Evolution of tibial SSEP after traumatic spinal cord injury: baseline for clinical trials

Spiess, Martina; Schubert, Martin; Kliesch, Uta; Halder, Pascal

doi:10.1016/j.clinph.2008.01.021

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Evolution of tibial SSEP after traumatic spinal cord injury: baseline for clinical trials
Authors:	Spiess, Martina Schubert, Martin Kliesch, Uta Halder, Pascal
et. al:	No
DOI:	10.1016/j.clinph.2008.01.021
Published in:	Clinical Neurophysiology
Volume(Issue):	119
Issue:	5
Page(s):	1051
Pages to:	1061
Issue Date:	May-2008
Publisher / Ed. Institution:	Elsevier
ISSN:	1388-2457 1872-8952
Language:	English
Subjects:	Adult; Evoked Potential, somatosensory; Female; Humans; Longitudinal Study; Male; Middle aged; Recovery of function; Spinal Cord injury; Tibial Nerve; Time
Subject (DDC):	616.8: Neurology, diseases of nervous system 617: Surgery
Abstract:	Objective: To describe the spontaneous evolution of tibial somatosensory evoked potentials (tSSEPs) after spinal cord injury (SCI) and its relation to neurological and functional parameters. Methods: tSSEPs were assessed in 297 patients within five standardized time intervals throughout the first year after injury, along with neurological and functional parameters. Results: Roughly 60% of the patients did not show any recordable tSSEP throughout the first year after injury. Approximately 20% had recordable potentials at every assessment stage and showed an improvement of tSSEP parameters over time. In about 10% of the patients, a potential recovered during the first year. In the remaining cases, potentials were inconsistently recordable. All groups showed a similar amount of neurological and functional improvement. Conclusions: Recordability, latencies and amplitudes of tSSEPs can change over time after SCI. The early recordability of a tSSEP is associated with a favorable functional and neurological status and outcome. In contrast, an initially absent tSSEP is not always associated with a poorer status and outcome but only in those 75% of the patients in whom the potential remains absent. Significance: This exact description of the spontaneous improvements of neurophysiological, neurological and functional parameters after SCI is an important prerequisite in appraising the efficacy of new interventional therapies.
URI:	https://digitalcollection.zhaw.ch/handle/11475/25607
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Occupational Therapy (IER)
Appears in collections:	Publikationen Gesundheit

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Spiess, M., Schubert, M., Kliesch, U., & Halder, P. (2008). Evolution of tibial SSEP after traumatic spinal cord injury: baseline for clinical trials. Clinical Neurophysiology, 119(5), 1051–1061. https://doi.org/10.1016/j.clinph.2008.01.021

Spiess, M. et al. (2008) ‘Evolution of tibial SSEP after traumatic spinal cord injury: baseline for clinical trials’, Clinical Neurophysiology, 119(5), pp. 1051–1061. Available at: https://doi.org/10.1016/j.clinph.2008.01.021.

M. Spiess, M. Schubert, U. Kliesch, and P. Halder, “Evolution of tibial SSEP after traumatic spinal cord injury: baseline for clinical trials,” Clinical Neurophysiology, vol. 119, no. 5, pp. 1051–1061, May 2008, doi: 10.1016/j.clinph.2008.01.021.

SPIESS, Martina, Martin SCHUBERT, Uta KLIESCH und Pascal HALDER, 2008. Evolution of tibial SSEP after traumatic spinal cord injury: baseline for clinical trials. Clinical Neurophysiology. Mai 2008. Bd. 119, Nr. 5, S. 1051–1061. DOI 10.1016/j.clinph.2008.01.021

Spiess, Martina, Martin Schubert, Uta Kliesch, and Pascal Halder. 2008. “Evolution of Tibial SSEP after Traumatic Spinal Cord Injury: Baseline for Clinical Trials.” Clinical Neurophysiology 119 (5): 1051–61. https://doi.org/10.1016/j.clinph.2008.01.021.

Spiess, Martina, et al. “Evolution of Tibial SSEP after Traumatic Spinal Cord Injury: Baseline for Clinical Trials.” Clinical Neurophysiology, vol. 119, no. 5, May 2008, pp. 1051–61, https://doi.org/10.1016/j.clinph.2008.01.021.