Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes

Wade-Bohleber, L.M.; Böker, H.; Grimm, S.; Gärtner, M.; Ernst, J.; Recher, D.A.; Buergi, N.; Seifritz, E.; Richter, A.

doi:10.1016/j.jad.2020.05.110

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-20307

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes
Authors:	Wade-Bohleber, L.M. Böker, H. Grimm, S. Gärtner, M. Ernst, J. Recher, D.A. Buergi, N. Seifritz, E. Richter, A.
et. al:	No
DOI:	10.1016/j.jad.2020.05.110 10.21256/zhaw-20307
Published in:	Journal of Affective Disorders
Volume(Issue):	274
Page(s):	522
Pages to:	534
Issue Date:	2020
Publisher / Ed. Institution:	Elsevier
ISSN:	0165-0327 1573-2517
Language:	English
Subjects:	Depression; Early adversity; Interpersonal functioning; Social cognition; Autobiographic memory retrieval; Task-based functional connectivity
Subject (DDC):	616.8: Neurology, diseases of nervous system
Abstract:	Background Depression and the experience of early adversity are associated with impairments in interpersonal and social cognitive functioning. The neural mechanisms involved in these impairments remain insufficiently understood. Methods In a sample of 48 depressed and 50 healthy participants, we explored seed-to-voxel functional connectivity (FC) during the recall of formative relationship episodes using functional magnetic resonance imaging. Results While depressive symptoms were associated with increased FC of brain regions that form an introspective socio-affective network, such as the precuneus, bilateral anterior insula, dorsal anterior cingulate cortex, left amygdala, and medial prefrontal cortex, early adversity linked to decreased FC of brain regions mediating emotion processing such as the bilateral anterior insula and increased FC of the bilateral parahippocampal gyrus. Limitations We report both results that are corrected for the number of seeds tested in FC analyses using strict Bonferroni adjustments and unadjusted results as part of an exploratory analysis. Discussion Our findings suggest that depression and early adversity are associated with differential FC patterns in the brain during the recall of formative relationship episodes. Hyperconnectivity of an introspective socio-affective network associated with depressive symptoms may link to enhanced self-focus and emotional reactivity. Patterns of neural activation associated with early adversity may underpin numbed affective states or enhanced affective memory regulation. Overall, these findings inform about the neural underpinnings of a reflective ability that is predictive of the adaptation to depression and to early adversity and relevant for psychotherapy outcomes.
URI:	https://digitalcollection.zhaw.ch/handle/11475/20307
Fulltext version:	Published version
License (according to publishing contract):	CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

Files in This Item:

File	Description	Size	Format
2020_Wade-Bohleber-etal_Depression-recall-formative-relationship-episodes_JAD.pdf		2.28 MB	Adobe PDF	View/Open

Show full item record

Wade-Bohleber, L. M., Böker, H., Grimm, S., Gärtner, M., Ernst, J., Recher, D. A., Buergi, N., Seifritz, E., & Richter, A. (2020). Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes. Journal of Affective Disorders, 274, 522–534. https://doi.org/10.1016/j.jad.2020.05.110

Wade-Bohleber, L.M. et al. (2020) ‘Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes’, Journal of Affective Disorders, 274, pp. 522–534. Available at: https://doi.org/10.1016/j.jad.2020.05.110.

L. M. Wade-Bohleber et al., “Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes,” Journal of Affective Disorders, vol. 274, pp. 522–534, 2020, doi: 10.1016/j.jad.2020.05.110.

WADE-BOHLEBER, L.M., H. BÖKER, S. GRIMM, M. GÄRTNER, J. ERNST, D.A. RECHER, N. BUERGI, E. SEIFRITZ und A. RICHTER, 2020. Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes. Journal of Affective Disorders. 2020. Bd. 274, S. 522–534. DOI 10.1016/j.jad.2020.05.110

Wade-Bohleber, L.M., H. Böker, S. Grimm, M. Gärtner, J. Ernst, D.A. Recher, N. Buergi, E. Seifritz, and A. Richter. 2020. “Depression Is Associated with Hyperconnectivity of an Introspective Socio-Affective Network during the Recall of Formative Relationship Episodes.” Journal of Affective Disorders 274: 522–34. https://doi.org/10.1016/j.jad.2020.05.110.

Wade-Bohleber, L. M., et al. “Depression Is Associated with Hyperconnectivity of an Introspective Socio-Affective Network during the Recall of Formative Relationship Episodes.” Journal of Affective Disorders, vol. 274, 2020, pp. 522–34, https://doi.org/10.1016/j.jad.2020.05.110.