Publication type: Conference paper
Type of review: Peer review (publication)
Title: Clinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape
Authors: Hirsch, Sven
Egger, Julian
Wanke, Isabel
Kulcsar, Zsolt
Rüfenacht, Daniel
Proceedings: CMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineering
Page(s): 107
Pages to: 110
Conference details: CMBE 2013, Hong Kong, , 16-18 December 2013
Issue Date: 2013
Publisher / Ed. Institution: City University of Hong Kong
Publisher / Ed. Institution: Hong Kong
ISBN: 978-0-9562914-2-4
ISSN: 2227-3085
Language: English
Subjects: Biomedical simulation; Intracranial aneurysms; Blood flow; Thrombus; Remodeling; Endovascular treatment
Subject (DDC): 616: Internal medicine and diseases
Abstract: We present a clinical perspective, supported by biological findings, reflecting the potential of computational tools to understand and treat intracranial aneurysms. Thrombus formation and chronic inflammation are integral to disease progression, driven by blood flow energy. The interplay between flow energy, blood clotting and remodeling of the tissue is key to an enhanced disease understanding, to improve patient counseling and ultimately endovascular treatment planning. Current concepts suggest that blood governs wall remodeling by multiple biological steps. The process starts with flow induced thrombus adhesion (atherothrombosis) to the wall that secondarily leads to the release of biological mediators of inflammation entertaining destructive remodeling. Destructive wall remodeling jeopardizes the mechanical wall integrity with ensuing circumscribed softening and expansion of the aneurysm shape. The shape of an aneurysm is the visible result of these complex pathological processes and characterizes its disease status. Wall adherent thrombus formation, inflammatory reactions and the driving force of blood flow cause lumen shape changes. Here, shape irregularity is a distinctive sign of focal wall weakening. The integration of shape-analysis,vascular biology and phenotypical information will allow for personalized characterization of aneurysmal vascular disease and help to identify and establish shape as an image-based biomarker. Future translational efforts should aim at providing adequate IT tools and contributing to validation and disease understanding. Ensuing results will have a high likelihood to impact significantly on current clinical disease management.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Computational Life Sciences (ICLS)
Published as part of the ZHAW project: AneuX
Appears in collections:Publikationen Life Sciences und Facility Management

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