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  2. School of Engineering
  3. Publikationen
  4. Publikationen School of Engineering
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dc.contributor.authorKirsch, Christoph-
dc.contributor.authorFehr, Daniel-
dc.contributor.authorBabity, Samuel-
dc.contributor.authorPolomska, Anna-
dc.contributor.authorDetmar, Michael-
dc.contributor.authorBonmarin, Mathias-
dc.contributor.authorBrambilla, Davide-
dc.date.accessioned2022-03-04T12:59:25Z-
dc.date.available2022-03-04T12:59:25Z-
dc.date.issued2022-
dc.identifier.issn2190-393Xde_CH
dc.identifier.issn2190-3948de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/24468-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractThe quantitative assessment of lymphatic dermal clearance using NIR fluorescent tracers is particularly important for the early diagnosis of several potential disabling diseases. Currently, half-life values are computed using a mono-exponential mathematical model, neglecting diffusion of the tracer within the dermis after injection. The size and position of the region of interest are subjectively manually selected around the point of injection on the skin surface where the fluorescence signal intensity is averaged, neglecting any spatial information contained in the image. In this study we present and test a novel mathematical model allowing the objective quantification of dermal clearance, taking into consideration potential dermal diffusion. With only two parameters, this “clearance-diffusion” model is simple enough to be applied in a variety of settings and requires almost no prior information about the system. We demonstrate that if dermal diffusion is low, the mono-exponential approach is suitable but still lacking objectivity. However, if dermal diffusion is substantial, the clearance-diffusion model is superior and allows the accurate calculation of half-life values.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofDrug Delivery and Translational Researchde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectLymphatic drainagede_CH
dc.subjectFluorescencede_CH
dc.subjectDiffusionde_CH
dc.subjectIntradermal administrationde_CH
dc.subject.ddc510: Mathematikde_CH
dc.titleDevelopment of a diffusion-weighed mathematical model for intradermal drainage quantificationde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitute of Computational Physics (ICP)de_CH
dc.identifier.doi10.1007/s13346-021-01114-1de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end905de_CH
zhaw.pages.start897de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume12de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedSensors and Measuring Systemsde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Kirsch, C., Fehr, D., Babity, S., Polomska, A., Detmar, M., Bonmarin, M., & Brambilla, D. (2022). Development of a diffusion-weighed mathematical model for intradermal drainage quantification. Drug Delivery and Translational Research, 12(4), 897–905. https://doi.org/10.1007/s13346-021-01114-1
Kirsch, C. et al. (2022) ‘Development of a diffusion-weighed mathematical model for intradermal drainage quantification’, Drug Delivery and Translational Research, 12(4), pp. 897–905. Available at: https://doi.org/10.1007/s13346-021-01114-1.
C. Kirsch et al., “Development of a diffusion-weighed mathematical model for intradermal drainage quantification,” Drug Delivery and Translational Research, vol. 12, no. 4, pp. 897–905, 2022, doi: 10.1007/s13346-021-01114-1.
KIRSCH, Christoph, Daniel FEHR, Samuel BABITY, Anna POLOMSKA, Michael DETMAR, Mathias BONMARIN und Davide BRAMBILLA, 2022. Development of a diffusion-weighed mathematical model for intradermal drainage quantification. Drug Delivery and Translational Research. 2022. Bd. 12, Nr. 4, S. 897–905. DOI 10.1007/s13346-021-01114-1
Kirsch, Christoph, Daniel Fehr, Samuel Babity, Anna Polomska, Michael Detmar, Mathias Bonmarin, and Davide Brambilla. 2022. “Development of a Diffusion-Weighed Mathematical Model for Intradermal Drainage Quantification.” Drug Delivery and Translational Research 12 (4): 897–905. https://doi.org/10.1007/s13346-021-01114-1.
Kirsch, Christoph, et al. “Development of a Diffusion-Weighed Mathematical Model for Intradermal Drainage Quantification.” Drug Delivery and Translational Research, vol. 12, no. 4, 2022, pp. 897–905, https://doi.org/10.1007/s13346-021-01114-1.


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