Development of Yb2O3-based ceramics for indirect production of 177Lu used in targeted radionuclide therapies

Gorbar, Michal; Mauchle, Stéphane; Aebi, Patric; Bitterli, Beat; Penner, Dirk

Publication type:	Conference other
Type of review:	Peer review (abstract)
Title:	Development of Yb2O3-based ceramics for indirect production of 177Lu used in targeted radionuclide therapies
Authors:	Gorbar, Michal Mauchle, Stéphane Aebi, Patric Bitterli, Beat Penner, Dirk
et. al:	No
Conference details:	Ceramics in Europe, Kraków, Poland, 10-14 July 2022
Issue Date:	Jul-2022
Language:	English
Subject (DDC):	615: Pharmacology and therapeutics 620.11: Engineering materials
Abstract:	The demand for targeted radionuclide therapies (TRT) increases worldwide with surging numbers of cancerogenic cases. There is a growing concern that the availability of such medical isotopes may not be sufficient in the long term. In particular, the 177Lu is identified as an important example of a medical isotope to be at risk for future shortages. The challenges of its production routes, as well as the limited accessibility to nuclear research facilities need to be therefore addressed and debated. In this work we discuss the distinctive aspects of forming ceramic targets based on Yb2O3, as this material possesses sufficient chemical and thermal stability under reactor irradiation to obtain the 177Lu radionuclide. The study comprises the Yb2O3 powder to be initially doped with aluminum isopropoxide prior to formation of cylinders with diameter below 1.7 mm. Consequently, the grain-growth and creation of a new phase Yb4Al2O9/ Yb3Al5O12 between formed Al2O3 and Yb2O3 during sintering at 1750 °C in air atmosphere improves the densification and leads to increase of Vicker’s hardness and mechanical stability of such manufactured targets. The stability of Al2O3-doped Yb2O3 targets is tested via impact test through 12 meters long steel tube having two arc points, while the system is pressurized with N2 gas up to 10 bar. Twenty-five specimens are shot through the pipe to simulate the activation route as in the nuclear reactor with 100 % success rate of such an impact test. The post processing of the solid material takes place in autoclaved system at 260 °C, 40 bar and acidic mixture of H2O/HCl/HNO3 until the complete dissolution is achieved, usually no longer than 26 minutes. Thus, allowing the newly created radionuclide to be extracted and further used for medical purposes.
URI:	https://digitalcollection.zhaw.ch/handle/11475/25812
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Engineering
Organisational Unit:	Institute of Materials and Process Engineering (IMPE)
Published as part of the ZHAW project:	Keramiktargets für die Radionuklidtherapie
Appears in collections:	Publikationen School of Engineering

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Gorbar, M., Mauchle, S., Aebi, P., Bitterli, B., & Penner, D. (2022, July). Development of Yb2O3-based ceramics for indirect production of 177Lu used in targeted radionuclide therapies. Ceramics in Europe, Kraków, Poland, 10-14 July 2022.

Gorbar, M. et al. (2022) ‘Development of Yb2O3-based ceramics for indirect production of 177Lu used in targeted radionuclide therapies’, in Ceramics in Europe, Kraków, Poland, 10-14 July 2022.

M. Gorbar, S. Mauchle, P. Aebi, B. Bitterli, and D. Penner, “Development of Yb2O3-based ceramics for indirect production of 177Lu used in targeted radionuclide therapies,” in Ceramics in Europe, Kraków, Poland, 10-14 July 2022, Jul. 2022.

GORBAR, Michal, Stéphane MAUCHLE, Patric AEBI, Beat BITTERLI und Dirk PENNER, 2022. Development of Yb2O3-based ceramics for indirect production of 177Lu used in targeted radionuclide therapies. In: Ceramics in Europe, Kraków, Poland, 10-14 July 2022. Conference presentation. Juli 2022

Gorbar, Michal, Stéphane Mauchle, Patric Aebi, Beat Bitterli, and Dirk Penner. 2022. “Development of Yb2O3-Based Ceramics for Indirect Production of 177Lu Used in Targeted Radionuclide Therapies.” Conference presentation. In Ceramics in Europe, Kraków, Poland, 10-14 July 2022.

Gorbar, Michal, et al. “Development of Yb2O3-Based Ceramics for Indirect Production of 177Lu Used in Targeted Radionuclide Therapies.” Ceramics in Europe, Kraków, Poland, 10-14 July 2022, 2022.