Continuous milli-scale reaction calorimeter for direct scale-up of flow chemistry

Moser, Marlies; Georg, Alain G.; Steinemann, Finn Lorenz; Meier, Daniel Matthias; Rütti, David

doi:10.1007/s41981-021-00204-y

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-23441

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Continuous milli-scale reaction calorimeter for direct scale-up of flow chemistry
Authors:	Moser, Marlies Georg, Alain G. Steinemann, Finn Lorenz Meier, Daniel Matthias Rütti, David
et. al:	No
DOI:	10.1007/s41981-021-00204-y 10.21256/zhaw-23441
Published in:	Journal of Flow Chemistry
Volume(Issue):	11
Issue:	3
Page(s):	691
Pages to:	699
Issue Date:	18-Oct-2021
Publisher / Ed. Institution:	Springer
ISSN:	2062-249X 2063-0212
Language:	English
Subjects:	Continuous fow reactor; Isoperibolic reaction calorimetry; Heat of reaction; Safety; Process development; Scale-up
Subject (DDC):	540: Chemistry
Abstract:	Reaction calorimetry of flow processes is important for scale-up and safety in flow chemistry. Due to the increasing number of flow processes, corresponding flow calorimeters are required as an alternative or addition to high-precision batch calorimeters. In this work, a milli-scale isoperibol continuous flow calorimeter was used to measure the heat of reaction based on an elaborated heat transfer model. This allows for reaction calorimetry without calibration. The model was tested with a selective, fast and exothermic neutralization reaction of acetic acid and sodium hydroxide at different flow rates, concentrations and viscosities. Deviations of the mean heats of reaction from the literature values were only about 2%. The calorimetric data can further be used for direct scale-up with tube bundle mixer heat exchangers having similar heat transfer characteristics. In addition, a reaction screening at different flow rates allows to find the maximum temperature and maximum heat generation. This data is useful in safety analyses of continuous processes. For these reasons, continuous reaction calorimetry provides a practical scale-up tool for flow processes.
URI:	https://digitalcollection.zhaw.ch/handle/11475/23441
Fulltext version:	Accepted version
License (according to publishing contract):	Licence according to publishing contract
Restricted until:	2022-10-18
Departement:	School of Engineering
Organisational Unit:	Institute of Materials and Process Engineering (IMPE)
Published as part of the ZHAW project:	Entwicklung eines experimentbasierten Designtools für kontinuierliche Reaktoren
Appears in collections:	Publikationen School of Engineering

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Moser, M., Georg, A. G., Steinemann, F. L., Meier, D. M., & Rütti, D. (2021). Continuous milli-scale reaction calorimeter for direct scale-up of flow chemistry. Journal of Flow Chemistry, 11(3), 691–699. https://doi.org/10.1007/s41981-021-00204-y

Moser, M. et al. (2021) ‘Continuous milli-scale reaction calorimeter for direct scale-up of flow chemistry’, Journal of Flow Chemistry, 11(3), pp. 691–699. Available at: https://doi.org/10.1007/s41981-021-00204-y.

M. Moser, A. G. Georg, F. L. Steinemann, D. M. Meier, and D. Rütti, “Continuous milli-scale reaction calorimeter for direct scale-up of flow chemistry,” Journal of Flow Chemistry, vol. 11, no. 3, pp. 691–699, Oct. 2021, doi: 10.1007/s41981-021-00204-y.

MOSER, Marlies, Alain G. GEORG, Finn Lorenz STEINEMANN, Daniel Matthias MEIER und David RÜTTI, 2021. Continuous milli-scale reaction calorimeter for direct scale-up of flow chemistry. Journal of Flow Chemistry. 18 Oktober 2021. Bd. 11, Nr. 3, S. 691–699. DOI 10.1007/s41981-021-00204-y

Moser, Marlies, Alain G. Georg, Finn Lorenz Steinemann, Daniel Matthias Meier, and David Rütti. 2021. “Continuous Milli-Scale Reaction Calorimeter for Direct Scale-up of Flow Chemistry.” Journal of Flow Chemistry 11 (3): 691–99. https://doi.org/10.1007/s41981-021-00204-y.

Moser, Marlies, et al. “Continuous Milli-Scale Reaction Calorimeter for Direct Scale-up of Flow Chemistry.” Journal of Flow Chemistry, vol. 11, no. 3, Oct. 2021, pp. 691–99, https://doi.org/10.1007/s41981-021-00204-y.