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dc.contributor.authorGloor, S.-
dc.contributor.authorMisirlic, M.-
dc.contributor.authorFrei-Lanter, C.-
dc.contributor.authorHerzog, P.-
dc.contributor.authorMüller, P.-
dc.contributor.authorSchäfli-Thurnherr, J.-
dc.contributor.authorSchregel, D.-
dc.contributor.authorLamdark, T.-
dc.contributor.authorWyss, R.-
dc.contributor.authorUnger, I.-
dc.contributor.authorGisi, D.-
dc.contributor.authorGreco, N.-
dc.contributor.authorMungo, G.-
dc.contributor.authorWirz, M.-
dc.contributor.authorRaptis, D.A.-
dc.contributor.authorTschuor, C.-
dc.contributor.authorBreitenstein, S.-
dc.date.accessioned2022-02-25T12:27:36Z-
dc.date.available2022-02-25T12:27:36Z-
dc.date.issued2021-05-
dc.identifier.issn0007-1323de_CH
dc.identifier.issn1365-2168de_CH
dc.identifier.urihttps://academic.oup.com/bjs/article/108/Supplement_4/znab202.015/6287411de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/24270-
dc.description.abstractObjective: Patients undergoing major surgery are prone to a functional decline due to the impairment of muscle, cardiorespiratory and neurological function as a response to surgical stress. Currently, there are solely weak recommendations in the ERAS protocol regarding the role of preoperative physical activity and prehabilitation in patients undergoing colorectal surgery. Studies in heterogenous cohorts showed contradictory results regarding the impact of prehabilitation on the reduction of postoperative complications. This randomized controlled trial assesses the impact of prehabilitation on postoperative complications in patients undergoing colorectal surgery within an ERAS protocol. Methods: Between July 2016 and June 2019, a single-center, single-blinded , randomized controlled trial designed to test whether physiotherapeutic prehabilitation vs. normal physical activities prior to colorectal surgery may decrease morbidity within a stringent ERAS protocol was carried out. The primary endpoint was postoperative complications assessed by Comprehensive Complications Index (CCI®). Primary and secondary endpoints for both groups were analyzed and compared. Results: A total of 107 patients (54 in the pERACS and 53 in the control cohort) were included in the study and randomized. Dropout rate was 4.5% (n = 5). Mean age (SD) in the control cohort was 65 (29–86) and 66 (24–90) years in pERACS cohort. The pERACS cohort contained more female patients (40% vs. 55%, p = 0.123) and a higher percentage of colorectal adenocarcinoma (32% vs. 23%, p = 0.384) although not significant. Almost all patients underwent minimally invasive surgery in both cohorts (96% vs 98%, p = 1.000). There was no between-cohort difference in the primary outcome measure 30-day Comprehensive Complications Index (15 [0 – 49] vs. 18 [0 – 43], p = 0.059). Secondary outcome as complications assessed according to Clavien-Dindo, length of hospital stay, reoperation rate and mortality showed no difference between both cohorts. Conclusion: Routine physiotherapeutic prehabilitation cannot be recommended for patients undergoing colorectal surgery within an ERAS protocol (Grade A recommendation). To eliminate other confounders like geographical difference or difference in surgical technique, further multicenter RCTs are needed.de_CH
dc.language.isoende_CH
dc.publisherOxford University Pressde_CH
dc.relation.ispartofBritish Journal of Surgeryde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectPhysical activityde_CH
dc.subjectPhysiotherapyde_CH
dc.subjectColorectal surgeryde_CH
dc.subjectPreoperative carede_CH
dc.subject.ddc615.82: Physiotherapiede_CH
dc.subject.ddc617: Chirurgiede_CH
dc.titlePrehabilitation in patients undergoing colorectal surgery fails to confer reduction in overall morbidity : results of a single-center, single-blinded, randomized controlled trialde_CH
dc.typeKonferenz: Sonstigesde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Physiotherapie (IPT)de_CH
dc.identifier.doi10.1093/bjs/znab202.015de_CH
zhaw.conference.details108th Annual Swiss Congress of Surgery, virtual, 1-3 June 2021de_CH
zhaw.funding.euNode_CH
zhaw.issueSupplement 4de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume108de_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
zhaw.title.proceedingsAbstracts of the 108th Annual Swiss Congress of Surgery held as a virtual meeting 1-3 June 2021de_CH
zhaw.webfeedG: IPT: Interventionde_CH
zhaw.funding.zhawPräoperative Physiotherapie bei kolorektalen Eingriffende_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Gloor, S., Misirlic, M., Frei-Lanter, C., Herzog, P., Müller, P., Schäfli-Thurnherr, J., Schregel, D., Lamdark, T., Wyss, R., Unger, I., Gisi, D., Greco, N., Mungo, G., Wirz, M., Raptis, D. A., Tschuor, C., & Breitenstein, S. (2021). Prehabilitation in patients undergoing colorectal surgery fails to confer reduction in overall morbidity : results of a single-center, single-blinded, randomized controlled trial [Conference presentation]. British Journal of Surgery, 108(Supplement 4). https://doi.org/10.1093/bjs/znab202.015
Gloor, S. et al. (2021) ‘Prehabilitation in patients undergoing colorectal surgery fails to confer reduction in overall morbidity : results of a single-center, single-blinded, randomized controlled trial’, in British Journal of Surgery. Oxford University Press. Available at: https://doi.org/10.1093/bjs/znab202.015.
S. Gloor et al., “Prehabilitation in patients undergoing colorectal surgery fails to confer reduction in overall morbidity : results of a single-center, single-blinded, randomized controlled trial,” in British Journal of Surgery, May 2021, vol. 108, no. Supplement 4. doi: 10.1093/bjs/znab202.015.
GLOOR, S., M. MISIRLIC, C. FREI-LANTER, P. HERZOG, P. MÜLLER, J. SCHÄFLI-THURNHERR, D. SCHREGEL, T. LAMDARK, R. WYSS, I. UNGER, D. GISI, N. GRECO, G. MUNGO, M. WIRZ, D.A. RAPTIS, C. TSCHUOR und S. BREITENSTEIN, 2021. Prehabilitation in patients undergoing colorectal surgery fails to confer reduction in overall morbidity : results of a single-center, single-blinded, randomized controlled trial. In: British Journal of Surgery [online]. Conference presentation. Oxford University Press. Mai 2021. Verfügbar unter: https://academic.oup.com/bjs/article/108/Supplement_4/znab202.015/6287411
Gloor, S., M. Misirlic, C. Frei-Lanter, P. Herzog, P. Müller, J. Schäfli-Thurnherr, D. Schregel, et al. 2021. “Prehabilitation in Patients Undergoing Colorectal Surgery Fails to Confer Reduction in Overall Morbidity : Results of a Single-Center, Single-Blinded, Randomized Controlled Trial.” Conference presentation. In British Journal of Surgery. Vol. 108. Oxford University Press. https://doi.org/10.1093/bjs/znab202.015.
Gloor, S., et al. “Prehabilitation in Patients Undergoing Colorectal Surgery Fails to Confer Reduction in Overall Morbidity : Results of a Single-Center, Single-Blinded, Randomized Controlled Trial.” British Journal of Surgery, vol. 108, no. Supplement 4, Oxford University Press, 2021, https://doi.org/10.1093/bjs/znab202.015.


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