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dc.contributor.authorGómez Real, Francisco-
dc.contributor.authorBurgess, John A.-
dc.contributor.authorVillani, Simona-
dc.contributor.authorDratva, Julia-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorJanson, Christer-
dc.contributor.authorJarvis, Debbie-
dc.contributor.authorKoplin, Jennifer-
dc.contributor.authorLeynaert, Bénédicte-
dc.contributor.authorLodge, Caroline-
dc.contributor.authorLærum, Birger N.-
dc.contributor.authorMatheson, Melanie C.-
dc.contributor.authorNorbäck, Dan-
dc.contributor.authorOmenaas, Ernst R.-
dc.contributor.authorSkulstad, Svein M.-
dc.contributor.authorSunyer, Jordi-
dc.contributor.authorDharmage, Shyamali C.-
dc.contributor.authorSvanes, Cecilie-
dc.date.accessioned2019-06-13T14:54:31Z-
dc.date.available2019-06-13T14:54:31Z-
dc.date.issued2018-
dc.identifier.issn0903-1936de_CH
dc.identifier.issn1399-3003de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/17251-
dc.description.abstractThere is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry.Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (ptrend 0.025) than in males (ptrend 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (pinteraction 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors.Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.de_CH
dc.language.isoende_CH
dc.publisherEuropean Respiratory Societyde_CH
dc.relation.ispartofThe European Respiratory Journalde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAdolescentde_CH
dc.subjectAdultde_CH
dc.subjectAsthmade_CH
dc.subjectFemalede_CH
dc.subjectForced expiratory volumede_CH
dc.subjectHealth surveyde_CH
dc.subjectHumande_CH
dc.subjectImmunoglobulin Ede_CH
dc.subjectInternationalityde_CH
dc.subjectLinear modelde_CH
dc.subjectLogistic modelde_CH
dc.subjectLungde_CH
dc.subjectMalede_CH
dc.subjectMiddle agedde_CH
dc.subjectPregnancyde_CH
dc.subjectPrenatal exposure delayed effectde_CH
dc.subjectSex factorde_CH
dc.subjectSmokingde_CH
dc.subjectYoung adultde_CH
dc.subjectMaternal agede_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleMaternal age at delivery, lung function and asthma in offspring : a population-based surveyde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Public Health (IPH)de_CH
dc.identifier.doi10.1183/13993003.01611-2016de_CH
dc.identifier.pmid29880541de_CH
zhaw.funding.euNode_CH
zhaw.issue1601611de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume51de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Gómez Real, F., Burgess, J. A., Villani, S., Dratva, J., Heinrich, J., Janson, C., Jarvis, D., Koplin, J., Leynaert, B., Lodge, C., Lærum, B. N., Matheson, M. C., Norbäck, D., Omenaas, E. R., Skulstad, S. M., Sunyer, J., Dharmage, S. C., & Svanes, C. (2018). Maternal age at delivery, lung function and asthma in offspring : a population-based survey. The European Respiratory Journal, 51(1601611). https://doi.org/10.1183/13993003.01611-2016
Gómez Real, F. et al. (2018) ‘Maternal age at delivery, lung function and asthma in offspring : a population-based survey’, The European Respiratory Journal, 51(1601611). Available at: https://doi.org/10.1183/13993003.01611-2016.
F. Gómez Real et al., “Maternal age at delivery, lung function and asthma in offspring : a population-based survey,” The European Respiratory Journal, vol. 51, no. 1601611, 2018, doi: 10.1183/13993003.01611-2016.
GÓMEZ REAL, Francisco, John A. BURGESS, Simona VILLANI, Julia DRATVA, Joachim HEINRICH, Christer JANSON, Debbie JARVIS, Jennifer KOPLIN, Bénédicte LEYNAERT, Caroline LODGE, Birger N. LÆRUM, Melanie C. MATHESON, Dan NORBÄCK, Ernst R. OMENAAS, Svein M. SKULSTAD, Jordi SUNYER, Shyamali C. DHARMAGE und Cecilie SVANES, 2018. Maternal age at delivery, lung function and asthma in offspring : a population-based survey. The European Respiratory Journal. 2018. Bd. 51, Nr. 1601611. DOI 10.1183/13993003.01611-2016
Gómez Real, Francisco, John A. Burgess, Simona Villani, Julia Dratva, Joachim Heinrich, Christer Janson, Debbie Jarvis, et al. 2018. “Maternal Age at Delivery, Lung Function and Asthma in Offspring : A Population-Based Survey.” The European Respiratory Journal 51 (1601611). https://doi.org/10.1183/13993003.01611-2016.
Gómez Real, Francisco, et al. “Maternal Age at Delivery, Lung Function and Asthma in Offspring : A Population-Based Survey.” The European Respiratory Journal, vol. 51, no. 1601611, 2018, https://doi.org/10.1183/13993003.01611-2016.


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