Halogenases for the synthesis of small molecules

Hegarty, Eimear; Büchler, Johannes; Buller, Rebecca M.

doi:10.1016/j.cogsc.2023.100784

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29305

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Halogenases for the synthesis of small molecules
Authors:	Hegarty, Eimear Büchler, Johannes Buller, Rebecca M.
et. al:	No
DOI:	10.1016/j.cogsc.2023.100784 10.21256/zhaw-29305
Published in:	Current Opinion in Green and Sustainable Chemistry
Volume(Issue):	41
Issue:	100784
Issue Date:	Jun-2023
Publisher / Ed. Institution:	Elsevier
ISSN:	2452-2236
Language:	English
Subjects:	Fe(II)/a-ketoglutaratedependenthalogenases; Flavin-dependent halogenase; Late-stage functionalization; Enzyme engineering; C–H activation; Biocatalysis
Subject (DDC):	540: Chemistry
Abstract:	Enzymatic halogenation is a rapidly developing tool in the synthetic chemist's toolbox. Utilizing oxygen, halide salts and operating at ambient temperatures in aqueous media, halogenating enzymes, particularly flavin- or Fe(II)/α-ketoglutarate dependent halogenases, allow the regio- and stereoselective installation of halogen atoms to yield valuable building blocks and uniquely derivatized complex molecules, including natural products. Apart from modulating the physico-chemical properties of molecules and, in consequence, their biological activity, halogen atoms can also serve as chemical linchpins for further derivatization of the molecular scaffold, for example in chemo-enzymatic cascades. Thanks to rapid advances in bioinformatic enzyme sourcing, biosynthetic pathway elucidation and enzyme engineering strategies, the palette of enzymatically produced halogenated structures is constantly growing. In addition, successful studies to improve catalytic performance of the halogenation biocatalysts are boding well for industrial applications.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29305
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Hegarty, E., Büchler, J., & Buller, R. M. (2023). Halogenases for the synthesis of small molecules. Current Opinion in Green and Sustainable Chemistry, 41(100784). https://doi.org/10.1016/j.cogsc.2023.100784

Hegarty, E., Büchler, J. and Buller, R.M. (2023) ‘Halogenases for the synthesis of small molecules’, Current Opinion in Green and Sustainable Chemistry, 41(100784). Available at: https://doi.org/10.1016/j.cogsc.2023.100784.

E. Hegarty, J. Büchler, and R. M. Buller, “Halogenases for the synthesis of small molecules,” Current Opinion in Green and Sustainable Chemistry, vol. 41, no. 100784, Jun. 2023, doi: 10.1016/j.cogsc.2023.100784.

HEGARTY, Eimear, Johannes BÜCHLER und Rebecca M. BULLER, 2023. Halogenases for the synthesis of small molecules. Current Opinion in Green and Sustainable Chemistry. Juni 2023. Bd. 41, Nr. 100784. DOI 10.1016/j.cogsc.2023.100784

Hegarty, Eimear, Johannes Büchler, and Rebecca M. Buller. 2023. “Halogenases for the Synthesis of Small Molecules.” Current Opinion in Green and Sustainable Chemistry 41 (100784). https://doi.org/10.1016/j.cogsc.2023.100784.

Hegarty, Eimear, et al. “Halogenases for the Synthesis of Small Molecules.” Current Opinion in Green and Sustainable Chemistry, vol. 41, no. 100784, June 2023, https://doi.org/10.1016/j.cogsc.2023.100784.