Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-4097
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dc.contributor.authorFüchslin, Rudolf Marcel-
dc.contributor.authorFilisetti, Alessandro-
dc.contributor.authorSerra, Roberto-
dc.contributor.authorVillani, Marco-
dc.contributor.authorDeLucrezia, Davide-
dc.contributor.authorPoli, Irene-
dc.date.accessioned2018-02-09T15:00:12Z-
dc.date.available2018-02-09T15:00:12Z-
dc.date.issued2010-
dc.identifier.isbn978-0-262-29075-3de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2722-
dc.descriptionOpen Access Publikationde_CH
dc.description.abstractTheoretical investigations of autocatalytic sets rendered the occurrence of self-sustaining sets of molecules to be a generic property of random reaction networks. This stands in some contrast to the experimental difficulty to actually find such systems. In this work, we argue that the usual approach, which is based on the study of static properties of reaction graphs has to be complemented with a dynamic perspective in order to avoid overestimation of the probability of getting autocatalytic sets. Especially under the, from the experimental point of view, important flow reactor conditions, it is not sufficient just to have a pathway generating a given type of molecules. The respective process has also to happen with a sufficient rate in order to compensate the outflow. Reaction rates are therefore of crucial importance. Furthermore, processes such as cleavage are on one hand advantageous for the system, because they enhance the molecular variability and therefore the potential for catalysis. On the other hand, cleavage may also act in an inhibiting manner by the destruction of vital components: therefore, an optimal balance between ligation and cleavage has to be found. If energy is included as a limiting resource, the concentration profiles of the components of autocatalytic sets are altered in a manner that renders a certain range for the energy supply rate as optimal for the realization of robust autocatalytic sets. The results presented are based on a theoretical model and obtained by numerical integration of systems of ODE. This limits the number of involved molecular species which implies that the quantitative findings of this work may have no direct relevance for experimental situations, whereas the qualitative insights in the dynamics of the systems under consideration may generalize to systems of truly combinatorial size.de_CH
dc.language.isoende_CH
dc.publisherMIT Pressde_CH
dc.relation.ispartofseriesArtificial lifede_CH
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/de_CH
dc.subjectAutocatalytic setsde_CH
dc.subjectAutocatalytic metabolismde_CH
dc.subjectOrigin of lifede_CH
dc.subject.ddc540: Chemiede_CH
dc.subject.ddc570: Biologiede_CH
dc.titleDynamical stability of autocatalytic setsde_CH
dc.typeKonferenz: Paperde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitut für Angewandte Mathematik und Physik (IAMP)de_CH
zhaw.publisher.placeCambridgede_CH
dc.identifier.doi10.21256/zhaw-4097-
zhaw.conference.detailsThe 12th International Conference on the Synthesis and Simulation of Living Systems, Odense, Denmark, 19-23 August 2010de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end72de_CH
zhaw.pages.start65de_CH
zhaw.parentwork.editorFellermann, Harold-
zhaw.parentwork.editorDörr, Marc-
zhaw.parentwork.editorHanczyc, Martin M.-
zhaw.parentwork.editorLadegaard Laursen, Lone-
zhaw.parentwork.editorMaurer, Sarah-
zhaw.parentwork.editorMerkle, Daniel-
zhaw.parentwork.editorMonnard, Pierre Alain-
zhaw.parentwork.editorStøy, Kasper-
zhaw.parentwork.editorRasmussen, Steen-
zhaw.publication.statuspublishedVersionde_CH
zhaw.series.number12de_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
zhaw.title.proceedingsArtificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systemsde_CH
Appears in collections:Publikationen School of Engineering

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Füchslin, R. M., Filisetti, A., Serra, R., Villani, M., DeLucrezia, D., & Poli, I. (2010). Dynamical stability of autocatalytic sets [Conference paper]. In H. Fellermann, M. Dörr, M. M. Hanczyc, L. Ladegaard Laursen, S. Maurer, D. Merkle, P. A. Monnard, K. Støy, & S. Rasmussen (Eds.), Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems (pp. 65–72). MIT Press. https://doi.org/10.21256/zhaw-4097
Füchslin, R.M. et al. (2010) ‘Dynamical stability of autocatalytic sets’, in H. Fellermann et al. (eds) Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems. Cambridge: MIT Press, pp. 65–72. Available at: https://doi.org/10.21256/zhaw-4097.
R. M. Füchslin, A. Filisetti, R. Serra, M. Villani, D. DeLucrezia, and I. Poli, “Dynamical stability of autocatalytic sets,” in Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems, 2010, pp. 65–72. doi: 10.21256/zhaw-4097.
FÜCHSLIN, Rudolf Marcel, Alessandro FILISETTI, Roberto SERRA, Marco VILLANI, Davide DELUCREZIA und Irene POLI, 2010. Dynamical stability of autocatalytic sets. In: Harold FELLERMANN, Marc DÖRR, Martin M. HANCZYC, Lone LADEGAARD LAURSEN, Sarah MAURER, Daniel MERKLE, Pierre Alain MONNARD, Kasper STØY und Steen RASMUSSEN (Hrsg.), Artificial live XII : proceedings of the twelfth international conference on the synthesis and simulation of living systems. Conference paper. Cambridge: MIT Press. 2010. S. 65–72. ISBN 978-0-262-29075-3
Füchslin, Rudolf Marcel, Alessandro Filisetti, Roberto Serra, Marco Villani, Davide DeLucrezia, and Irene Poli. 2010. “Dynamical Stability of Autocatalytic Sets.” Conference paper. In Artificial Live XII : Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems, edited by Harold Fellermann, Marc Dörr, Martin M. Hanczyc, Lone Ladegaard Laursen, Sarah Maurer, Daniel Merkle, Pierre Alain Monnard, Kasper Støy, and Steen Rasmussen, 65–72. Cambridge: MIT Press. https://doi.org/10.21256/zhaw-4097.
Füchslin, Rudolf Marcel, et al. “Dynamical Stability of Autocatalytic Sets.” Artificial Live XII : Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems, edited by Harold Fellermann et al., MIT Press, 2010, pp. 65–72, https://doi.org/10.21256/zhaw-4097.


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