Age- and level-dependence of fatty infiltration in lumbar paravertebral muscles of healthy volunteers

Crawford, Rebecca J.; Filli, L.; Elliott, J.M.; Nanz, D.; Fischer, M.A.; Marcon, M.; Ulbrich, E.J.

doi:10.3174/ajnr.A4596

Full metadata record

DC Field	Value	Language
dc.contributor.author	Crawford, Rebecca J.	-
dc.contributor.author	Filli, L.	-
dc.contributor.author	Elliott, J.M.	-
dc.contributor.author	Nanz, D.	-
dc.contributor.author	Fischer, M.A.	-
dc.contributor.author	Marcon, M.	-
dc.contributor.author	Ulbrich, E.J.	-
dc.date.accessioned	2018-10-08T13:23:46Z	-
dc.date.available	2018-10-08T13:23:46Z	-
dc.date.issued	2016	-
dc.identifier.issn	0195-6108	de_CH
dc.identifier.issn	1936-959X	de_CH
dc.identifier.uri	https://digitalcollection.zhaw.ch/handle/11475/11502	-
dc.description.abstract	Background and purpose: Normative age-related decline in paravertebral muscle quality is important for reference to disease and risk identification in patients. We aimed to establish age- and vertebral level–dependence of paravertebral (multifidus and erector spinae) muscle volume and fat content in healthy adult volunteers. Materials and Methods: In this prospective study multifidus and erector spinae fat signal fraction and volume at lumbar levels L1–L5 were measured in 80 healthy volunteers (10 women and men per decade, 20-62 years of age) by 2-point Dixon 3T MR imaging. ANOVA with post hoc Bonferroni correction compared fat signal fraction and volume among subgroups. Pearson and Spearman analysis were used for correlations (P < .05). Results: Fat signal fraction was higher in women (17.8% ± 10.7%) than men (14.7% ± 7.8%; P < .001) and increased with age. Multifidus and erector spinae volume was lower in women (565.4 ± 83.8 cm3) than in men (811.6 ± 98.9 cm3; P < .001) and was age-independent. No differences in fat signal fraction were shown between the right and left paravertebral muscles or among the L1, L2, and L3 lumbar levels. The fat signal fraction was highest at L5 (women, 31.9% ± 9.3%; men, 25.7% ± 8.0%; P < .001). The fat signal fraction at L4 correlated best with total lumbar fat signal fraction (women, r = 0.95; men, r = 0.92, P < .001). Total fat signal fraction was higher in the multifidus compared with erector spinae muscles at L1-L4 for both sexes (P < .001). Conclusions: Lumbar paravertebral muscle fat content increases with aging, independent of volume, in healthy volunteers 20-62 years of age. Women, low lumbar levels, and the multifidus muscle are most affected. Further study examining younger and older subjects and the functional impact of fatty infiltrated paravertebral muscles are warranted.	de_CH
dc.language.iso	en	de_CH
dc.publisher	American Society of Neuroradiology	de_CH
dc.relation.ispartof	American Journal of Neuroradiology	de_CH
dc.rights	Licence according to publishing contract	de_CH
dc.subject	Body Mass Index	de_CH
dc.subject	ElectriciImpedance	de_CH
dc.subject	Low back pain	de_CH
dc.subject	Lumbosacral region	de_CH
dc.subject	Magnetic Resonance Imaging	de_CH
dc.subject	Sex characteristics	de_CH
dc.subject.ddc	617.5: Orthopädische Chirurgie	de_CH
dc.title	Age- and level-dependence of fatty infiltration in lumbar paravertebral muscles of healthy volunteers	de_CH
dc.type	Beitrag in wissenschaftlicher Zeitschrift	de_CH
dcterms.type	Text	de_CH
zhaw.departement	Gesundheit	de_CH
zhaw.organisationalunit	Institut für Public Health (IPH)	de_CH
dc.identifier.doi	10.3174/ajnr.A4596	de_CH
dc.identifier.pmid	26635285	de_CH
zhaw.funding.eu	No	de_CH
zhaw.issue	4	de_CH
zhaw.originated.zhaw	Yes	de_CH
zhaw.pages.end	748	de_CH
zhaw.pages.start	742	de_CH
zhaw.publication.status	publishedVersion	de_CH
zhaw.volume	37	de_CH
zhaw.publication.review	Peer review (Publikation)	de_CH
Appears in collections:	Publikationen Gesundheit

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Crawford, R. J., Filli, L., Elliott, J. M., Nanz, D., Fischer, M. A., Marcon, M., & Ulbrich, E. J. (2016). Age- and level-dependence of fatty infiltration in lumbar paravertebral muscles of healthy volunteers. American Journal of Neuroradiology, 37(4), 742–748. https://doi.org/10.3174/ajnr.A4596

Crawford, R.J. et al. (2016) ‘Age- and level-dependence of fatty infiltration in lumbar paravertebral muscles of healthy volunteers’, American Journal of Neuroradiology, 37(4), pp. 742–748. Available at: https://doi.org/10.3174/ajnr.A4596.

R. J. Crawford et al., “Age- and level-dependence of fatty infiltration in lumbar paravertebral muscles of healthy volunteers,” American Journal of Neuroradiology, vol. 37, no. 4, pp. 742–748, 2016, doi: 10.3174/ajnr.A4596.

CRAWFORD, Rebecca J., L. FILLI, J.M. ELLIOTT, D. NANZ, M.A. FISCHER, M. MARCON und E.J. ULBRICH, 2016. Age- and level-dependence of fatty infiltration in lumbar paravertebral muscles of healthy volunteers. American Journal of Neuroradiology. 2016. Bd. 37, Nr. 4, S. 742–748. DOI 10.3174/ajnr.A4596

Crawford, Rebecca J., L. Filli, J.M. Elliott, D. Nanz, M.A. Fischer, M. Marcon, and E.J. Ulbrich. 2016. “Age- and Level-Dependence of Fatty Infiltration in Lumbar Paravertebral Muscles of Healthy Volunteers.” American Journal of Neuroradiology 37 (4): 742–48. https://doi.org/10.3174/ajnr.A4596.

Crawford, Rebecca J., et al. “Age- and Level-Dependence of Fatty Infiltration in Lumbar Paravertebral Muscles of Healthy Volunteers.” American Journal of Neuroradiology, vol. 37, no. 4, 2016, pp. 742–48, https://doi.org/10.3174/ajnr.A4596.