences may confer flexibility of gene expression in the virulence processes of this important plant pathogen.de_CH
dc.language.isoende_CH
dc.publisherOxford University Pressde_CH
dc.relation.ispartofGenome Biology and Evolutionde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectPositive selectionde_CH
dc.subjectPAMLde_CH
dc.subjectColletotrichum graminicolade_CH
dc.subjectPathogenicityde_CH
dc.subjectArms race hypothesisde_CH
dc.subject.ddc570: Biologiede_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleNatural selection at coding and non-coding DNA mainly affects pathogenicity-related genes in the hemibiotrophic fungus Colletotrichum graminicolade_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.21256/zhaw-3888-
dc.identifier.doi10.1093/gbe/evu192de_CH
zhaw.funding.euNode_CH
zhaw.issue9de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end2379de_CH
zhaw.pages.start2368de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume6de_CH
zhaw.publication.reviewNot specifiedde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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