Immunomodulatory studies on selected plants from the Hallwyl "Kräuterbuch" : an influential recipe text from 16th century Switzerland

Stehlin, Jonas; Peter, Samuel; Albert, Ina; Vahekeni, Nina; Wolfram, Evelyn; Frei-Haller, Barbara; Lardos, Andreas

Publication type:	Conference poster
Type of review:	Peer review (abstract)
Title:	Immunomodulatory studies on selected plants from the Hallwyl "Kräuterbuch" : an influential recipe text from 16th century Switzerland
Authors:	Stehlin, Jonas Peter, Samuel Albert, Ina Vahekeni, Nina Wolfram, Evelyn Frei-Haller, Barbara Lardos, Andreas
et. al:	No
Published in:	Planta Medica
Volume(Issue):	89
Issue:	14
Page(s):	1392
Pages to:	1393
Conference details:	71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Dublin, Ireland, 2–5 July 2023
Issue Date:	2023
Publisher / Ed. Institution:	Thieme
ISSN:	0032-0943 1439-0221
Language:	English
Subjects:	Pflanze; Arzneimittel; Schweiz; 16. Jahrhundert
Subject (DDC):	580: Plants (Botany) 615: Pharmacology and therapeutics
Abstract:	An ex vivo screening effort using plants from the “Arzneibuch von Hallwyl” (ABvH), an influential recipe text from 16th-century Switzerland, was carried out with the goal of exploring the immunomodulatory potential of medicinal plants that have largely fallen out of use in modern practice. An ex vivo screening model using a human whole blood assay (WBA) stimulated with LPS was chosen to measure perturbation of IL-6 release in 21 preparations, 5 of which were directly based on recipes from the ABvH. Candidates with promising activity were then to be tested in LPS-activated human PBMC for comparison with the results of the WBA. MTT assay was chosen to characterise the cytotoxic profile of active extracts. Eight of the 21 tested samples showed heterogenous effects on IL-6 release in the WBA. In the PBMC assay the 80% EtOH extract from the roots of Vincetoxicum hirundinaria Medik. (VHR) showed the strongest ex vivo inhibition with an IC50 of 3.62±0.47 μg/mL. Results of the MTT assay in NIH-3T3 fibroblasts suggest a minor cytotoxic potential of most samples. The data gathered during this study points to promising ex vivo immunomodulatory activity exhibited by the active samples and rationalises further screening efforts based on plants from the ABvH.
URI:	https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171 https://digitalcollection.zhaw.ch/handle/11475/29912
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Stehlin, J., Peter, S., Albert, I., Vahekeni, N., Wolfram, E., Frei-Haller, B., & Lardos, A. (2023). Immunomodulatory studies on selected plants from the Hallwyl “Kräuterbuch” : an influential recipe text from 16th century Switzerland [Conference poster]. Planta Medica, 89(14), 1392–1393. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171

Stehlin, J. et al. (2023) ‘Immunomodulatory studies on selected plants from the Hallwyl ‘Kräuterbuch’ : an influential recipe text from 16th century Switzerland’, in Planta Medica. Thieme, pp. 1392–1393. Available at: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171.

J. Stehlin et al., “Immunomodulatory studies on selected plants from the Hallwyl “Kräuterbuch” : an influential recipe text from 16th century Switzerland,” in Planta Medica, 2023, vol. 89, no. 14, pp. 1392–1393. [Online]. Available: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171

STEHLIN, Jonas, Samuel PETER, Ina ALBERT, Nina VAHEKENI, Evelyn WOLFRAM, Barbara FREI-HALLER und Andreas LARDOS, 2023. Immunomodulatory studies on selected plants from the Hallwyl „Kräuterbuch“ : an influential recipe text from 16th century Switzerland. In: Planta Medica [online]. Conference poster. Thieme. 2023. S. 1392–1393. Verfügbar unter: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171

Stehlin, Jonas, Samuel Peter, Ina Albert, Nina Vahekeni, Evelyn Wolfram, Barbara Frei-Haller, and Andreas Lardos. 2023. “Immunomodulatory Studies on Selected Plants from the Hallwyl “Kräuterbuch” : An Influential Recipe Text from 16th Century Switzerland.” Conference poster. In Planta Medica, 89:1392–93. Thieme. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171.

Stehlin, Jonas, et al. “Immunomodulatory Studies on Selected Plants from the Hallwyl “Kräuterbuch” : An Influential Recipe Text from 16th Century Switzerland.” Planta Medica, vol. 89, no. 14, Thieme, 2023, pp. 1392–93, https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774171.