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https://doi.org/10.21256/zhaw-26892Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Scutigliani, Enzo M. | - |
| dc.contributor.author | Lobo-Cerna, Fernando | - |
| dc.contributor.author | Mingo Barba, Sergio | - |
| dc.contributor.author | Scheidegger, Stephan | - |
| dc.contributor.author | Krawczyk, Przemek M. | - |
| dc.date.accessioned | 2023-02-09T15:12:13Z | - |
| dc.date.available | 2023-02-09T15:12:13Z | - |
| dc.date.issued | 2022-12-24 | - |
| dc.identifier.issn | 2072-6694 | de_CH |
| dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/26892 | - |
| dc.description.abstract | Hyperthermia is clinically applied cancer treatment in conjunction with radio- and/or chemotherapy, in which the tumor volume is exposed to supraphysiological temperatures. Since cells can effectively counteract the effects of hyperthermia by protective measures that are commonly known as the heat stress response, the identification of cellular processes that are essential for surviving hyperthermia could lead to novel treatment strategies that improve its therapeutic effects. Here, we apply a meta-analytic approach to 18 datasets that capture hyperthermia-induced transcriptome alterations in nine different human cancer cell lines. We find, in line with previous reports, that hyperthermia affects multiple processes, including protein folding, cell cycle, mitosis, and cell death, and additionally uncover expression changes of genes involved in KRAS signaling, inflammatory responses, TNF-a signaling and epithelial-to-mesenchymal transition (EMT). Interestingly, however, we also find a considerable inter-study variability, and an apparent absence of a 'universal' heat stress response signature, which is likely caused by the differences in experimental conditions. Our results suggest that gene expression alterations after heat stress are driven, to a large extent, by the experimental context, and call for a more extensive, controlled study that examines the effects of key experimental parameters on global gene expression patterns. | de_CH |
| dc.language.iso | en | de_CH |
| dc.publisher | MDPI | de_CH |
| dc.relation.ispartof | Cancers | de_CH |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | de_CH |
| dc.subject | Gene expression | de_CH |
| dc.subject | Heat shock response | de_CH |
| dc.subject | Hyperthermia | de_CH |
| dc.subject | Meta-analysis | de_CH |
| dc.subject | Neoplasm | de_CH |
| dc.subject | Transcriptome | de_CH |
| dc.subject.ddc | 616: Innere Medizin und Krankheiten | de_CH |
| dc.title | The effects of heat stress on the transcriptome of human cancer cells : a meta-analysis | de_CH |
| dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
| dcterms.type | Text | de_CH |
| zhaw.departement | School of Engineering | de_CH |
| zhaw.organisationalunit | Institut für Angewandte Mathematik und Physik (IAMP) | de_CH |
| dc.identifier.doi | 10.3390/cancers15010113 | de_CH |
| dc.identifier.doi | 10.21256/zhaw-26892 | - |
| dc.identifier.pmid | 36612111 | de_CH |
| zhaw.funding.eu | info:eu-repo/grantAgreement/EC/H2020/955625//Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor/HYPERBOOST | de_CH |
| zhaw.issue | 1 | de_CH |
| zhaw.originated.zhaw | Yes | de_CH |
| zhaw.pages.start | 113 | de_CH |
| zhaw.publication.status | publishedVersion | de_CH |
| zhaw.volume | 15 | de_CH |
| zhaw.publication.review | Peer review (Publikation) | de_CH |
| zhaw.funding.zhaw | Hyperboost | de_CH |
| zhaw.author.additional | No | de_CH |
| zhaw.display.portrait | Yes | de_CH |
| zhaw.relation.references | https://create.figlinq.com/dashboard/e.m.scutigliani:1055/ | de_CH |
| zhaw.relation.references | https://github.com/Krawczyk-Group/Scutigliani-et-al-2022 | de_CH |
| Appears in collections: | Publikationen School of Engineering | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2022_Scutigliani-etal_Heat-stress-effect-on-transcriptome-of-human-cancer-cells.pdf | 5.02 MB | Adobe PDF |  View/Open |
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Scutigliani, E. M., Lobo-Cerna, F., Mingo Barba, S., Scheidegger, S., & Krawczyk, P. M. (2022). The effects of heat stress on the transcriptome of human cancer cells : a meta-analysis. Cancers, 15(1), 113. https://doi.org/10.3390/cancers15010113
Scutigliani, E.M. et al. (2022) ‘The effects of heat stress on the transcriptome of human cancer cells : a meta-analysis’, Cancers, 15(1), p. 113. Available at: https://doi.org/10.3390/cancers15010113.
E. M. Scutigliani, F. Lobo-Cerna, S. Mingo Barba, S. Scheidegger, and P. M. Krawczyk, “The effects of heat stress on the transcriptome of human cancer cells : a meta-analysis,” Cancers, vol. 15, no. 1, p. 113, Dec. 2022, doi: 10.3390/cancers15010113.
SCUTIGLIANI, Enzo M., Fernando LOBO-CERNA, Sergio MINGO BARBA, Stephan SCHEIDEGGER und Przemek M. KRAWCZYK, 2022. The effects of heat stress on the transcriptome of human cancer cells : a meta-analysis. Cancers. 24 Dezember 2022. Bd. 15, Nr. 1, S. 113. DOI 10.3390/cancers15010113
Scutigliani, Enzo M., Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, and Przemek M. Krawczyk. 2022. “The Effects of Heat Stress on the Transcriptome of Human Cancer Cells : A Meta-Analysis.” Cancers 15 (1): 113. https://doi.org/10.3390/cancers15010113.
Scutigliani, Enzo M., et al. “The Effects of Heat Stress on the Transcriptome of Human Cancer Cells : A Meta-Analysis.” Cancers, vol. 15, no. 1, Dec. 2022, p. 113, https://doi.org/10.3390/cancers15010113.
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