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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-20351
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dc.contributor.authorPehlic, Vildana-
dc.contributor.authorVolken, Thomas-
dc.contributor.authorHolbro, Andreas-
dc.contributor.authorJirout, Zuzana-
dc.contributor.authorDrexler, Beatrice-
dc.contributor.authorBuser, Andreas-
dc.contributor.authorInfanti, Laura-
dc.date.accessioned2020-08-17T08:24:48Z-
dc.date.available2020-08-17T08:24:48Z-
dc.date.issued2020-08-05-
dc.identifier.issn1660-3796de_CH
dc.identifier.issn1660-3818de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/20351-
dc.description.abstractBackground: High-intensity donation is a risk factor for iron deficiency in blood donors. Interdonation intervals for whole blood (WB) donation and double unit red blood cell apheresis (2RBC) vary among countries. We retrospectively evaluated the course of haemoglobin (Hb) and ferritin values in men regularly donating WB 4 times a year or 2RBC twice a year (i.e., maximal frequency) over a period of 48 months. Methods: Data of male donors with 16 WB or 8 2RBC consecutive donations were analysed. The minimum Hb levels for WB donation and 2RBC apheresis (collection of 360 mL RBC) were 135 and 140 g/L, respectively. There was no lower limit set for ferritin, and no iron was substituted. Results: We identified 294 WB (mean age 53 years, SD 11) and 151 2RBC donors (mean age 48 years, SD 9) who donated at a mean interval of 97 (SD 18) and 201 days (SD 32), respectively, between January 1, 2008, and December 31, 2013. At baseline, Hb and ferritin values were lower in WB donors compared to 2RBC donors, with a mean Hb of 153 g/L (SD 13) versus 159 g/L (SD 8) and a mean ferritin of 44 μg/L (SD 52) versus 73 μg/L (SD 56; p < 0.001 for both parameters), respectively. Ferritin was below 15 μg/L in 40 WB (14%) and in 4 (3%) 2RBC donors. In WB donors, the mean Hb levels at baseline versus last donation showed no significant difference (153 vs. 152g/L, p = 0.068), whereas the mean ferritin levels decreased significantly (44 vs. 35 μg/L, p < 0.001). The 2RBC donor group displayed a statistically different decrease in both the mean Hb levels (158 vs. 157 g/L; p < 0.05) and the mean ferritin levels (73 vs. 66 μg/L; p = 0.052). The lowest Hb was measured at the 11th WB donation (152 g/L; p < 0.05) and at the 4th 2RBC apheresis (157 g/L; p < 0.05). There was no deferral due to low Hb at any time. The lowest ferritin was shown at the 4th WB (37 μg/L) and at the 3rd 2RBC donation (60 μg/L), respectively. At the last visit, ferritin was below 15 μg/L in 23 WB donors (8%) and in 2 2RBC donors (1%). Conclusions: High-intensity male donors with an interdonation interval of 12 weeks for WB donation and 24 weeks for 2RBC apheresis maintain acceptable Hb levels and, after an initial decline,stable ferritin levels despite ongoing blood donation.de_CH
dc.language.isoende_CH
dc.publisherKargerde_CH
dc.relation.ispartofTransfusion Medicine and Hemotherapyde_CH
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/de_CH
dc.subjectHigh-frequency donorsde_CH
dc.subjectInterdonation intervalde_CH
dc.subjectFerritinde_CH
dc.subjectHaemoglobinde_CH
dc.subject.ddc610: Medizin und Gesundheitde_CH
dc.titleLong-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresisde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Public Health (IPH)de_CH
dc.identifier.doi10.1159/000509026de_CH
dc.identifier.doi10.21256/zhaw-20351-
zhaw.funding.euNode_CH
zhaw.issue2de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end78de_CH
zhaw.pages.start71de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume48de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Pehlic, V., Volken, T., Holbro, A., Jirout, Z., Drexler, B., Buser, A., & Infanti, L. (2020). Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis. Transfusion Medicine and Hemotherapy, 48(2), 71–78. https://doi.org/10.1159/000509026
Pehlic, V. et al. (2020) ‘Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis’, Transfusion Medicine and Hemotherapy, 48(2), pp. 71–78. Available at: https://doi.org/10.1159/000509026.
V. Pehlic et al., “Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis,” Transfusion Medicine and Hemotherapy, vol. 48, no. 2, pp. 71–78, Aug. 2020, doi: 10.1159/000509026.
PEHLIC, Vildana, Thomas VOLKEN, Andreas HOLBRO, Zuzana JIROUT, Beatrice DREXLER, Andreas BUSER und Laura INFANTI, 2020. Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis. Transfusion Medicine and Hemotherapy. 5 August 2020. Bd. 48, Nr. 2, S. 71–78. DOI 10.1159/000509026
Pehlic, Vildana, Thomas Volken, Andreas Holbro, Zuzana Jirout, Beatrice Drexler, Andreas Buser, and Laura Infanti. 2020. “Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis.” Transfusion Medicine and Hemotherapy 48 (2): 71–78. https://doi.org/10.1159/000509026.
Pehlic, Vildana, et al. “Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis.” Transfusion Medicine and Hemotherapy, vol. 48, no. 2, Aug. 2020, pp. 71–78, https://doi.org/10.1159/000509026.


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