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https://doi.org/10.21256/zhaw-29135| Publication type: | Conference poster |
| Type of review: | Peer review (abstract) |
| Title: | Development of a 3D-printed bio-hybrid skin model for photothermal therapy applications |
| Authors: | Bajrami, Dardan Wei, Kongchang Spano, Fabrizio Bonmarin, Mathias Rossi, René |
| et. al: | No |
| DOI: | 10.21256/zhaw-29135 |
| Conference details: | 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 September 2023 |
| Issue Date: | 4-Sep-2023 |
| Publisher / Ed. Institution: | ZHAW Zürcher Hochschule für Angewandte Wissenschaften |
| Publisher / Ed. Institution: | Winterthur |
| Language: | English |
| Subjects: | Skin; Bio-hybrid; 3D-printing; Skin model |
| Subject (DDC): | 610.28: Biomedicine, biomedical engineering |
| Abstract: | Skin models or phantoms are valuable tools used in biomaterial research to mimic the structure and function of human skin. Optical skin phantoms, in particular, have emerged as promising solutions for studying light interaction with human skin in various biomedical applications, including imaging and laser treatments. How-ever, current optical skin models have limitations in achieving accurate representations of the real skin. These models often fail to consider important factors such as skin color, skin thickness, integration of ap-pendages (e.g., hair follicles, sweat glands, sebaceous glands), and biological response. In this study, we present a novel approach to overcome the limitations of existing artificial skin phantoms by developing a 3D-printed bio-hybrid skin phantom. Our proposed model aims to replicate the optical and thermal proper-ties of human skin and the complex geometry of hair follicles. To achieve this, we combine a skin model mimicking the optical and thermal properties of human skin with the embedding of biological skin cells. The basis of our bio-hybrid skin model is a 3D-printed tissue phantom material that allows for the fabrication of hair follicle like structures. Subsequently, we incorporate biological cells, such as hair follicle cells, into the skin model and engineer induced hair follicle cells to simulate the effects of photothermal therapy on specif-ic cell populations. This enables a comprehensive study of the optical and thermal mechanisms involved in the complex interaction between skin tissue, hair, and the light source. Additionally, we investigate the influ-ence of skin structures, including skin thickness and color, on the outcomes of photothermal therapy. The knowledge gained from our bio-hybrid skin model extends beyond photothermal therapy applications. It can also contribute to the development and testing of other optical treatments, such photodynamic therapy or photobiomodulation. The novel approach provides a platform to study the optical and thermal interactions in biomedical applications. The insights gained from our bio-hybrid skin model have the potential to en-hance future advancements in the field of biomaterials. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/29135 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | School of Engineering |
| Organisational Unit: | Institute of Computational Physics (ICP) |
| Appears in collections: | Publikationen School of Engineering |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2023_Bajrami-etal_3D-printed-bio-hybid-skin-model_ESB23-Poster.pdf | 397.2 kB | Adobe PDF |  View/Open |
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Bajrami, D., Wei, K., Spano, F., Bonmarin, M., & Rossi, R. (2023, September 4). Development of a 3D-printed bio-hybrid skin model for photothermal therapy applications. 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 September 2023. https://doi.org/10.21256/zhaw-29135
Bajrami, D. et al. (2023) ‘Development of a 3D-printed bio-hybrid skin model for photothermal therapy applications’, in 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 September 2023. Winterthur: ZHAW Zürcher Hochschule für Angewandte Wissenschaften. Available at: https://doi.org/10.21256/zhaw-29135.
D. Bajrami, K. Wei, F. Spano, M. Bonmarin, and R. Rossi, “Development of a 3D-printed bio-hybrid skin model for photothermal therapy applications,” in 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 September 2023, Sep. 2023. doi: 10.21256/zhaw-29135.
BAJRAMI, Dardan, Kongchang WEI, Fabrizio SPANO, Mathias BONMARIN und René ROSSI, 2023. Development of a 3D-printed bio-hybrid skin model for photothermal therapy applications. In: 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 September 2023. Conference poster. Winterthur: ZHAW Zürcher Hochschule für Angewandte Wissenschaften. 4 September 2023
Bajrami, Dardan, Kongchang Wei, Fabrizio Spano, Mathias Bonmarin, and René Rossi. 2023. “Development of a 3D-Printed Bio-Hybrid Skin Model for Photothermal Therapy Applications.” Conference poster. In 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 September 2023. Winterthur: ZHAW Zürcher Hochschule für Angewandte Wissenschaften. https://doi.org/10.21256/zhaw-29135.
Bajrami, Dardan, et al. “Development of a 3D-Printed Bio-Hybrid Skin Model for Photothermal Therapy Applications.” 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 September 2023, ZHAW Zürcher Hochschule für Angewandte Wissenschaften, 2023, https://doi.org/10.21256/zhaw-29135.
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