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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26027
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dc.contributor.authorNeuenschwander, Regula-
dc.contributor.authorHebeisen, Monika-
dc.contributor.authorMicheroli, Raphael-
dc.contributor.authorBürki, Kristina-
dc.contributor.authorExer, Pascale-
dc.contributor.authorNiedermann, Karin-
dc.contributor.authorNissen, Michael J.-
dc.contributor.authorScherer, Almut-
dc.contributor.authorCiurea, Adrian-
dc.date.accessioned2022-11-11T10:55:29Z-
dc.date.available2022-11-11T10:55:29Z-
dc.date.issued2020-
dc.identifier.issn1478-6362de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26027-
dc.description.abstractBackground: Sex differences with regard to clinical manifestations and response to tumor necrosis factor inhibitors (TNFi) have been delineated for the radiographic form of axial spondyloarthritis (axSpA). More limited evidence for a differential effectiveness of treatment in genders exists for the nonradiographic disease state (nr-axSpA). The aim of the study was to compare demographics, clinical parameters, and response to TNFi in women versus men with nr-axSpA. Methods: We compared disease characteristics of 264 women and 231 men with nr-axSpA at inclusion in the prospective Swiss Clinical Quality Management Cohort. Response to a first TNFi was assessed in 85 women and 78 men without diagnosed co-morbid fibromyalgia. The primary outcome was the proportion of patients achieving the 40% improvement in the Assessment of SpondyloArthritis international Society criteria (ASAS40) at 1 year. Additional response outcomes were evaluated as secondary outcomes. Patients having discontinued TNFi were considered non-responders. Logistic regression analyses were adjusted for baseline differences, which might potentially mediate the effect of sex on treatment response. Results: Compared to men, women had a longer diagnostic delay, a higher level of perceived disease activity, and more enthesitis and were in a lower percentage HLA-B27 positive. An ASAS40 response was achieved by 17% of women and 38% of men (OR 0.34; 95% CI 0.12, 0.93; p = 0.02). A significantly lower response rate in women was confirmed in the adjusted analysis (OR 0.19; 95% CI 0.05, 0.62; p = 0.009) as well as for the other outcomes assessed. Conclusion: Despite only few sex differences in patient characteristics in nr-axSpA, response rates to TNFi are significantly lower in women than in men.de_CH
dc.language.isoende_CH
dc.publisherBioMed Centralde_CH
dc.relation.ispartofArthritis Research & Therapyde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectAxial spondyloarthritisde_CH
dc.subjectGenderde_CH
dc.subjectNonradiographic axial spondyloarthritisde_CH
dc.subjectTNF inhibitionde_CH
dc.subject.ddc615.82: Physiotherapiede_CH
dc.subject.ddc616.7: Krankheiten des Bewegungsapparates und Orthopädiede_CH
dc.titleDifferences between men and women with nonradiographic axial spondyloarthritis : clinical characteristics and treatment effectiveness in a real-life prospective cohortde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Physiotherapie (IPT)de_CH
dc.identifier.doi10.1186/s13075-020-02337-2de_CH
dc.identifier.doi10.21256/zhaw-26027-
dc.identifier.pmid33036663de_CH
zhaw.funding.euNode_CH
zhaw.issue233de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume22de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Neuenschwander, R., Hebeisen, M., Micheroli, R., Bürki, K., Exer, P., Niedermann, K., Nissen, M. J., Scherer, A., & Ciurea, A. (2020). Differences between men and women with nonradiographic axial spondyloarthritis : clinical characteristics and treatment effectiveness in a real-life prospective cohort. Arthritis Research & Therapy, 22(233). https://doi.org/10.1186/s13075-020-02337-2
Neuenschwander, R. et al. (2020) ‘Differences between men and women with nonradiographic axial spondyloarthritis : clinical characteristics and treatment effectiveness in a real-life prospective cohort’, Arthritis Research & Therapy, 22(233). Available at: https://doi.org/10.1186/s13075-020-02337-2.
R. Neuenschwander et al., “Differences between men and women with nonradiographic axial spondyloarthritis : clinical characteristics and treatment effectiveness in a real-life prospective cohort,” Arthritis Research & Therapy, vol. 22, no. 233, 2020, doi: 10.1186/s13075-020-02337-2.
NEUENSCHWANDER, Regula, Monika HEBEISEN, Raphael MICHEROLI, Kristina BÜRKI, Pascale EXER, Karin NIEDERMANN, Michael J. NISSEN, Almut SCHERER und Adrian CIUREA, 2020. Differences between men and women with nonradiographic axial spondyloarthritis : clinical characteristics and treatment effectiveness in a real-life prospective cohort. Arthritis Research & Therapy. 2020. Bd. 22, Nr. 233. DOI 10.1186/s13075-020-02337-2
Neuenschwander, Regula, Monika Hebeisen, Raphael Micheroli, Kristina Bürki, Pascale Exer, Karin Niedermann, Michael J. Nissen, Almut Scherer, and Adrian Ciurea. 2020. “Differences between Men and Women with Nonradiographic Axial Spondyloarthritis : Clinical Characteristics and Treatment Effectiveness in a Real-Life Prospective Cohort.” Arthritis Research & Therapy 22 (233). https://doi.org/10.1186/s13075-020-02337-2.
Neuenschwander, Regula, et al. “Differences between Men and Women with Nonradiographic Axial Spondyloarthritis : Clinical Characteristics and Treatment Effectiveness in a Real-Life Prospective Cohort.” Arthritis Research & Therapy, vol. 22, no. 233, 2020, https://doi.org/10.1186/s13075-020-02337-2.


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