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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-25480
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dc.contributor.authorDelaval, Mathilde N.-
dc.contributor.authorJonsdottir, Hulda R.-
dc.contributor.authorLeni, Zaira-
dc.contributor.authorKeller, Alejandro-
dc.contributor.authorBrem, Benjamin T.-
dc.contributor.authorSiegerist, Frithjof-
dc.contributor.authorSchönenberger, David-
dc.contributor.authorDurdina, Lukas-
dc.contributor.authorElser, Miriam-
dc.contributor.authorSalathe, Matthias-
dc.contributor.authorBaumlin, Nathalie-
dc.contributor.authorLobo, Prem-
dc.contributor.authorBurtscher, Heinz-
dc.contributor.authorLiati, Anthi-
dc.contributor.authorGeiser, Marianne-
dc.date.accessioned2022-08-19T14:19:52Z-
dc.date.available2022-08-19T14:19:52Z-
dc.date.issued2022-
dc.identifier.issn0269-7491de_CH
dc.identifier.issn1873-6424de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/25480-
dc.description.abstractHealth effects of particulate matter (PM) from aircraft engines have not been adequately studied since controlled laboratory studies reflecting realistic conditions regarding aerosols, target tissue, particle exposure and deposited particle dose are logistically challenging. Due to the important contributions of aircraft engine emissions to air pollution, we employed a unique experimental setup to deposit exhaust particles directly from an aircraft engine onto reconstituted human bronchial epithelia (HBE) at air-liquid interface under conditions similar to in vivo airways to mimic realistic human exposure. The toxicity of non-volatile PM (nvPM) from a CFM56-7B26 aircraft engine was evaluated under realistic engine conditions by sampling and exposing HBE derived from donors of normal and compromised health status to exhaust for 1 h followed by biomarker analysis 24 h post exposure. Particle deposition varied depending on the engine thrust levels with 85% thrust producing the highest nvPM mass and number emissions with estimated surface deposition of 3.17 × 109 particles cm-2 or 337.1 ng cm-2. Transient increase in cytotoxicity was observed after exposure to nvPM in epithelia derived from a normal donor as well as a decrease in the secretion of interleukin 6 and monocyte chemotactic protein 1. Non-replicated multiple exposures of epithelia derived from a normal donor to nvPM primarily led to a pro-inflammatory response, while both cytotoxicity and oxidative stress induction remained unaffected. This raises concerns for the long-term implications of aircraft nvPM for human pulmonary health, especially in occupational settings.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofEnvironmental Pollutionde_CH
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/de_CH
dc.subjectAerosolde_CH
dc.subjectAircraft engine exhaustde_CH
dc.subjectBronchial epithelial cell culturede_CH
dc.subjectCellular responsede_CH
dc.subjectNon-volatile particulate matterde_CH
dc.subjectAircraftde_CH
dc.subjectHumande_CH
dc.subjectParticulate matterde_CH
dc.subjectVehicle emissionde_CH
dc.subjectAir pollutantde_CH
dc.subjectAir pollutionde_CH
dc.subject.ddc363: Umwelt- und Sicherheitsproblemede_CH
dc.subject.ddc629: Luftfahrt- und Fahrzeugtechnikde_CH
dc.titleResponses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan enginede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitZentrum für Aviatik (ZAV)de_CH
dc.identifier.doi10.1016/j.envpol.2022.119521de_CH
dc.identifier.doi10.21256/zhaw-25480-
dc.identifier.pmid35623573de_CH
zhaw.funding.euNode_CH
zhaw.issue119521de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume307de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMeteorology, Environment and Air Traffic (ZAV)de_CH
zhaw.funding.zhawAGEAIR II: Vermessung der Gas- und Partikelschadstoffemissionen von Mantelstrom- und Helikoptertriebwerken sowie Abschätzung des Effektes vom Triebwerkverschleiss auf die Emissionsqualitätde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Delaval, M. N., Jonsdottir, H. R., Leni, Z., Keller, A., Brem, B. T., Siegerist, F., Schönenberger, D., Durdina, L., Elser, M., Salathe, M., Baumlin, N., Lobo, P., Burtscher, H., Liati, A., & Geiser, M. (2022). Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine. Environmental Pollution, 307(119521). https://doi.org/10.1016/j.envpol.2022.119521
Delaval, M.N. et al. (2022) ‘Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine’, Environmental Pollution, 307(119521). Available at: https://doi.org/10.1016/j.envpol.2022.119521.
M. N. Delaval et al., “Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine,” Environmental Pollution, vol. 307, no. 119521, 2022, doi: 10.1016/j.envpol.2022.119521.
DELAVAL, Mathilde N., Hulda R. JONSDOTTIR, Zaira LENI, Alejandro KELLER, Benjamin T. BREM, Frithjof SIEGERIST, David SCHÖNENBERGER, Lukas DURDINA, Miriam ELSER, Matthias SALATHE, Nathalie BAUMLIN, Prem LOBO, Heinz BURTSCHER, Anthi LIATI und Marianne GEISER, 2022. Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine. Environmental Pollution. 2022. Bd. 307, Nr. 119521. DOI 10.1016/j.envpol.2022.119521
Delaval, Mathilde N., Hulda R. Jonsdottir, Zaira Leni, Alejandro Keller, Benjamin T. Brem, Frithjof Siegerist, David Schönenberger, et al. 2022. “Responses of Reconstituted Human Bronchial Epithelia from Normal and Health-Compromised Donors to Non-Volatile Particulate Matter Emissions from an Aircraft Turbofan Engine.” Environmental Pollution 307 (119521). https://doi.org/10.1016/j.envpol.2022.119521.
Delaval, Mathilde N., et al. “Responses of Reconstituted Human Bronchial Epithelia from Normal and Health-Compromised Donors to Non-Volatile Particulate Matter Emissions from an Aircraft Turbofan Engine.” Environmental Pollution, vol. 307, no. 119521, 2022, https://doi.org/10.1016/j.envpol.2022.119521.


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