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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Industrial application of 2-oxoglutarate-dependent oxygenases
Authors: Peters, Christin
Buller, Rebecca
DOI: 10.21256/zhaw-2796
Published in: Catalysts
Volume(Issue): 9
Issue: 3
Page(s): 221
Pages to: 240
Issue Date: 2019
Publisher / Ed. Institution: MDPI
ISSN: 2073-4344
Language: German
Subject (DDC): 660.6: Biotechnology
Abstract: C-H functionalization is a chemically challenging but highly desirable transformation. 2-oxoglutarate-dependent oxygenases (2OGXs) are remarkably versatile biocatalysts for the activation of C-H bonds. In nature, they have been shown to accept both small and large molecules carrying out a plethora of reactions, including hydroxylations, demethylations, ring formations, rearrangements, desaturations, and halogenations, making them promising candidates for industrial manufacture. In this review, we describe the current status of 2OGX use in biocatalytic applications concentrating on 2OGX-catalyzed oxyfunctionalization of amino acids and synthesis of antibiotics. Looking forward, continued bioinformatic sourcing will help identify additional, practical useful members of this intriguing enzyme family, while enzyme engineering will pave the way to enhance 2OGX reactivity for non-native substrates.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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