| Publication type: | Book part |
| Type of review: | Editorial review |
| Title: | Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents |
| Authors: | Eibl-Schindler, Regine Eibl, Dieter |
| DOI: | 10.1007/10_2008_23 |
| Published in: | Bioreactor systems for tissue engineering |
| Editors of the parent work: | Kasper, Cornelia van Griensven, Martijn Pörtner, Ralf |
| Page(s): | 183 |
| Pages to: | 207 |
| Issue Date: | 2009 |
| Series: | Advances in Biochemical Engineering/Biotechnology |
| Series volume: | 112 |
| Publisher / Ed. Institution: | Springer |
| Publisher / Ed. Institution: | Berlin |
| ISBN: | 978-3-540-69356-7 978-3-540-69357-4 |
| Language: | English |
| Subjects: | Keywords Cell expansion; Disposable bag bioreactor; Functional tissue; Stem cells; Therapeutic agents |
| Subject (DDC): | 610: Medicine and health 660: Chemical engineering |
| Abstract: | In order to increase process efficiency, many pharmaceutical and biotechnology companies have introduced disposable bag technology over the last 10 years. Because this technology also greatly reduces the risk of cross-contamination, disposable bags are preferred in applications in which an absolute or improved process safety is a necessity, namely the production of functional tissue for implantation (tissue engineering), the production of human cells for the treatment of cancer and immune system diseases (cellular therapy), the production of viruses for gene therapies, the production of therapeutic proteins, and veterinary as well as human vaccines. Bioreactors with a pre-sterile cultivation bag made of plastic material are currently used in both development and manufacturing processes primarily operating with animal and human cells at small- and middle-volume scale. Because of their scalability, hydrodynamic expertise and the convincing results of oxygen transport efficiency studies, wave-mixed bioreactors are the most used, together with stirred bag bioreactors and static bags, which have the longest tradition. Starting with a general overview of disposable bag bioreactors and their main applications, this chapter summarizes the working principles and engineering aspects of bag bioreactors suitable for cell expansion, formation of functional tissue and production of therapeutic agents. Furthermore, results from selected cultivation studies are presented and discussed. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2269 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Eibl-Schindler, R., & Eibl, D. (2009). Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents. In C. Kasper, M. van Griensven, & R. Pörtner (Eds.), Bioreactor systems for tissue engineering (pp. 183–207). Springer. https://doi.org/10.1007/10_2008_23
Eibl-Schindler, R. and Eibl, D. (2009) ‘Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents’, in C. Kasper, M. van Griensven, and R. Pörtner (eds) Bioreactor systems for tissue engineering. Berlin: Springer, pp. 183–207. Available at: https://doi.org/10.1007/10_2008_23.
R. Eibl-Schindler and D. Eibl, “Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents,” in Bioreactor systems for tissue engineering, C. Kasper, M. van Griensven, and R. Pörtner, Eds. Berlin: Springer, 2009, pp. 183–207. doi: 10.1007/10_2008_23.
EIBL-SCHINDLER, Regine und Dieter EIBL, 2009. Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents. In: Cornelia KASPER, Martijn VAN GRIENSVEN und Ralf PÖRTNER (Hrsg.), Bioreactor systems for tissue engineering. Berlin: Springer. S. 183–207. ISBN 978-3-540-69356-7
Eibl-Schindler, Regine, and Dieter Eibl. 2009. “Application of Disposable Bag-Bioreactors in Tissue Engineering and for Production of Therapeutic Agents.” In Bioreactor Systems for Tissue Engineering, edited by Cornelia Kasper, Martijn van Griensven, and Ralf Pörtner, 183–207. Berlin: Springer. https://doi.org/10.1007/10_2008_23.
Eibl-Schindler, Regine, and Dieter Eibl. “Application of Disposable Bag-Bioreactors in Tissue Engineering and for Production of Therapeutic Agents.” Bioreactor Systems for Tissue Engineering, edited by Cornelia Kasper et al., Springer, 2009, pp. 183–207, https://doi.org/10.1007/10_2008_23.
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